INT89132

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Context Info
Confidence 0.61
First Reported 2000
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 7.34
Pain Relevance 4.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOS2) oxidoreductase activity (NOS2) nucleus (NOS2)
intracellular (NOS2) cytoplasm (NOS2)
Anatomy Link Frequency
neuronal 2
cartilage 2
plasma 1
platelet 1
NOS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 171 99.66 Very High Very High Very High
Inflammatory mediators 5 99.08 Very High Very High Very High
Migraine 18 98.56 Very High Very High Very High
Clonidine 20 98.54 Very High Very High Very High
Inflammation 55 98.04 Very High Very High Very High
aspirin 1 96.88 Very High Very High Very High
Kinase C 6 95.08 Very High Very High Very High
cINOD 10 93.76 High High
Tetrahydrobiopterin 2 93.12 High High
acular 3 81.96 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 174 99.66 Very High Very High Very High
INFLAMMATION 66 98.88 Very High Very High Very High
Headache 18 98.56 Very High Very High Very High
Glioma 7 95.32 Very High Very High Very High
Disease 13 94.84 High High
Obesity 223 93.68 High High
Edema 6 91.04 High High
Injury 40 86.56 High High
Malaria 1 84.48 Quite High
Pain 7 79.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No evidence for involvement of the human inducible nitric oxide synthase (iNOS) gene in susceptibility to typical migraine.
Regulation (involvement) of iNOS associated with migraine
1) Confidence 0.61 Published 2001 Journal Am. J. Med. Genet. Section Title Doc Link 11424980 Disease Relevance 0.87 Pain Relevance 0.69
No evidence for involvement of the human inducible nitric oxide synthase (iNOS) gene in susceptibility to typical migraine.
Regulation (involvement) of inducible nitric oxide synthase associated with migraine
2) Confidence 0.53 Published 2001 Journal Am. J. Med. Genet. Section Title Doc Link 11424980 Disease Relevance 0.87 Pain Relevance 0.69
Indomethacin, ibuprofen, sulindac sulfide, and meloxicam concentration-dependently reduced nitrite production by macrophages incubated with platelets, but did not alter LPS-induced iNOS activity or platelet uptake.
Neg (not) Regulation (alter) of iNOS in platelet
3) Confidence 0.45 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15076232 Disease Relevance 0.43 Pain Relevance 0.54
In the present study, inhibition of leptin-induced endogenous NO production in OA cartilage with a selective iNOS inhibitor 1400 W also suppressed the effects of leptin on PGE2, IL-6, and IL-8 production.
Regulation (selective) of iNOS in cartilage associated with osteoarthritis
4) Confidence 0.17 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.49 Pain Relevance 0.42
Additionally, COX inhibitors are reported to lower plasma NO levels by down regulating iNOS (Enkhbaatar et al 2003).


Regulation (regulating) of iNOS in plasma
5) Confidence 0.15 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761179 Disease Relevance 0.67 Pain Relevance 0.28
Clonidine inactivated neuronal Ca(2+)-dependent NOS (NOS-I) competitively without affecting NOS-II and endothelial Ca(2+)-dependent NOS (NOS-III) activity.
Neg (without) Regulation (affecting) of NOS in neuronal associated with clonidine
6) Confidence 0.12 Published 2000 Journal Biochem. Pharmacol. Section Abstract Doc Link 10874128 Disease Relevance 0.30 Pain Relevance 0.74
Although Vuolteenaho and colleagues showed that leptin enhanced the expression of iNOS in human OA cartilage [13], iNOS mRNA level remained unchanged in leptin-treated cells.
Neg (unchanged) Regulation (unchanged) of iNOS in cartilage associated with osteoarthritis
7) Confidence 0.12 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.33 Pain Relevance 0.38
Further investigations on the effect of leptin on the expression of inflammatory mediators indicated that the adipokine was not able to modulate the mRNA level of iNOS and IL-1.
Regulation (modulate) of iNOS associated with inflammatory mediators
8) Confidence 0.12 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.07 Pain Relevance 0.10
Clonidine inactivated neuronal Ca(2+)-dependent NOS (NOS-I) competitively without affecting NOS-II and endothelial Ca(2+)-dependent NOS (NOS-III) activity.
Neg (without) Regulation (affecting) of NOS in neuronal associated with clonidine
9) Confidence 0.09 Published 2000 Journal Biochem. Pharmacol. Section Abstract Doc Link 10874128 Disease Relevance 0.30 Pain Relevance 0.74
The promoter region of the murine gene encoding iNOS and COX-2 contains NF-?
Regulation (encoding) of iNOS
10) Confidence 0.09 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 1.00 Pain Relevance 0.37

General Comments

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