INT89054

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Context Info
Confidence 0.70
First Reported 2000
Last Reported 2010
Negated 8
Speculated 4
Reported most in Abstract
Documents 156
Total Number 163
Disease Relevance 90.78
Pain Relevance 102.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) plasma membrane (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
neurons 72
DRG 14
nociceptors 12
embryonic kidney 8
spinal cord 8
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 1942 100.00 Very High Very High Very High
dorsal root ganglion 1499 100.00 Very High Very High Very High
Inflammation 710 100.00 Very High Very High Very High
Thermal hyperalgesia 703 100.00 Very High Very High Very High
antagonist 623 100.00 Very High Very High Very High
Calcitonin gene-related peptide 583 100.00 Very High Very High Very High
agonist 562 100.00 Very High Very High Very High
trigeminal ganglion 221 100.00 Very High Very High Very High
substance P 203 100.00 Very High Very High Very High
Action potential 202 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1779 100.00 Very High Very High Very High
Hyperalgesia 937 100.00 Very High Very High Very High
INFLAMMATION 677 100.00 Very High Very High Very High
Nervous System Injury 112 99.98 Very High Very High Very High
Inflammatory Pain 369 99.96 Very High Very High Very High
Anxiety Disorder 193 99.96 Very High Very High Very High
Neuropathic Pain 921 99.92 Very High Very High Very High
Cancer Pain 115 99.92 Very High Very High Very High
Bone Cancer 383 99.82 Very High Very High Very High
Temporomandibular Joint Syndrome 21 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Real-time PCR and immunoblotting demonstrated that TMJ inflammation significantly induced hippocampal TRPV1 expression compared with the control group but failed to induce it in the ovariectomized rats that received no estradiol replacement.
Neg (failed) Positive_regulation (induced) of Gene_expression (expression) of TRPV1 in TMJ associated with snapping jaw and inflammation
1) Confidence 0.70 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20592193 Disease Relevance 1.40 Pain Relevance 1.44
In addition, estradiol potentiated TMJ inflammation-induced hippocampal TRPV1 expression in a dose-dependent manner in the ovariectomized rats.
Positive_regulation (induced) of Gene_expression (expression) of TRPV1 in TMJ associated with snapping jaw and inflammation
2) Confidence 0.70 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20592193 Disease Relevance 1.50 Pain Relevance 1.59
Our results suggested that hippocampal TRPV1 can modulate central pain processing and estradiol may contribute to the sexual dimorphism of TMD pain sensitivity through upregulation of TRPV1 expression in the hippocampus.
Positive_regulation (upregulation) of Gene_expression (expression) of TRPV1 in hippocampus associated with pain, central pain and hippocampus
3) Confidence 0.70 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20592193 Disease Relevance 1.17 Pain Relevance 1.32
Colocalization studies demonstrated that VR1 expression was increased in large myelinated A-fiber DRG neurons, whereas it was decreased in small unmyelinated C-fiber neurons as a result of diabetes.
Positive_regulation (increased) of Gene_expression (expression) of VR1 in neurons associated with c fibre, dorsal root ganglion, diabetes mellitus and unmyelinated
4) Confidence 0.70 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15513920 Disease Relevance 1.50 Pain Relevance 1.06
TRPV1 expression was increased in dorsal root ganglia-containing colon afferent neurons.
Positive_regulation (increased) of Gene_expression (expression) of TRPV1 in dorsal root ganglia
5) Confidence 0.70 Published 2007 Journal Gastroenterology Section Body Doc Link 17258716 Disease Relevance 0.07 Pain Relevance 0
Within 2 weeks of inflammation, the expression of TRPV1 in small and medium-sized TG neurons increased obviously.
Positive_regulation (increased) of Gene_expression (expression) of TRPV1 in neurons
6) Confidence 0.70 Published 2007 Journal Neuroscience bulletin Section Body Doc Link 17592531 Disease Relevance 0.05 Pain Relevance 0
Local inflammation increases vanilloid receptor 1 expression within distinct subgroups of DRG neurons.
Positive_regulation (increases) of Gene_expression (expression) of vanilloid receptor 1 in neurons associated with inflammation
7) Confidence 0.70 Published 2003 Journal Brain Res. Section Title Doc Link 12560124 Disease Relevance 0.76 Pain Relevance 0.61
Area frequency histograms showed that VR1 expression increased in small and medium-sized neurons after inflammation.
Positive_regulation (increased) of Gene_expression (expression) of VR1 in neurons associated with inflammation
8) Confidence 0.70 Published 2003 Journal Brain Res. Section Abstract Doc Link 12560124 Disease Relevance 0.76 Pain Relevance 0.52
VR1 expression correspondingly increased from day 1 to day 21 with peak at day 14, and returning to the control level at day 28.
Positive_regulation (increased) of Gene_expression (expression) of VR1
9) Confidence 0.70 Published 2004 Journal Neuroreport Section Abstract Doc Link 15094470 Disease Relevance 0.58 Pain Relevance 0.43
High sodium upregulates mesenteric TRPV1 expression, and increases NADA-induced CGRP release in vitro and in vivo.


Positive_regulation (upregulates) of Gene_expression (expression) of TRPV1
10) Confidence 0.70 Published 2007 Journal J. Hypertens. Section Body Doc Link 17984664 Disease Relevance 0 Pain Relevance 0
By means of real-time PCR and western blot analysis, TRPV1 expression was significantly upregulated in spiral ganglion cells 2 h after salicylate injection and this upregulation together with the increase in the number of false positive responses was significantly suppressed by capsazepine (10 mg/kg i.p.), a specific antagonist of TRPV1.
Positive_regulation (upregulated) of Gene_expression (expression) of TRPV1 in spiral ganglion associated with ganglion cysts and antagonist
11) Confidence 0.69 Published 2010 Journal Neuroscience Section Abstract Doc Link 19958810 Disease Relevance 0.58 Pain Relevance 0.14
TRPV1 expression levels in the ipsilateral cervical DRG were also elevated after forepaw inflammation.
Positive_regulation (elevated) of Gene_expression (expression) of TRPV1 in DRG associated with inflammation
12) Confidence 0.69 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17509082 Disease Relevance 1.43 Pain Relevance 0.82
Analysis of the backlabelled population in the osteoarthritis model and controls showed an increase in both CGRP and TRPV1 expression in the iodoacetate model compared with control animals.
Positive_regulation (increase) of Gene_expression (expression) of TRPV1 associated with osteoarthritis and calcitonin gene-related peptide
13) Confidence 0.69 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 16039054 Disease Relevance 0.65 Pain Relevance 0.86
Interestingly, the expression of TRPV1 was increased in the uninjured ipsilateral maxillary TG neurons as well as in the uninjured ipsilateral mandibular TG neurons.
Positive_regulation (increased) of Gene_expression (expression) of TRPV1 in neurons associated with trigeminal ganglion
14) Confidence 0.69 Published 2008 Journal J Pain Section Abstract Doc Link 18226965 Disease Relevance 1.68 Pain Relevance 0.83
This article presents that TRPV1 expression was increased in uninjured neurons rather than injured neurons after peripheral nerve injury.
Positive_regulation (increased) of Gene_expression (expression) of TRPV1 in neurons associated with nervous system injury and peripheral nerve injury
15) Confidence 0.69 Published 2008 Journal J Pain Section Abstract Doc Link 18226965 Disease Relevance 1.47 Pain Relevance 0.92
Increased VR1 expression in vascular and renal tissues may serve as a compensatory response to HS intake, which contributes to maintenance of normal salt sensitivity.


Positive_regulation (Increased) of Gene_expression (expression) of VR1
16) Confidence 0.69 Published 2003 Journal J. Hypertens. Section Body Doc Link 12872047 Disease Relevance 0 Pain Relevance 0
VR1 protein expression, which co-localized with CGRP, was increased in mesenteric resistance arteries and the renal medulla.
Positive_regulation (increased) of Gene_expression (expression) of VR1 protein in renal medulla
17) Confidence 0.69 Published 2003 Journal J. Hypertens. Section Body Doc Link 12872047 Disease Relevance 0 Pain Relevance 0
We found that TRPV1 expression increased in distinct small DRG neurons.
Positive_regulation (increased) of Gene_expression (expression) of TRPV1 in neurons associated with dorsal root ganglion
18) Confidence 0.69 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628345 Disease Relevance 1.13 Pain Relevance 0.72
In the present study, with Western blotting, a quantification method, we confirmed our previous report with immunohistochemical staining that TRPV1 protein expression in DRG was significantly increased relative to control beginning day 1 and throughout the 28 after CFA injection (Figs. 2, 3 and 4).
Positive_regulation (increased) of Gene_expression (expression) of TRPV1 protein associated with dorsal root ganglion
19) Confidence 0.69 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628345 Disease Relevance 1.44 Pain Relevance 1.28
Shifting and role of the increased TRPV1 expression in different subtypes of DRG neurons during chronic inflammatory nociception after CFA injection
Positive_regulation (increased) of Gene_expression (expression) of TRPV1 in neurons associated with nociception, dorsal root ganglion and inflammation
20) Confidence 0.69 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628345 Disease Relevance 1.61 Pain Relevance 1.29

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