INT89131

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Context Info
Confidence 0.58
First Reported 2000
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 20
Total Number 22
Disease Relevance 9.68
Pain Relevance 6.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOS2) oxidoreductase activity (NOS2) nucleus (NOS2)
intracellular (NOS2) cytoplasm (NOS2)
Anatomy Link Frequency
cartilage 2
extracellular matrix 2
neuronal 1
dorsal horn 1
retinal ganglion cell 1
NOS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 20 99.98 Very High Very High Very High
Osteoarthritis 307 99.84 Very High Very High Very High
Dorsal horn neuron 1 99.78 Very High Very High Very High
Inflammation 225 99.70 Very High Very High Very High
Tetrahydrobiopterin 3 99.20 Very High Very High Very High
Pain 28 99.00 Very High Very High Very High
depression 4 98.76 Very High Very High Very High
Dorsal horn 1 98.20 Very High Very High Very High
Morphine 2 98.04 Very High Very High Very High
Antinociceptive 2 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bardet-biedl Syndrome 2 99.92 Very High Very High Very High
Osteoarthritis 318 99.84 Very High Very High Very High
INFLAMMATION 288 99.70 Very High Very High Very High
Pain 32 99.00 Very High Very High Very High
Depression 3 98.76 Very High Very High Very High
Apoptosis 80 98.68 Very High Very High Very High
Glioma 8 98.20 Very High Very High Very High
Ganglion Cysts 7 98.12 Very High Very High Very High
Disease 77 96.28 Very High Very High Very High
Pneumonia 2 95.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using a specific inhibitor of nitric oxide synthase 2 (N-(3-[aminomethyl]benzyl)acetamidine, 1400W) we eliminated the stimulatory effect of endomorphin 1 on nitric oxide release.
Negative_regulation (inhibitor) of nitric oxide synthase 2
1) Confidence 0.58 Published 2007 Journal Neuroscience Section Abstract Doc Link 17197099 Disease Relevance 0.06 Pain Relevance 0.17
Propofol also reduced the LPS-enhanced iNOS mRNA and NF-kappaB protein levels whilst it increased eNOS mRNA expression (P < 0.05).
Negative_regulation (reduced) of iNOS
2) Confidence 0.44 Published 2006 Journal Inflamm. Res. Section Body Doc Link 17122960 Disease Relevance 0 Pain Relevance 0
Furthermore, combined pharmacological inhibition of COX-2 and iNOS in a rat model of tonic pain, produces a synergistic antinociceptive effect [22].
Negative_regulation (inhibition) of iNOS associated with pain and antinociceptive
3) Confidence 0.38 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 1.15 Pain Relevance 0.98
AIM: To determine whether inducible nitric oxide synthase (iNOS) stimulation of human atrial fragments can be diminished by the naturally occurring signal molecules, such as morphine, anandamide, and estrogen.
Negative_regulation (diminished) of inducible nitric oxide synthase associated with morphine
4) Confidence 0.37 Published 2000 Journal Acta Pharmacol. Sin. Section Abstract Doc Link 11324436 Disease Relevance 0 Pain Relevance 0.17
In vivo in an OA animal model, selective inhibition of the inducible nitric oxide synthase (iNOS) provides a protective effect on OA joint tissues more specifically in regard to the degradation of the extracellular matrix and the downregulation of MMP [16].
Negative_regulation (inhibition) of iNOS in extracellular matrix associated with osteoarthritis
5) Confidence 0.34 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.74 Pain Relevance 0.33
In vivo in an OA animal model, selective inhibition of the inducible nitric oxide synthase (iNOS) provides a protective effect on OA joint tissues more specifically in regard to the degradation of the extracellular matrix and the downregulation of MMP [16].
Negative_regulation (inhibition) of inducible nitric oxide synthase in extracellular matrix associated with osteoarthritis
6) Confidence 0.34 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.74 Pain Relevance 0.33
Furthermore, animal models deficient in iNOS establish this enzyme's importance as a pathophysiological mediator of chronic inflammatory diseases [7].
Negative_regulation (deficient) of iNOS associated with inflammation and disease
7) Confidence 0.33 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 1.36 Pain Relevance 0.61
The ET-1-induced NO release occurs via iNOS as shown in Figure 2c: complete inhibition of iNOS by 50 ?
Negative_regulation (inhibition) of iNOS
8) Confidence 0.29 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0 Pain Relevance 0
M allosteric iNOS inhibitor L-NIL, as expected, almost completely inhibited NO release.
Negative_regulation (inhibitor) of iNOS
9) Confidence 0.25 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0 Pain Relevance 0
In order to investigate the possibility of Crinum asiaticum Linne var. japonicum extract as a cosmetic ingredient, we measured its anti-inflammatory effect by its inhibition of iNOS (inducible nitric oxide synthase) and the release of PGE2, IL-6, and IL-8.
Negative_regulation (inhibition) of iNOS associated with inflammation
10) Confidence 0.23 Published 2008 Journal J Cosmet Sci Section Abstract Doc Link 18841306 Disease Relevance 0.60 Pain Relevance 0.21
Moreover, the guanylate cyclase inhibitor LY83583 reduced the NO production as significant differences were found when compared with either the ET-1 stimulation (P < 0.05) or with the control (P < 0.05), and this inhibitor also decreased both the endogenous and ET-1-induced iNOS level (Fig. 2d).
Negative_regulation (decreased) of iNOS
11) Confidence 0.22 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0 Pain Relevance 0
Animal trials of iNOS selective inhibition have demonstrated significantly lower retinal ganglion cell loss in treated versus untreated subjects (Neufeld et al 1999).
Negative_regulation (inhibition) of iNOS in retinal ganglion cell associated with ganglion cysts
12) Confidence 0.19 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699797 Disease Relevance 0.76 Pain Relevance 0.07
Suppression of iNOS activity and NO production is presumably one of the mechanisms by which MMF prevents allograft rejection.12

Pharmacokinetics

Negative_regulation (Suppression) of iNOS
13) Confidence 0.17 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697521 Disease Relevance 0.32 Pain Relevance 0.09
To reduce nitric oxide production, Enkhbaatar and colleagues (2003) examined the use of an iNOS inhibitor, BBS-2, on sheep.
Spec (examined) Negative_regulation (inhibitor) of iNOS associated with bardet-biedl syndrome
14) Confidence 0.16 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761179 Disease Relevance 1.08 Pain Relevance 0.21
In the present study, inhibition of leptin-induced endogenous NO production in OA cartilage with a selective iNOS inhibitor 1400 W also suppressed the effects of leptin on PGE2, IL-6, and IL-8 production.
Negative_regulation (inhibitor) of iNOS in cartilage associated with osteoarthritis
15) Confidence 0.16 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.49 Pain Relevance 0.37
Inhibition of NO production reduced the effects of leptin on PGE2, IL-6, and IL-8 production pointing to a mediator role of NO in these leptin-induced changes in cartilage metabolism and to a possible beneficial effect of iNOS inhibitors on OA cartilage.
Spec (possible) Negative_regulation (inhibitors) of iNOS in cartilage associated with osteoarthritis
16) Confidence 0.16 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.57 Pain Relevance 0.29
Anthocyanins were shown to be effective inhibitors of lipid peroxidation, the production of nitric oxide (NO) and inducible nitric oxide synthase (iNOS) activity in different model systems [22-24].
Negative_regulation (inhibitors) of iNOS
17) Confidence 0.11 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2438359 Disease Relevance 0.05 Pain Relevance 0.14
However, the value of K(i) for clonidine binding to NOS-I depended on tetrahydrobiopterin (BH(4)) concentration, as reported for NOS inhibition by other nitrogen heterocyclic compounds.
Negative_regulation (inhibition) of NOS associated with tetrahydrobiopterin and clonidine
18) Confidence 0.08 Published 2000 Journal Biochem. Pharmacol. Section Abstract Doc Link 10874128 Disease Relevance 0.30 Pain Relevance 0.79
Clonidine inactivated neuronal Ca(2+)-dependent NOS (NOS-I) competitively without affecting NOS-II and endothelial Ca(2+)-dependent NOS (NOS-III) activity.
Negative_regulation (inactivated) of NOS in neuronal associated with clonidine
19) Confidence 0.08 Published 2000 Journal Biochem. Pharmacol. Section Abstract Doc Link 10874128 Disease Relevance 0.30 Pain Relevance 0.73
Very similar to our finding, Jang et al. showed that bee venom inhibited mRNA level of iNOS, COX-2 and NF-?
Negative_regulation (inhibited) of iNOS
20) Confidence 0.08 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0.15 Pain Relevance 0.03

General Comments

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