INT89058

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Context Info
Confidence 0.04
First Reported 2000
Last Reported 2000
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.35
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkaca, Trpv1) plasma membrane (Prkaca, Trpv1) nucleoplasm (Prkaca)
mitochondrion (Prkaca) Golgi apparatus (Prkaca) protein complex (Prkaca)
Anatomy Link Frequency
neurons 2
Prkaca (Rattus norvegicus)
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 3 93.20 High High
qutenza 5 83.92 Quite High
Pain 1 69.24 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 3 92.72 High High
Pain 1 69.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results raise two possibilities. (1) Direct phosphorylation of VR1 by PKA may not be responsible for the sensitization; instead, phosphorylation of regulatory proteins associated with VR1 would account for the sensitization of I(CAP) evoked by prostaglandin E(2) in dorsal root ganglion (DRG) neurons. (2) DRG neurons may have a different PKA signaling mechanism that is not replicable in Xenopus oocytes or Aplysia R2 neurons.
PKA Neg (not) Regulation (responsible) of Phosphorylation (phosphorylation) of VR1 in neurons associated with ganglion cysts and dorsal root ganglion
1) Confidence 0.04 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10869815 Disease Relevance 0.35 Pain Relevance 0.51

General Comments

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