INT89055

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Context Info
Confidence 0.61
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 60
Total Number 60
Disease Relevance 13.41
Pain Relevance 32.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkaca) nucleoplasm (Prkaca) mitochondrion (Prkaca)
Golgi apparatus (Prkaca) plasma membrane (Prkaca) nucleus (Prkaca)
Anatomy Link Frequency
neurons 6
cardiomyocytes 4
visceral 1
spinal nerve 1
brainstem 1
Prkaca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 408 100.00 Very High Very High Very High
Spinal cord 265 100.00 Very High Very High Very High
qutenza 197 100.00 Very High Very High Very High
Kinase C 122 100.00 Very High Very High Very High
Dorsal horn neuron 80 100.00 Very High Very High Very High
spinothalamic tract 51 100.00 Very High Very High Very High
Pain 584 99.82 Very High Very High Very High
pregabalin 200 99.66 Very High Very High Very High
Peripheral nerve injury 1 99.44 Very High Very High Very High
Opioid 62 99.34 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 585 99.82 Very High Very High Very High
Nervous System Injury 19 99.44 Very High Very High Very High
Aging 20 99.08 Very High Very High Very High
Arthritis 333 99.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

81 98.80 Very High Very High Very High
Ganglion Cysts 177 97.84 Very High Very High Very High
Neuropathic Pain 108 97.68 Very High Very High Very High
Nociception 302 96.44 Very High Very High Very High
Urological Neuroanatomy 8 96.00 Very High Very High Very High
Bone Cancer 43 95.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The forskolin-induced current potentiation was greatly reduced in cells transfected with VR-1 mutants carrying point mutations at the predicted PKA phosphorylation sites.
Phosphorylation (phosphorylation) of PKA
1) Confidence 0.61 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12040081 Disease Relevance 0.30 Pain Relevance 0.43
The heat transducer VR-1 is therefore suggested as the molecular target of PKA phosphorylation, and potentiation of current responses to heat depends on phosphorylation at predicted PKA consensus sites.
Phosphorylation (phosphorylation) of PKA
2) Confidence 0.61 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12040081 Disease Relevance 0.14 Pain Relevance 0.21
The heat transducer VR-1 is therefore suggested as the molecular target of PKA phosphorylation, and potentiation of current responses to heat depends on phosphorylation at predicted PKA consensus sites.
Phosphorylation (phosphorylation) of PKA
3) Confidence 0.61 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12040081 Disease Relevance 0.24 Pain Relevance 0.28
The NMDA receptor 1 subunit (NR1) is phosphorylated by protein kinase A (PKA) on serine 890 and 897.
Phosphorylation (phosphorylated) of PKA associated with nmda receptor
4) Confidence 0.57 Published 2002 Journal Neuroscience Section Abstract Doc Link 12435416 Disease Relevance 0 Pain Relevance 0.65
The potentiation was prevented in the presence of the selective PKA inhibitor PKI(14-22), suggesting PKA-mediated phosphorylation of the heat transducer protein.
Phosphorylation (phosphorylation) of PKA-mediated
5) Confidence 0.47 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12040081 Disease Relevance 0.57 Pain Relevance 0.55
In order to assess whether these modifications were related to modified cyclic AMP-dependent protein kinase (PKA) activity, the phosphorylation levels of two other PKA substrates were examined, the GluR1 and NR1 subunits of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate and NMDA receptors respectively.
Phosphorylation (phosphorylation) of cyclic AMP-dependent protein kinase associated with nmda receptor
6) Confidence 0.44 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15287884 Disease Relevance 0 Pain Relevance 1.20
In order to assess whether these modifications were related to modified cyclic AMP-dependent protein kinase (PKA) activity, the phosphorylation levels of two other PKA substrates were examined, the GluR1 and NR1 subunits of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate and NMDA receptors respectively.
Phosphorylation (phosphorylation) of PKA associated with nmda receptor
7) Confidence 0.44 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15287884 Disease Relevance 0 Pain Relevance 1.18
In order to assess whether these modifications were related to modified cyclic AMP-dependent protein kinase (PKA) activity, the phosphorylation levels of two other PKA substrates were examined, the GluR1 and NR1 subunits of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate and NMDA receptors respectively.
Phosphorylation (phosphorylation) of PKA associated with nmda receptor
8) Confidence 0.44 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15287884 Disease Relevance 0 Pain Relevance 1.18
However, the phosphorylation of deep STT cells involves both PKA and PKC.
Phosphorylation (phosphorylation) of PKA associated with spinothalamic tract
9) Confidence 0.44 Published 2002 Journal Neuroscience Section Abstract Doc Link 12435416 Disease Relevance 0 Pain Relevance 0.95
Combined with our previous findings, the present results indicate that NR1 in spinal dorsal horn neurons, including the superficial dorsal horn STT cells, is phosphorylated following CAP injection and that this phosphorylation is due to the action of PKA.
Phosphorylation (phosphorylation) of PKA in neurons associated with spinothalamic tract, qutenza, dorsal horn and dorsal horn neuron
10) Confidence 0.44 Published 2002 Journal Neuroscience Section Abstract Doc Link 12435416 Disease Relevance 0 Pain Relevance 0.97
NMDA receptor phosphorylation by PKA or PKC also accelerates the rise and decay times of the ion channel [69,78], which explains the absence of apparent differences in the kinetics of NMDA EPSC and compound EPSC in the present study.
Phosphorylation (phosphorylation) of PKA associated with nmda receptor
11) Confidence 0.44 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.32 Pain Relevance 0.59
PKA, PKC, and ERK can phosphorylate NMDA receptors to enhance current flow through the receptor and accelerate the kinetics of the ion channel [41-43,69-71].
Phosphorylation (phosphorylate) of PKA associated with nmda receptor
12) Confidence 0.43 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.39 Pain Relevance 1.19
In contrast with isoproterenol, ethanol exposure did not increase cAMP accumulation, PKA activity, or the phosphorylated form of CREB.
Phosphorylation (phosphorylated) of PKA
13) Confidence 0.34 Published 2000 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 10923996 Disease Relevance 0 Pain Relevance 0
Blocking phosphorylation with PKA and ERK inhibitors would shift the balance from phosphorylation toward dephosphorylation by constitutively active phosphatases [71].
Phosphorylation (phosphorylation) of PKA
14) Confidence 0.33 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.41 Pain Relevance 0.96
Kinetics of phosphorylation by PKA and ERK are fast (1–5 min) [41,41,43].
Phosphorylation (phosphorylation) of PKA
15) Confidence 0.33 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.44 Pain Relevance 1.03
Attenuated expression of withdrawal behaviors correlated with decreased c-Fos expression and intracellular signal transduction elements [protein kinase A regulatory subunit II (PKA) and phosphorylated cAMP response element binding protein (pCREB)] in brainstem noradrenergic nuclei.
Phosphorylation (phosphorylated) of PKA in brainstem associated with medulla and withdrawal
16) Confidence 0.31 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16385558 Disease Relevance 0.08 Pain Relevance 0.56
Finally, the same nuclei were examined for protein kinase A regulatory subunit II (PKA) and phosphorylated cyclic adenosine monophosphate response element binding protein (pCREB), using Western blot analysis.
Phosphorylation (phosphorylated) of PKA
17) Confidence 0.30 Published 2004 Journal Biol. Psychiatry Section Body Doc Link 15312814 Disease Relevance 0 Pain Relevance 0
We employed inhibitors and activators of protein kinase A (PKA), protein kinase C (PKC), extracellular signal-regulated kinase 1 and 2 (ERK1/2) and calcium/calmodulin-dependent kinase II (CaMKII) to examine whether these kinases individually or in concert mediate the increase in CREB phosphorylation that is evident as early as 2 h after loose ligation of the sciatic nerve.
Phosphorylation (inhibitors) of PKA in sciatic nerve associated with kinase c and sciatic nerve
18) Confidence 0.30 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15882794 Disease Relevance 0.20 Pain Relevance 0.38
Significantly, forskolin-stimulated CGRP release could be closely correlated with the phosphorylation of the protein kinase A (PKA) substrate cyclic AMP response element-binding protein (CREB).
Phosphorylation (phosphorylation) of PKA associated with calcitonin gene-related peptide
19) Confidence 0.29 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11353815 Disease Relevance 0.08 Pain Relevance 0.55
Arthritis pain-related synaptic plasticity and central sensitization in the CeLC require the upregulation of presynaptic metabotropic glutamate receptors [12,16] and increased postsynaptic NMDA receptor function through a mechanism that involves NR1 phosphorylation by PKA [13,17].
Phosphorylation (phosphorylation) of PKA associated with pain, central sensitization, nmda receptor, glutamate receptor, amygdala and arthritis
20) Confidence 0.29 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 1.30 Pain Relevance 1.65

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