INT89137

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Context Info
Confidence 0.55
First Reported 2000
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 0.71
Pain Relevance 2.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Nefl) locomotion (Nefl)
Anatomy Link Frequency
neuronal 1
sciatic nerve 1
proximal 1
Nefl (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 14 100.00 Very High Very High Very High
Morphine 15 99.82 Very High Very High Very High
opiate 3 98.72 Very High Very High Very High
antagonist 2 98.32 Very High Very High Very High
Sciatic nerve 93 98.08 Very High Very High Very High
cerebral cortex 1 98.04 Very High Very High Very High
agonist 2 97.72 Very High Very High Very High
opioid receptor 1 96.12 Very High Very High Very High
Ventral tegmentum 2 87.84 High High
Kappa opioid receptor 2 86.56 High High
Disease Link Frequency Relevance Heat
Injury 63 93.72 High High
Targeted Disruption 10 90.36 High High
Embryonic Lethality 6 80.96 Quite High
Congenital Anomalies 1 77.92 Quite High
Opiate Addiction 1 76.60 Quite High
Ganglion Cysts 66 40.40 Quite Low
Nervous System Injury 6 36.88 Quite Low
Coronary Artery Disease 9 5.00 Very Low Very Low Very Low
Neuroblastoma 3 5.00 Very Low Very Low Very Low
Schizophrenia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The activity of the NF-68 promoter was suppressed by naloxone about 55% at 10(-5) M and 30% at 10(-7) M at 48 h, but suppressed not by morphine.
Negative_regulation (suppressed) of NF-68 promoter associated with narcan and morphine
1) Confidence 0.55 Published 2000 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 10874586 Disease Relevance 0 Pain Relevance 0.72
The activity of the NF-68 promoter was suppressed by naloxone about 55% at 10(-5) M and 30% at 10(-7) M at 48 h, but suppressed not by morphine.
Neg (not) Negative_regulation (suppressed) of NF-68 promoter associated with narcan and morphine
2) Confidence 0.55 Published 2000 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 10874586 Disease Relevance 0 Pain Relevance 0.75
In contrast, chronic morphine did not decrease NF-L in cortices of mu-, delta-, and kappa-KO mice, suggesting the involvement of the three types of opioid receptors in this effect of morphine.
Neg (not) Negative_regulation (decrease) of NF-L associated with opioid receptor and morphine
3) Confidence 0.37 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14975676 Disease Relevance 0.23 Pain Relevance 0.83
We first confirmed the downregulation of NF-L proteins (62 to 68 kDa) in both distal and proximal segments of injured nerves during the early stages of nerve axotomy (Fig. 4).
Negative_regulation (downregulation) of NF-L in proximal
4) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.13 Pain Relevance 0.04
During axon regeneration, the IF expression pattern exhibited during neuronal differentiation resumes: Vimentin is re-upregulated while the NF Light chain (NF-L), another Ndel1-interacting protein in healthy axons, is downregulated [11]–[15], [17], [27], [32].
Negative_regulation (downregulated) of NF-L in neuronal
5) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.09 Pain Relevance 0.04
Mice lacking NF-L, another binding partner for Ndel1 differentially regulated during axon regeneration, exhibit delayed axon regeneration following sciatic nerve crush [32].
Negative_regulation (lacking) of NF-L in sciatic nerve associated with sciatic nerve
6) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.26 Pain Relevance 0.10

General Comments

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