INT89113

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Context Info
Confidence 0.62
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 6.83
Pain Relevance 4.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cftr) transport (Cftr) ATPase activity (Cftr)
enzyme binding (Cftr) protein complex (Cftr) transmembrane transport (Cftr)
Anatomy Link Frequency
sweat glands 1
vas deferens 1
glands 1
Cftr (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 246 100.00 Very High Very High Very High
sodium channel 19 100.00 Very High Very High Very High
cINOD 6 99.90 Very High Very High Very High
Inflammation 29 99.84 Very High Very High Very High
substance P 9 98.40 Very High Very High Very High
anesthesia 4 96.08 Very High Very High Very High
Chronic pancreatitis 10 95.56 Very High Very High Very High
aspirin 12 87.56 High High
Bile 159 69.84 Quite High
antagonist 1 69.08 Quite High
Disease Link Frequency Relevance Heat
Cystic Fibrosis 246 100.00 Very High Very High Very High
INFLAMMATION 24 99.84 Very High Very High Very High
Infection 11 99.68 Very High Very High Very High
Pancreatitis 22 98.50 Very High Very High Very High
Targeted Disruption 31 94.68 High High
Bronchiectasis 1 93.36 High High
Respiratory Disease 2 93.32 High High
Disease 18 92.04 High High
Respiratory Failure 2 89.28 High High
Pulmonary Disease 3 87.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since CFTR regulation is qualitatively similar in human and mouse glands, loss of this local regulation in CF may contribute to reduced innate defenses in CF airways.
Regulation (regulation) of CFTR in glands
1) Confidence 0.62 Published 2008 Journal Pflugers Arch. Section Abstract Doc Link 18509672 Disease Relevance 0.13 Pain Relevance 0.39
Airway inflammation is not different in CFTR -/- versus CFTR +/+ mice
Neg (not) Regulation (different) of CFTR associated with inflammation
2) Confidence 0.45 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.42 Pain Relevance 0.23
The results indicate that NSAIDs can regulate both CFTR gene expression and the function of CFTR-related chloride transport, and suggest that NSAIDs act via multiple transduction pathways.



Regulation (regulate) of CFTR associated with cinod
3) Confidence 0.43 Published 1999 Journal Mediators Inflamm Section Abstract Doc Link PMC1781806 Disease Relevance 0.83 Pain Relevance 0.92
F508 mutation is the most common genetic disturbance affecting the CFTR gene. ?
Regulation (affecting) of CFTR gene
4) Confidence 0.43 Published 2001 Journal BMC Gastroenterol Section Body Doc Link PMC59644 Disease Relevance 0.40 Pain Relevance 0.20
Mutations of CFTR gene are responsible for cystic fibrosis (CF) and other clinical conditions such as congenital absence of the vas deferens (CAVD), chronic pancreatitis (IP), and idiopathic disseminated bronchiectasis (DBE) classified as CFTR-related disorders.
Regulation (responsible) of CFTR gene in vas deferens associated with fibrosis, bronchiectasis, cystic fibrosis and chronic pancreatitis
5) Confidence 0.41 Published 2005 Journal Genet. Test. Section Abstract Doc Link 16379540 Disease Relevance 0.60 Pain Relevance 0.30
shRNAs targeting CFTR and individually cloned into plko.1-puromycin vector (Open Biosystems, Huntsville, AL) were used to generate lentiviral particles in HEK293FT packaging cells.
Regulation (targeting) of CFTR
6) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.10 Pain Relevance 0
Many idiopathic pancreatitis patients have compound heterozygote genotypes in which both copies of the CFTR gene are abnormal.
Regulation (abnormal) of CFTR associated with pancreatitis
7) Confidence 0.27 Published 2000 Journal Med. Clin. North Am. Section Abstract Doc Link 10872419 Disease Relevance 1.05 Pain Relevance 0.56
For example, regulation of other ion channels, such as the epithelial sodium channel and the outwardly rectified chloride channel, are well-described functions of CFTR [3,4].
Regulation (regulation) of CFTR associated with sodium channel
8) Confidence 0.26 Published 2001 Journal BMC Gastroenterol Section Body Doc Link PMC59644 Disease Relevance 0.50 Pain Relevance 0.30
Of course, a more widespread perturbation of ion channel regulation in the absence of CFTR is also a possibility, as CFTR has been demonstrated to be a master regulator of such diverse proteins as the Na/K pump [41], the basolateral Na/K/2Cl co-transporter [42], and the inducible nitric oxide synthase [43].


Regulation (regulation) of CFTR
9) Confidence 0.26 Published 2001 Journal BMC Gastroenterol Section Body Doc Link PMC59644 Disease Relevance 0.33 Pain Relevance 0.33
Thus, CFTR mutations affect the respiratory, gastrointestinal, hepatobiliary, and reproductive systems as well as sweat glands.
Regulation (affect) of CFTR in sweat glands
10) Confidence 0.05 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2817861 Disease Relevance 0.99 Pain Relevance 0.34
In addition, alterations in the cystic fibrosis (CFTR) gene are associated with idiopathic pancreatitis.
Regulation (alterations) of CFTR associated with fibrosis, pancreatitis and cystic fibrosis
11) Confidence 0.04 Published 2008 Journal Rev Endocr Metab Disord Section Abstract Doc Link 18604651 Disease Relevance 1.49 Pain Relevance 0.45

General Comments

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