INT89126

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Context Info
Confidence 0.45
First Reported 2000
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 2.50
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

anatomical structure formation involved in morphogenesis (BMP7) extracellular space (BMP7) growth (BMP7)
extracellular region (BMP7)
Anatomy Link Frequency
cartilage 1
epithelial cells 1
dental pulps 1
BMP7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 58 99.38 Very High Very High Very High
pulpitis 1 96.88 Very High Very High Very High
Inflammation 12 79.44 Quite High
cytokine 30 78.56 Quite High
Eae 2 64.88 Quite High
Pain 36 54.24 Quite High
Substantia nigra 6 53.36 Quite High
visual analogue scale 3 19.72 Low Low
Analgesic 3 16.92 Low Low
backache 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 7 100.00 Very High Very High Very High
Frailty 30 99.38 Very High Very High Very High
Pancreatic Cancer 37 98.40 Very High Very High Very High
Pulpitis 1 96.88 Very High Very High Very High
Cancer 38 96.76 Very High Very High Very High
Breast Cancer 10 96.64 Very High Very High Very High
Mouth Cancer 1 95.60 Very High Very High Very High
Focal Cartilage Defect 6 91.92 High High
Hyperplasia 1 80.40 Quite High
INFLAMMATION 11 79.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OA cartilage explants contain up-regulated receptors for BMP-7, and addition of BMP-7 to human OA cartilage explants results in anabolic activity by increasing extracellular matrix production [15].
Regulation (regulated) of BMP-7 in cartilage associated with osteoarthritis
1) Confidence 0.45 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958989 Disease Relevance 0.62 Pain Relevance 0.23
Given that pulp cells in the inflamed tissues likely retain the capacity to respond to exogenous BMP-7, it is possible that insufficient active recombinant protein is available to induce tissue formation in experimentally inflamed dental pulps.
Regulation (respond) of BMP-7 in dental pulps
2) Confidence 0.45 Published 2000 Journal Eur. J. Oral Sci. Section Abstract Doc Link 10872990 Disease Relevance 0.18 Pain Relevance 0.14
The present study was undertaken to investigate the effects of bone morphogenetic protein-7 (BMP-7), also named osteogenic protein-1 (OP-1), on the progression of a striatal 6-hydroxydopamine (6-OHDA) lesion.
Spec (investigate) Regulation (effects) of bone morphogenetic protein-7
3) Confidence 0.29 Published 2004 Journal Brain Res. Section Abstract Doc Link 15126112 Disease Relevance 0 Pain Relevance 0.06
The present study was undertaken to investigate the effects of bone morphogenetic protein-7 (BMP-7), also named osteogenic protein-1 (OP-1), on the progression of a striatal 6-hydroxydopamine (6-OHDA) lesion.
Spec (investigate) Regulation (effects) of osteogenic protein-1
4) Confidence 0.29 Published 2004 Journal Brain Res. Section Abstract Doc Link 15126112 Disease Relevance 0 Pain Relevance 0.09
The concentrations of BMP-2 and BMP-7 were determined by ELISA.
Regulation (concentrations) of BMP-7
5) Confidence 0.23 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2920860 Disease Relevance 0 Pain Relevance 0
It was recently reported that the bone morphogenic protein (BMP7) gene, which controls cell proliferation and apoptosis of mammary epithelial cells, is a direct target of LMO4 [22].
Regulation (target) of BMP7 in epithelial cells associated with apoptosis
6) Confidence 0.22 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2628350 Disease Relevance 1.39 Pain Relevance 0
There was no statistically significant change in BMP-7 levels at day 1 post surgery (8.56 ± 24.22 pg/ml vs. 57.25 ± 137.89 pg/ml, n = 28, p = 0.09, power 46.56%), and no significant difference of BMP-7 levels comparing day 1 and day 2 (6.53 ± 7.23 pg/ml, n = 6, p = 0.26, power 5.98%) after the operation.


Neg (no) Regulation (change) of BMP-7
7) Confidence 0.20 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.15 Pain Relevance 0.07
A few studies have addressed the effect of osteogenic protein-1 (OP-1) on AF cells cultured in alginate beads [72, 116].
Regulation (effect) of osteogenic protein-1
8) Confidence 0.05 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2899423 Disease Relevance 0.08 Pain Relevance 0
A few studies have addressed the effect of osteogenic protein-1 (OP-1) on AF cells cultured in alginate beads [72, 116].
Regulation (effect) of OP-1
9) Confidence 0.05 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2899423 Disease Relevance 0.08 Pain Relevance 0

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