INT89105

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 27
Total Number 29
Disease Relevance 4.32
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gapdh) cytoplasm (Gapdh)
Anatomy Link Frequency
internal 3
uterus 1
brain 1
adipose tissue 1
cornea 1
Gapdh (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 11 96.36 Very High Very High Very High
member 8 19 95.04 Very High Very High Very High
Catecholamine 46 84.80 Quite High
endometriosis 117 83.84 Quite High
chemokine 14 80.00 Quite High
Dopamine 5 71.80 Quite High
cytokine 40 71.12 Quite High
imagery 7 66.16 Quite High
Opioid 5 62.56 Quite High
amygdala 4 61.76 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 154 99.64 Very High Very High Very High
Sprains And Strains 274 99.44 Very High Very High Very High
Injury 40 98.64 Very High Very High Very High
Apoptosis 20 97.80 Very High Very High Very High
Obesity 33 96.36 Very High Very High Very High
Aspergillus Infection 6 95.40 Very High Very High Very High
Candida Infection 6 94.40 High High
Infection 18 93.52 High High
Chemical Burns 10 92.64 High High
Stress 98 92.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All data were normalized with GAPDH gene expression values.
Gene_expression (expression) of GAPDH
1) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0 Pain Relevance 0
(GAPDH expression in control mice and acutely stressed animals was comparable, e.g. in brain IDO1-signal detectable at cycle: 17.33±1.46 in non-stressed mice, 16.83±1.73 at 2-h and 16.38±0.58 6-h after acute stress).
Gene_expression (expression) of GAPDH in brain associated with stress
2) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.09 Pain Relevance 0.03
The 394-bp product corresponding to MMP7 and a 240-bp product for glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as an internal control were detected.
Gene_expression (product) of glyceraldehyde-3-phosphate dehydrogenase in internal
3) Confidence 0.75 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2805671 Disease Relevance 0 Pain Relevance 0
QuantiTect primer assays (Qiagen Ltd, UK) were used: hGAPDH (QT01192646); hRPL32 (QT00046088); hSGPP2 (QT00041832), hJAG1 (QT00031948), mJAM3 (QT00024997), mGAPDH (QT 0199388); mRPL32 (QT0131992) mSGPP2 (QT 01044204).
Gene_expression (used) of GAPDH
4) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0 Pain Relevance 0
QuantiTect primer assays (Qiagen Ltd, UK) were used: hGAPDH (QT01192646); hRPL32 (QT00046088); hSGPP2 (QT00041832), hJAG1 (QT00031948), mJAM3 (QT00024997), mGAPDH (QT 0199388); mRPL32 (QT0131992) mSGPP2 (QT 01044204).
Gene_expression (used) of GAPDH
5) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941452 Disease Relevance 0 Pain Relevance 0
Te is the Ct cycle number of an interested gene such as Runx1 observed in a sample of salivary gland from the treated group, Tn is the Ct cycle number of the housekeeping genes GAPDH observed in the same sample while Ce is the average Ct cycle number of the same target gene such as Runx1 observed in a sample in the control group, Cn is the average Ct cycle number of housekeeping gene GAPDH in the same sample.
Gene_expression (observed) of GAPDH in salivary gland
6) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691577 Disease Relevance 0 Pain Relevance 0
 ; rat GAPDH: FOR 5?
Gene_expression (rat) of GAPDH
7) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2636885 Disease Relevance 0.17 Pain Relevance 0.19
-tubulin, and GAPDH) using the comparative C(t) (??
Gene_expression (using) of GAPDH
8) Confidence 0.65 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2592819 Disease Relevance 0 Pain Relevance 0
The primer and probe sequences for angiogenin are shown in Table 2, and commercially synthesized primer and probe were used for glyceraldehyde 3-phosphate dehydrogenase (GAPDH) (Human GAPDH Endogenous Control, Applied Biosystems).
Gene_expression (used) of GAPDH
9) Confidence 0.65 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2579997 Disease Relevance 0.22 Pain Relevance 0.03
For Gapdh, primers Gapdh_ex6F and Gapdh_ex7R were used.
Gene_expression (used) of Gapdh
10) Confidence 0.65 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2265474 Disease Relevance 0 Pain Relevance 0
Primers were also designed for the reference genes GAPDH (Glyceraldehyde-3-phosphate dehydrogenase) and ACTB (Actin, beta); all primer sequences are available in the Supplementary Material (see Additional file1).
Gene_expression (designed) of GAPDH
11) Confidence 0.65 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1858698 Disease Relevance 0 Pain Relevance 0.03
For Gapdh, primers Gapdh_ex6F and Gapdh_ex7R were used.
Gene_expression (used) of Gapdh
12) Confidence 0.65 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2265474 Disease Relevance 0 Pain Relevance 0
Only samples positive for GAPDH expression were considered, and we designed specific human myogenic primers in unique regions based on deposited human sequences.
Gene_expression (expression) of GAPDH
13) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0 Pain Relevance 0
For normalization of the data the average of the expression level of four house-keeping genes, GAPDH, HPRT, beta-actin and beta-tubulin, was used.



Gene_expression (expression) of GAPDH
14) Confidence 0.58 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0 Pain Relevance 0
To account for variation in mRNA quantity, the geometric mean of the expression of the two reference genes ACTB and GAPDH [38] were included as the covariate (G) in the model [39].
Gene_expression (expression) of GAPDH
15) Confidence 0.58 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1858698 Disease Relevance 0 Pain Relevance 0
GAPDH and HPRT were shown as stable expressing genes across strains (Loos et al., 2009).
Gene_expression (expressing) of GAPDH associated with sprains and strains
16) Confidence 0.58 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2901093 Disease Relevance 0.17 Pain Relevance 0
The 420-bp product corresponding to Glycodelin and a 240-bp product for glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as an internal control were detected.
Gene_expression (product) of glyceraldehyde-3-phosphate dehydrogenase in internal
17) Confidence 0.58 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2805671 Disease Relevance 0 Pain Relevance 0
The 150-bp product corresponding to Plexin B1 and a 240-bp product for glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as an internal control were detected.
Gene_expression (product) of glyceraldehyde-3-phosphate dehydrogenase in internal
18) Confidence 0.58 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2805671 Disease Relevance 0 Pain Relevance 0
The expression values obtained in each experimental sample were also normalized taking into consideration the expression levels of the GAPDH gene.
Gene_expression (expression) of GAPDH
19) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 0.52 Pain Relevance 0
The expression level of each gene was compared to the levels of the housekeeping gene glyceraldehyde 3-phophate dehydrogenase (GAPDH) (3 spots in each array), whereas negative values were transformed to zero.
Gene_expression (levels) of GAPDH
20) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0 Pain Relevance 0

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