INT89104

Context Info Confidence 0.44 First Reported 2000 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 29 Total Number 30 Disease Relevance 13.67 Pain Relevance 5.12

aging (TGFB1) enzyme binding (TGFB1) embryo development (TGFB1) cytoplasm (TGFB1) extracellular space (TGFB1) extracellular region (TGFB1)

Anatomy Link Frequency articular 3 cartilage 2 chondrocytes 1 G/G 1 astrocyte 1 TGFB1 (Homo sapiens)

Pain Link Frequency Relevance Heat aspirin 310 100.00 dexamethasone 10 100.00 Opioid 8 99.90 Enkephalin 2 99.64 Inflammation 218 98.08 fibrosis 86 97.92 Osteoarthritis 117 96.80 Chronic pancreatitis 1 96.24 cytokine 94 93.36 Angina 3 90.08

Disease Link Frequency Relevance Heat Cancer 154 100.00 Necrosis 9 100.00 Cardiovascular Disease 7 99.04 Asthma 84 99.00 Pancreatitis 3 98.92 Osteoarthritis 126 98.72 INFLAMMATION 242 98.08 Fibrosis 108 97.92 Apoptosis 118 97.68 Arthritis 123 97.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Kappa opioids and TGFbeta1 interact in human endometrial cells.

TGFbeta1 Binding (interact) of associated with enkephalin and opioid

1) Confidence 0.44 Published 2000 Journal Mol. Hum. Reprod. Section Title Doc Link 10871647 Disease Relevance 0.07 Pain Relevance 0.88

However, the interaction between dexamethasone and TGF-beta1 is still unknown.

TGF-beta1 Binding (interaction) of associated with dexamethasone

2) Confidence 0.42 Published 2007 Journal J Endod Section Abstract Doc Link 17931932 Disease Relevance 0.18 Pain Relevance 0.59

To determine whether TGF-?

TGF Spec (determine) Binding (determine) of

3) Confidence 0.36 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165041 Disease Relevance 0.55 Pain Relevance 0.23

For example, ErbB3, fos, TGF?

TGF Binding (example) of

4) Confidence 0.32 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.41 Pain Relevance 0

Intra-articular TGF-?

TGF Binding (Intra) of in articular

5) Confidence 0.31 Published 2003 Journal Arthritis Res Ther Section Abstract Doc Link PMC165041 Disease Relevance 0.47 Pain Relevance 0.07

Intra-articular TGF-?

TGF Binding (Intra) of in articular

6) Confidence 0.31 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165041 Disease Relevance 0.87 Pain Relevance 0.28

Intra-articular TGF-?

TGF Binding (Intra) of in articular

7) Confidence 0.31 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165041 Disease Relevance 0.66 Pain Relevance 0.21

1 is strongly associated with TGF-?

TGF Binding (associated) of

8) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842433 Disease Relevance 0 Pain Relevance 0.08

Bone Morphogenetic Protein 2 (BMP2) and TGF?

TGF Binding (Bone) of

9) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0.20 Pain Relevance 0.10

The association of ASA and TGF-?

TGF Binding (association) of associated with aspirin

10) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842433 Disease Relevance 0.28 Pain Relevance 0.68

In the present report we find an ASA-mediated TGF-?

TGF Binding (find) of associated with aspirin

11) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842433 Disease Relevance 0.32 Pain Relevance 0.39

signalling is initiated via the binding of TGF-  ?

TGF Binding (binding) of

12) Confidence 0.22 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 0.65 Pain Relevance 0

, TGFB1 binds to TGFBR2 which then leads to recruitment via phosphorylation of the type I TGF- ?

TGFB1 Binding (binds) of

13) Confidence 0.22 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 0.62 Pain Relevance 0

Osteoarthritic chondrocytes also express, besides catabolic factors, anabolic factors such as transforming growth factor beta (TGF?)

transforming growth factor beta Binding (factors) of in chondrocytes associated with osteoarthritis

14) Confidence 0.21 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.88 Pain Relevance 0.42

Gene filter data from two patients also showed similar pattern of collagen, type 1 (alpha 2), fibronectin 1, MMP-1, TGF-?

TGF Binding (pattern) of

15) Confidence 0.19 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 0.69 Pain Relevance 0.03

1-509C>T polymorphism was reported to have a significant association with the frequency of rhinosinusitis in AIA patients.25 Furthermore, our data on the gene-gene interaction between IL-10 and TGFb1 suggest its association with the development of AIA with rhinosinusitis.26 In this study, we found a significantly higher frequency of rhinosinusitis in AIA associated with the three IL-13 polymorphisms.

TGFb1 Binding (association) of associated with asthma

16) Confidence 0.17 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 1.15 Pain Relevance 0

The purpose of this study was to evaluate the levels of nitric oxide (NO), IL-4, TGF-beta, tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma) in chronic periapical lesions and to determine their possible association with clinical and radiographic parameters.

TGF-beta Binding (association) of associated with necrosis and cancer

17) Confidence 0.17 Published 2010 Journal J. Oral Pathol. Med. Section Abstract Doc Link 20102461 Disease Relevance 0.35 Pain Relevance 0.04

Indirect immunohistochemical labelling was performed to reveal binding of primary antibodies against endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS) and TGF-beta.

TGF-beta Binding (binding) of

18) Confidence 0.11 Published 2006 Journal Acta Histochem. Section Abstract Doc Link 16762404 Disease Relevance 0.26 Pain Relevance 0.07

Transforming growth factor-beta-1 variants are not associated with chronic nonalcoholic pancreatitis.

Transforming growth factor-beta-1 Binding (associated) of associated with pancreatitis

19) Confidence 0.09 Published 2005 Journal Pancreatology Section Title Doc Link 15802940 Disease Relevance 0.57 Pain Relevance 0.19

Parallel experiments designed to generate cartilage in vivo using the same model, however, necessitated subcutaneous implantation of MPCs combined with transforming growth factor (TGF)-?

TGF Binding (combined) of in cartilage

20) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0.20 Pain Relevance 0.03

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