INT89116

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Context Info
Confidence 0.43
First Reported 2000
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 6.62
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VEGFA) growth (VEGFA) extracellular region (VEGFA)
proteinaceous extracellular matrix (VEGFA) cytoplasm (VEGFA)
Anatomy Link Frequency
cochlea 2
chondrocytes 2
endothelial cell 2
uterine 2
inner ear 2
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 1 100.00 Very High Very High Very High
Osteoarthritis 50 99.84 Very High Very High Very High
agonist 108 97.56 Very High Very High Very High
antagonist 14 88.56 High High
rheumatoid arthritis 109 83.76 Quite High
cva 3 81.84 Quite High
pulpitis 2 81.44 Quite High
cytokine 37 79.68 Quite High
Arthritis 13 78.48 Quite High
Inflammation 55 66.96 Quite High
Disease Link Frequency Relevance Heat
Ovarian Cancer 100 100.00 Very High Very High Very High
Leukemia 3 100.00 Very High Very High Very High
Gastrointestinal Stromal Tumor 1 100.00 Very High Very High Very High
Osteoarthritis 50 99.84 Very High Very High Very High
Ganglion Cysts 34 99.30 Very High Very High Very High
Cancer 128 98.72 Very High Very High Very High
Disease 52 98.00 Very High Very High Very High
Solid Tumor 10 97.08 Very High Very High Very High
Osteophyte 5 96.72 Very High Very High Very High
Vascular Malformations 1 95.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Simulation of VEGF-trapping did not recapitulate sVEGFR1's anti-angiogenic potential
Neg (not) Regulation (recapitulate) of Positive_regulation (Simulation) of VEGF-trapping
1) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0.16 Pain Relevance 0
Notably, LPS-induced VEGF is associated with phosphorylation of protein kinase C (PKC zeta) and extracellular signal-regulator kinase (ERK1/2) and is dependent upon MAPK activation.
Regulation (dependent) of Positive_regulation (induced) of VEGF associated with kinase c
2) Confidence 0.41 Published 2010 Journal J. Dent. Res. Section Abstract Doc Link 20110511 Disease Relevance 0.07 Pain Relevance 0.20
However, the signalling pathways which control transcriptional induction of VEGF in OA chondrocytes are still being dissected.
Regulation (control) of Positive_regulation (induction) of VEGF in chondrocytes associated with osteoarthritis
3) Confidence 0.40 Published 2010 Journal The Open Rheumatology Journal Section Body Doc Link PMC2845788 Disease Relevance 1.01 Pain Relevance 0.17
We then examined what type cochlear cells were responsible for VEGF increase in the cochlea in response to local application of EP2 or EP4 agonists.
Spec (examined) Regulation (responsible) of Positive_regulation (increase) of VEGF in cochlea associated with agonist
4) Confidence 0.36 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.13 Pain Relevance 0.28
There are various reasons for the ineffectiveness of imatinib monotherapy in ovarian cancer: downregulation of c-kit and PDGFR may lead to induction of VEGF, inhibition of a single tyrosine kinase might be insufficient to impact downstream signaling cascades, and the molecular targets of imatinib might not be relevant in the occurrence of ovarian cancer in comparison with gastrointestinal stromal tumor or chronic myeloid leukemia where a single specific mutation or a translocation, respectively, can be responsible for the genesis of these two cancers [62].
Regulation (responsible) of Positive_regulation (induction) of VEGF associated with leukemia, cancer, ovarian cancer and gastrointestinal stromal tumor
5) Confidence 0.36 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2804796 Disease Relevance 1.34 Pain Relevance 0
With respect to pathogenesis, among others, upregulation of the glykopeptide VEGF-D, a vascular endothelial growth factor, seems to be responsible for the endothelial cell proliferation [4].
Spec (seems) Regulation (responsible) of Positive_regulation (upregulation) of vascular endothelial growth factor in endothelial cell
6) Confidence 0.26 Published 2008 Journal Head Face Med Section Body Doc Link PMC2533304 Disease Relevance 1.61 Pain Relevance 0.06
Other agents which target VEGF receptors, such as, chimerized anti-KDR antibody, VEGF-Trap, and a synthetic ribozyme of Flt-1, are also undergoing phase I or II trials for the treatment of solid tumors and cancer [36].
Regulation (target) of Positive_regulation (ribozyme) of VEGF associated with cancer and solid tumor
7) Confidence 0.22 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2638142 Disease Relevance 1.46 Pain Relevance 0.37
Immunostaining for VEGF showed that the strongest response to EP2 or EP4 stimulation occurred in the spiral ganglion neurons, suggesting that they are responsible for increasing the VEGF levels in the inner ear.
Regulation (responsible) of Positive_regulation (increasing) of VEGF in inner ear associated with ganglion cysts
8) Confidence 0.16 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.25 Pain Relevance 0.14
As functional effects of TLR2 activation in RASFs, induction of vascular endothelial growth factor (VEGF) and IL-8 production were demonstrated after stimulation with bacterial peptidoglycan (a known ligand of TLR2) [5].
Regulation (effects) of Positive_regulation (induction) of VEGF
9) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.57 Pain Relevance 0.27
CONCLUSIONS: The up-regulation of VEGF isoforms during the progression of uterine-peritoneal adhesion may be a compensatory mechanism regulating angiogenesis in order to provide nutrients and oxygen to the injured tissues.


Regulation (regulating) of Positive_regulation (up-regulation) of VEGF in uterine
10) Confidence 0.04 Published 2000 Journal Am. J. Reprod. Immunol. Section Body Doc Link 10872610 Disease Relevance 0 Pain Relevance 0

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