INT89084

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.51
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 15
Total Number 17
Disease Relevance 4.92
Pain Relevance 6.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slco1c1)
Anatomy Link Frequency
brain 6
blood 3
Slco1c1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
IPN 16 99.90 Very High Very High Very High
Morphine 33 99.64 Very High Very High Very High
bradykinin 4 99.60 Very High Very High Very High
antagonist 25 99.28 Very High Very High Very High
Opioid 5 99.16 Very High Very High Very High
agonist 5 99.16 Very High Very High Very High
Analgesic 4 98.88 Very High Very High Very High
Pain 9 98.44 Very High Very High Very High
withdrawal 7 97.60 Very High Very High Very High
Spinal cord 59 95.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Gliosis 16 100.00 Very High Very High Very High
Pressure And Volume Under Development 6 99.92 Very High Very High Very High
Inflammatory Pain 16 99.90 Very High Very High Very High
Brain Disease 4 98.88 Very High Very High Very High
Stress 6 98.60 Very High Very High Very High
Pain 17 98.44 Very High Very High Very High
INFLAMMATION 40 95.08 Very High Very High Very High
Injury 89 94.60 High High
Nervous System Injury 118 89.68 High High
Camurati-engelmann Disease 3 87.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The BBB equilibration of morphine, expressed as the ratio of areas under the curve between striatum and venous blood, was less than unity (0.28+/-0.09 and 0.22+/-0.17 for 10 and 40 mg/kg), respectively, indicating active efflux of morphine across the BBB.
Gene_expression (expressed) of BBB in blood
1) Confidence 0.51 Published 2000 Journal Pharm. Res. Section Body Doc Link 11145227 Disease Relevance 0 Pain Relevance 0
Pretreatment with an antioxidant H-290/51 markedly attenuated the BBB dysfunction, brain edema formation and brain pathology during morphine withdrawal phases.
Gene_expression (dysfunction) of BBB in brain associated with pressure and volume under development, brain disease, withdrawal and morphine
2) Confidence 0.32 Published 2010 Journal Acta Neurochir. Suppl. Section Abstract Doc Link 19812922 Disease Relevance 0.82 Pain Relevance 0.82
We have determined the effect of chronic morphine treatment on the expression and function of some BBB markers in the rat.
Gene_expression (expression) of BBB associated with morphine
3) Confidence 0.12 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18761714 Disease Relevance 0 Pain Relevance 0.42
Morphine may affect the properties of the blood-brain barrier (BBB) by modifying the expression of certain BBB markers.
Gene_expression (expression) of BBB in brain associated with morphine
4) Confidence 0.12 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18761714 Disease Relevance 0 Pain Relevance 0.36
Stress-induced activation of neurons in the ventromedial arcuate nucleus: a blood-brain-CSF interface of the hypothalamus.
Gene_expression (interface) of blood-brain-CSF in brain associated with stress
5) Confidence 0.06 Published 2008 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 19120091 Disease Relevance 0.29 Pain Relevance 0.13
The extent of BBB transport, expressed as the ratio between clearance into the brain and clearance out of the brain (CL(in)/CL(out)), was estimated as 0.29 on both days, indicating that efflux transporters act on M6G at the BBB.
Gene_expression (expressed) of BBB in brain
6) Confidence 0.06 Published 2005 Journal Eur J Pharm Sci Section Abstract Doc Link 15626577 Disease Relevance 0 Pain Relevance 0.15
Bypassing the BBB
Gene_expression (Bypassing) of BBB
7) Confidence 0.06 Published 2008 Journal AAPS J Section Body Doc Link PMC2751463 Disease Relevance 0.62 Pain Relevance 0.19
Pharmacological oriented strategies involve drug modification, pro-drug synthesis, and the use of pharmacological agents to breach the BBB, such as bradykinin agonists, like RMP-7.
Gene_expression (breach) of BBB associated with agonist and bradykinin
8) Confidence 0.06 Published 2008 Journal AAPS J Section Body Doc Link PMC2751463 Disease Relevance 0.09 Pain Relevance 0.33
Unfortunately, very few therapeutic agents currently available do cross the BBB and enters the CNS.
Gene_expression (cross) of BBB
9) Confidence 0.06 Published 2008 Journal AAPS J Section Abstract Doc Link PMC2751463 Disease Relevance 0 Pain Relevance 0
The current study investigated effects of lambda-carrageenan-induced inflammatory pain (CIP) on BBB expression of ICAM-1.
Gene_expression (expression) of BBB associated with ipn
10) Confidence 0.04 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16199477 Disease Relevance 0.76 Pain Relevance 0.93
In addition, or alternatively, to increased production of certain gene products, key elements of the BBB might become reduced, and in preliminary experiments we have found a decrease in the level of aquaporin-4, a component of the BBB, preceding the increase in permeability [19].
Gene_expression (production) of BBB
11) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC2984489 Disease Relevance 0 Pain Relevance 0.41
Previous studies showed that peripheral inflammatory pain increased blood-brain barrier (BBB) permeability and altered tight junction protein expression and the delivery of opioid analgesics to the brain.
Gene_expression (expression) of BBB in blood associated with analgesic, ipn and opioid
12) Confidence 0.03 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16199477 Disease Relevance 0.54 Pain Relevance 0.73
Evans Blue binds to albumin in the circulation producing a molecular complex of sufficient molecular size that it does not cross the intact BSCB or BBB.
Gene_expression (producing) of BBB
13) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC2984489 Disease Relevance 1.13 Pain Relevance 0.76
In a related study, we have shown that ALA-mediated PDT at relatively high fluences (9–26 J) could also produce BBB degradation [28].
Gene_expression (produce) of BBB
14) Confidence 0.02 Published 2009 Journal J Neurooncol Section Body Doc Link PMC2773371 Disease Relevance 0.07 Pain Relevance 0
The effects of the vascular endothelial growth factor (VEGF) inhibitor, Cyclo-VEGI on expression of VEGF, microgliosis and astrogliosis, blood-brain barrier (BBB) integrity and neuronal viability have been studied following intra-striatal injection of the excitotoxin, quinolinic acid (QUIN).
Gene_expression (expression) of BBB in brain
15) Confidence 0.01 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2430697 Disease Relevance 0.26 Pain Relevance 0.23
Effects of the VEGF receptor antagonist Cyclo-VEGI were determined on VEGF expression, gliosis, permeability of Evans blue dye and plasma protein fibrinogen through blood-brain barrier (BBB) and as a pharmacological modulator of neuronal viability.
Spec (determined) Gene_expression (expression) of BBB in blood associated with antagonist and gliosis
16) Confidence 0.01 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430697 Disease Relevance 0.35 Pain Relevance 0.09
Furthermore, Oatp2 is strongly expressed at the rat blood-brain barrier (BBB).
Gene_expression (expressed) of BBB in brain
17) Confidence 0.01 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10871297 Disease Relevance 0 Pain Relevance 0.46

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox