INT89114

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Context Info
Confidence 0.37
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 13
Total Number 16
Disease Relevance 11.29
Pain Relevance 4.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cftr) transport (Cftr) ATPase activity (Cftr)
enzyme binding (Cftr) protein complex (Cftr) transmembrane transport (Cftr)
Anatomy Link Frequency
lung 1
Cftr (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 244 100.00 Very High Very High Very High
Chronic pancreatitis 114 99.76 Very High Very High Very High
sodium channel 10 99.24 Very High Very High Very High
Inflammation 82 98.04 Very High Very High Very High
cytokine 23 96.44 Very High Very High Very High
bradykinin 1 87.68 High High
Pain 8 85.60 High High
Bioavailability 6 83.60 Quite High
Pain management 3 78.24 Quite High
Bile 59 76.36 Quite High
Disease Link Frequency Relevance Heat
Cystic Fibrosis 242 100.00 Very High Very High Very High
Exocrine Pancreatic Insufficiency 7 100.00 Very High Very High Very High
Vibrio Infection 39 99.84 Very High Very High Very High
Pancreatitis 154 99.76 Very High Very High Very High
Pulmonary Disease 64 99.52 Very High Very High Very High
Fibrosis 2 98.64 Very High Very High Very High
Disease 65 98.28 Very High Very High Very High
INFLAMMATION 89 98.04 Very High Very High Very High
Targeted Disruption 21 96.72 Very High Very High Very High
Congenital Anomalies 12 96.26 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, a recent study demonstrated that CFTR is also expressed in tracheal SMC and may contribute to bronchodilation [36].
CFTR Binding (contribute) of
1) Confidence 0.37 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.94 Pain Relevance 0.32
Previous evidence has suggested that CFTR interacted with AMPK, which is involved in the regulation of cellular energy homeostasis [48], [49].
CFTR Binding (interacted) of
2) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0 Pain Relevance 0
This article summarizes the evidence associating these abnormal CFTR genotypes with idiopathic chronic pancreatitis and reviews the implications of this association for the pathogenesis, classification, and prevention of pancreatitis.
CFTR Binding (associating) of associated with pancreatitis and chronic pancreatitis
3) Confidence 0.36 Published 2000 Journal Med. Clin. North Am. Section Abstract Doc Link 10872419 Disease Relevance 1.12 Pain Relevance 0.55
BACKGROUND & AIMS: Cystic fibrosis transmembrane regulator (CFTR) gene mutations are associated with pancreatic insufficiency and pancreatitis.
Cystic fibrosis transmembrane regulator Binding (associated) of associated with fibrosis, exocrine pancreatic insufficiency, pancreatitis, cystic fibrosis and chronic pancreatitis
4) Confidence 0.35 Published 2005 Journal Gastroenterology Section Abstract Doc Link 16083720 Disease Relevance 0.83 Pain Relevance 0.40
BACKGROUND & AIMS: Cystic fibrosis transmembrane regulator (CFTR) gene mutations are associated with pancreatic insufficiency and pancreatitis.
CFTR Binding (associated) of associated with fibrosis, exocrine pancreatic insufficiency, pancreatitis, cystic fibrosis and chronic pancreatitis
5) Confidence 0.35 Published 2005 Journal Gastroenterology Section Abstract Doc Link 16083720 Disease Relevance 0.83 Pain Relevance 0.40
Other genes, such as the anionic trypsinogen (PRSS2), the serine protease inhibitor, Kazal type 1 (SPINK1) and the cystic fibrosis transmembrane conductance regulator (CFTR) have been found to be associated with chronic pancreatitis (idiopathic and hereditary) as well.
cystic fibrosis transmembrane conductance regulator Binding (associated) of associated with fibrosis, cystic fibrosis and chronic pancreatitis
6) Confidence 0.34 Published 2007 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC1774562 Disease Relevance 1.77 Pain Relevance 1.05
F508-CFTR but also I?
CFTR Binding (F508) of
7) Confidence 0.32 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2954907 Disease Relevance 0.85 Pain Relevance 0.20
Moreover, our recent data suggests that selective proteasome inhibition also helps in controlling chronic inflammation that will be required for treating the patients with chronic lung disease, as rescuing misfolded CFTR may not be sufficient for favorable therapeutic outcome.
CFTR Binding (sufficient) of in lung associated with pulmonary disease and inflammation
8) Confidence 0.32 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2954907 Disease Relevance 0.68 Pain Relevance 0.14
F508 CFTR is associated with decreased membrane sialic acid residues in the ?
F508 CFTR Binding (associated) of
9) Confidence 0.31 Published 2009 Journal The Open Respiratory Medicine Journal Section Abstract Doc Link PMC2703207 Disease Relevance 0.56 Pain Relevance 0.20
F508 CFTR also have a lower level of GM1, as evidenced by decreased binding to cholera toxin.
F508 CFTR Binding (binding) of associated with vibrio infection
10) Confidence 0.31 Published 2009 Journal The Open Respiratory Medicine Journal Section Body Doc Link PMC2703207 Disease Relevance 0.19 Pain Relevance 0.05
Co-localization of CFTR and ENaC suggests that direct protein-protein interactions allow CFTR to closely regulate the activity of this channel [39,40].
CFTR Binding (interactions) of associated with sodium channel
11) Confidence 0.30 Published 2001 Journal BMC Gastroenterol Section Body Doc Link PMC59644 Disease Relevance 0.39 Pain Relevance 0.40
F508-CFTR and I?
CFTR Binding (F508) of
12) Confidence 0.28 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2954907 Disease Relevance 0.52 Pain Relevance 0.08
Abnormalities in sialylation of cells transfected with mutant CFTR and secretions of patients with CF have been described [9]; however, it has not been clear whether this phenomenon has been directly mediated by the presence of neuraminidases in colonizing bacteria or by the abnormal CFTR.
CFTR Spec (whether) Binding (mediated) of associated with fibrosis and congenital anomalies
13) Confidence 0.27 Published 2009 Journal The Open Respiratory Medicine Journal Section Body Doc Link PMC2703207 Disease Relevance 0.81 Pain Relevance 0.29
With respect to chronic pancreatitis, this review focuses on its association with mutations in the cystic fibrosis conductance regulator gene and the mechanisms of pancreatic fibrosis.
cystic fibrosis conductance regulator gene Binding (association) of associated with fibrosis, cystic fibrosis and chronic pancreatitis
14) Confidence 0.25 Published 2001 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 11768555 Disease Relevance 0.82 Pain Relevance 0.40
In addition, there are several other phenotypes associated with CFTR gene mutations, such as idiopathic chronic pancreatitis.
CFTR gene Binding (associated) of associated with chronic pancreatitis
15) Confidence 0.22 Published 2004 Journal Hum. Mutat. Section Abstract Doc Link 15241793 Disease Relevance 0.55 Pain Relevance 0.33
Remarkably, in all three affected individuals, the SPINK1 deletion was found to be co-inherited with a heterozygous p.L997F missense mutation in the unlinked CFTR gene, a lesion previously reported to be associated with a variety of cystic fibrosis-related diseases including idiopathic pancreatitis.
CFTR gene Binding (associated) of associated with fibrosis, pancreatitis, cystic fibrosis and disease
16) Confidence 0.01 Published 2007 Journal Mol. Genet. Metab. Section Abstract Doc Link 17681820 Disease Relevance 0.44 Pain Relevance 0.20

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