INT89056

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Context Info
Confidence 0.82
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 46
Total Number 46
Disease Relevance 13.52
Pain Relevance 22.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) plasma membrane (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
neurons 6
dorsal root ganglia 3
sensory neurons 2
primary sensory neurons 2
dorsal horns 1
Trpv1 (Rattus norvegicus)
Trpv1 - S800A (3) Trpv1 - S116A (1)
Pain Link Frequency Relevance Heat
qutenza 560 100.00 Very High Very High Very High
Kinase C 98 99.98 Very High Very High Very High
Eae 27 99.96 Very High Very High Very High
Calcitonin gene-related peptide 9 99.56 Very High Very High Very High
Cannabinoid 60 99.52 Very High Very High Very High
trigeminal ganglion 7 99.48 Very High Very High Very High
agonist 110 99.32 Very High Very High Very High
dorsal root ganglion 179 99.08 Very High Very High Very High
Thermal hyperalgesia 45 98.44 Very High Very High Very High
Nerve growth factor 41 98.30 Very High Very High Very High
Disease Link Frequency Relevance Heat
Inflammatory Pain 35 99.96 Very High Very High Very High
Ganglion Cysts 206 99.48 Very High Very High Very High
Diabetes Mellitus 11 99.32 Very High Very High Very High
Nociception 94 98.60 Very High Very High Very High
Hyperalgesia 115 98.44 Very High Very High Very High
INFLAMMATION 91 97.64 Very High Very High Very High
Pain 216 96.86 Very High Very High Very High
Herpes Simplex Virus 3 96.74 Very High Very High Very High
Neuropathic Pain 180 93.52 High High
Hypoxia 2 93.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased phosphorylation levels of VR1 were also observed in DRG neurons from diabetic rats.
Phosphorylation (phosphorylation) of VR1 in neurons associated with dorsal root ganglion and diabetes mellitus
1) Confidence 0.82 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15513920 Disease Relevance 1.75 Pain Relevance 1.27
Furthermore, protein kinase C-dependent phosphorylation of Ser800 in the TRPV1 C terminus potentiated agonist-evoked ionic selectivity changes.
Phosphorylation (phosphorylation) of TRPV1 associated with kinase c and agonist
2) Confidence 0.82 Published 2008 Journal Nat. Neurosci. Section Abstract Doc Link 18391945 Disease Relevance 0 Pain Relevance 0.42
Phosphorylation of the vanilloid receptor (TRPV1) by protein kinase C epsilon (PKCepsilon) plays an important role in the development of chronic pain.
Phosphorylation (Phosphorylation) of vanilloid receptor associated with kinase c and lasting pain
3) Confidence 0.82 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18973552 Disease Relevance 0.26 Pain Relevance 0.52
Phosphorylation of the vanilloid receptor (TRPV1) by protein kinase C epsilon (PKCepsilon) plays an important role in the development of chronic pain.
Phosphorylation (Phosphorylation) of TRPV1 associated with kinase c and lasting pain
4) Confidence 0.82 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18973552 Disease Relevance 0.31 Pain Relevance 0.58
In contrast, treatment of control DRGs in vitro with the CB1 receptor agonist WIN 55,212-2 decreased the levels of TRPV1 and TRPV1 phosphorylation.
Phosphorylation (phosphorylation) of TRPV1
5) Confidence 0.82 Published 2009 Journal Gut Section Body Doc Link 18936104 Disease Relevance 0.10 Pain Relevance 0
In contrast, treatment of control DRGs in vitro with the CB1 receptor agonist WIN 55,212-2 decreased the levels of TRPV1 and TRPV1 phosphorylation.
Phosphorylation (phosphorylation) of TRPV1
6) Confidence 0.82 Published 2009 Journal Gut Section Body Doc Link 18936104 Disease Relevance 0.05 Pain Relevance 0
NGF also activates phosphoinositide 3-kinase (PI3K)-SRC kinase signalling pathway which phosphorylates intracellular stores of TRPV1 leading to its assembly within the cellular membrane [67].


Phosphorylation (phosphorylates) of TRPV1 associated with nerve growth factor
7) Confidence 0.82 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959024 Disease Relevance 0.71 Pain Relevance 0.89
At this concentration, chelerythrine effectively blocked the tachyphylaxis of TRPV1 upon repetitive stimulation [see Additional file 1], which is known to be caused by PKC phosphorylation of TRPV1 [27].
Phosphorylation (phosphorylation) of TRPV1 associated with kinase c
8) Confidence 0.81 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576176 Disease Relevance 0.08 Pain Relevance 0.26
The phosphorylation of VR1 by several kinases has been reported, mostly by indirect evidence.
Phosphorylation (phosphorylation) of VR1
9) Confidence 0.81 Published 2005 Journal Arch. Pharm. Res. Section Abstract Doc Link 15918513 Disease Relevance 0 Pain Relevance 0.17
PGE2 increases cAMP levels and therefore activates PKA, which directly phosphorylates the channel [62] within Thr 144, Thr 370, and Ser 502 residues which have been implicated in sensitization of heat-evoked TRPV1 receptor responses, suggesting a role for PKA in the development of thermal hyperalgesia [63].
Phosphorylation (phosphorylates) of TRPV1 receptor in PGE2 associated with thermal hyperalgesia
10) Confidence 0.81 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959024 Disease Relevance 0.34 Pain Relevance 0.57
The potentiation seems to be caused by phosphorylation of the serine residues of TRPV1 by PKC.
Phosphorylation (phosphorylation) of TRPV1
11) Confidence 0.80 Published 2010 Journal Yakugaku Zasshi Section Abstract Doc Link 20190512 Disease Relevance 1.18 Pain Relevance 0.57
Biochemical analysis demonstrated that PRL increased (>50%) phosphorylation levels of TRPV1 in TG.
Phosphorylation (phosphorylation) of TRPV1
12) Confidence 0.79 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16885226 Disease Relevance 0.11 Pain Relevance 0.57
to the cell membrane triggers TRPV1 phosphorylation and sensitization [24].
Phosphorylation (phosphorylation) of TRPV1
13) Confidence 0.79 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004845 Disease Relevance 0.42 Pain Relevance 0.65
Because phosphorylation of TRPV1 (transient receptor potential subtype V1) plays a key role in the induction of thermal hyperalgesia in inflammatory pain models, we evaluated whether the cannabinoid agonist WIN 55,212-2 (WIN) regulates the phosphorylation state of TRPV1.
Phosphorylation (phosphorylation) of TRPV1 associated with cannabinoid, ipn, thermal hyperalgesia and agonist
14) Confidence 0.78 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16954222 Disease Relevance 0.46 Pain Relevance 0.51
Here, we show that treatment of primary rat trigeminal ganglion cultures with WIN led to dephosphorylation of TRPV1, specifically at threonine residues.
Phosphorylation (dephosphorylation) of TRPV1 in trigeminal ganglion associated with ganglion cysts and trigeminal ganglion
15) Confidence 0.78 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16954222 Disease Relevance 0.44 Pain Relevance 0.48
Cannabinoid WIN 55,212-2 regulates TRPV1 phosphorylation in sensory neurons.
Phosphorylation (phosphorylation) of TRPV1 in sensory neurons associated with cannabinoid
16) Confidence 0.78 Published 2006 Journal J. Biol. Chem. Section Title Doc Link 16954222 Disease Relevance 0.44 Pain Relevance 0.53
Because phosphorylation of TRPV1 (transient receptor potential subtype V1) plays a key role in the induction of thermal hyperalgesia in inflammatory pain models, we evaluated whether the cannabinoid agonist WIN 55,212-2 (WIN) regulates the phosphorylation state of TRPV1.
Phosphorylation (phosphorylation) of TRPV1 associated with cannabinoid, ipn, thermal hyperalgesia and agonist
17) Confidence 0.78 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16954222 Disease Relevance 0.46 Pain Relevance 0.50
We also confirm the importance of TRPA1 in WIN-induced dephosphorylation of TRPV1 in Chinese hamster ovary cells through targeted expression of one or both receptor channels.
Phosphorylation (dephosphorylation) of TRPV1 in ovary
18) Confidence 0.78 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16954222 Disease Relevance 0.31 Pain Relevance 0.50
Furthermore, knockdown of TRPA1 (transient receptor potential subtype A1) expression in sensory neurons by specific small interfering RNA abolished the WIN effect on TRPV1 dephosphorylation, suggesting that WIN acts through TRPA1.
Phosphorylation (dephosphorylation) of TRPV1 in sensory neurons
19) Confidence 0.77 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16954222 Disease Relevance 0.33 Pain Relevance 0.51
These data suggest that activation of NK2 receptors in afferent neurons leads to PKC-induced phosphorylation of TRPV1, resulting in sensitization of CAPS-evoked currents and slower desensitization.
Phosphorylation (phosphorylation) of TRPV1 in afferent neurons
20) Confidence 0.75 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18598261 Disease Relevance 0 Pain Relevance 0.36

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