INT89142

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 2000
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 28
Total Number 31
Disease Relevance 15.36
Pain Relevance 5.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lox) oxidoreductase activity (Lox) extracellular region (Lox)
proteinaceous extracellular matrix (Lox) nucleus (Lox)
Anatomy Link Frequency
plasma 1
smooth muscle 1
PC-3 1
Uterine 1
ganglion cells 1
Lox (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 3 100.00 Very High Very High Very High
aspirin 31 99.82 Very High Very High Very High
COX2 3 99.82 Very High Very High Very High
dorsal root ganglion 94 99.74 Very High Very High Very High
qutenza 8 99.68 Very High Very High Very High
Inflammation 266 99.60 Very High Very High Very High
antagonist 29 98.78 Very High Very High Very High
cINOD 12 97.00 Very High Very High Very High
Brush evoked pain 48 96.24 Very High Very High Very High
Thermal hyperalgesia 2 95.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 13 100.00 Very High Very High Very High
Stress 106 99.78 Very High Very High Very High
Ganglion Cysts 101 99.74 Very High Very High Very High
INFLAMMATION 285 99.60 Very High Very High Very High
Infection 75 99.34 Very High Very High Very High
Wound Healing 4 99.32 Very High Very High Very High
Cardiovascular Disorder Under Development 40 99.24 Very High Very High Very High
Hypoxia 11 98.84 Very High Very High Very High
Cancer 128 98.52 Very High Very High Very High
Hypertension 140 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The type 1 vanilloid receptor (VR1) is a non-specific cation channel activated by capsaicin, lipoxygenase (LOX) products, heat and acid.
Gene_expression (products) of LOX associated with qutenza
1) Confidence 0.67 Published 2003 Journal Hear. Res. Section Abstract Doc Link 12527134 Disease Relevance 0.25 Pain Relevance 0.10
Over-expression of LOX in a rat dermal wound healing model resulted in significantly enhanced mechanical strength of the wound site, indicating increased cross-linking of the extracellular matrix[31].


Gene_expression (expression) of LOX in extracellular matrix associated with injury and wound healing
2) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 0.92 Pain Relevance 0.18
A closer look into the data set revealed that LOX was represented in the microarray set with two identifiers (“S66184_s_at” and “rc_AA875582_at”, Table 1).
Gene_expression (represented) of LOX
3) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 1.07 Pain Relevance 0.24
Relative contribution of acetylated cyclo-oxygenase (COX)-2 and 5-lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin.
Gene_expression (contribution) of LOX associated with aspirin
4) Confidence 0.55 Published 2003 Journal FASEB J. Section Title Doc Link 12709408 Disease Relevance 0.53 Pain Relevance 0.51
The acetylated COX-2 remains active, and upon cell activation, initiates the generation of 15R-HETE, a lipid substrate for 5-lipoxygenase (LOX) leading to the formation of 15-epi-LXA4 (also termed "aspirin-triggered lipoxin," or ATL).
Gene_expression (generation) of LOX associated with aspirin and htlv types i and ii
5) Confidence 0.49 Published 2003 Journal FASEB J. Section Abstract Doc Link 12709408 Disease Relevance 0.37 Pain Relevance 0.23
This study demonstrates VR1 and 5-LOX expression by inner ear ganglion cells.
Gene_expression (expression) of LOX in ganglion cells associated with ganglion cysts
6) Confidence 0.45 Published 2003 Journal Hear. Res. Section Abstract Doc Link 12527134 Disease Relevance 0.26 Pain Relevance 0.10
Subsequently, it is found that the levels of COX-2 and/or 12-LOX are frequently increased in various cancers.
Gene_expression (levels) of LOX associated with cancer
7) Confidence 0.40 Published 2004 Journal Semin. Thromb. Hemost. Section Abstract Doc Link 15034803 Disease Relevance 1.00 Pain Relevance 0.22
These targets include procarcinogenic lipoxygenases (LOXs), including 5-, 8-, and 12-LOX, and anticarcinogenic LOXs, including 15-LOX-1 and possibly 15-LOX-2.
Spec (possibly) Gene_expression (include) of LOX
8) Confidence 0.38 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11522616 Disease Relevance 0.44 Pain Relevance 0.09
Uterine mRNA expressions of matrix metalloproteinase-1 (MMP-1), which degrades collagens, and of lysyl oxidase (LO), which is necessary for the formation of intra- and inter-molecular cross-links of collagen, were examined by quantitative RT-PCR.
Spec (examined) Gene_expression (expressions) of lysyl oxidase in Uterine associated with metalloproteinase
9) Confidence 0.37 Published 2004 Journal J. Endocrinol. Section Abstract Doc Link 14765986 Disease Relevance 0.25 Pain Relevance 0.14
MCL gene expression of collagen type I, collagen type III, collagen type V, fibronectin, decorin, biglycan, lysyl oxidase, matrix metalloproteinase-2, and tissue inhibitor of matrix metalloproteinase-1, measured by real-time quantitative PCR, demonstrated differential expression in the HLU-healing groups compared with Amb-healing groups at both the 3- and 7-wk time points.
Gene_expression (expression) of lysyl oxidase in MCL associated with metalloproteinase
10) Confidence 0.37 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17699562 Disease Relevance 0.21 Pain Relevance 0.22
Furthermore, because COX-1 expression was observed mainly in small-diameter DRG neurons and LOX products activate capsaicin receptors in primary sensory neurons [9], [10], COX and LOX in the DRG may participate in thermal hyperalgesia after nerve injury.
Gene_expression (products) of LOX in nerve associated with dorsal root ganglion, nervous system injury, qutenza and thermal hyperalgesia
11) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862737 Disease Relevance 1.78 Pain Relevance 1.32
Lysyl oxidase (LO) is produced by myofibroblast cells in some tissues and can be influenced by transforming growth factor beta 1 (TGF beta 1).
Gene_expression (produced) of Lysyl oxidase in myofibroblast cells
12) Confidence 0.15 Published 2000 Journal J. Occup. Environ. Med. Section Abstract Doc Link 10874650 Disease Relevance 0.38 Pain Relevance 0.38
However, HETEs and LTs produced from LOX enzyme activity augment GSIS [45].
Gene_expression (produced) of LOX
13) Confidence 0.13 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2990202 Disease Relevance 0 Pain Relevance 0
Metabolism of non-esterified AA by COX enzymes yields PGs (prostaglandins), while LOX enzymes generate LTs (leukotrienes) and HETEs (hydroxyeicosatetraenoic acids).
Gene_expression (enzymes) of LOX
14) Confidence 0.13 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2990202 Disease Relevance 0.06 Pain Relevance 0
Red ginseng treatment was efficient in decreasing H. pylori-induced 5-LOX activities and attenuating 5-LOX expression through inactivating c-jun pathway.
Gene_expression (expression) of LOX
15) Confidence 0.07 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872224 Disease Relevance 0.56 Pain Relevance 0.18
Red ginseng extracts inhibited these increments of H. pylori-stimulated 5-LOX through inactivation of c-jun phosphorylation and redox-sensitive transcriptional activation together, finally led to reduced levels of IL-8 and 5-LOX in gastric mucosal cells (Fig. 2B).
Gene_expression (levels) of LOX
16) Confidence 0.06 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872224 Disease Relevance 0.44 Pain Relevance 0.09
All of our study described above for the first time, revealed the H. pylori infection induced significant levels of 5-LOX activity rather than its expression and documented the apparent biosynthesis of its metabolite, 5-HETE, which eventually contributes to inflammatory activities through LTB4 formation.
Gene_expression (expression) of LOX associated with inflammation and infection
17) Confidence 0.06 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872224 Disease Relevance 0.45 Pain Relevance 0.15
Using the cell-impermeable tetrazolium salt WST-1 in the presence of NADH or NADPH, but in the absence of an intermediate electron acceptor, we show that cell-surface NAD(P)H-oxidase is widely expressed on mammalian cells, being more abundant on rapidly proliferating cells than on resting neutrophils and spleen cells.
Gene_expression (expressed) of H-oxidase in spleen
18) Confidence 0.05 Published 2000 Journal Antioxid. Redox Signal. Section Abstract Doc Link 11229532 Disease Relevance 0 Pain Relevance 0.04
LXs are biosynthesized from COX-2/LOX pathways.
Gene_expression (biosynthesized) of LOX
19) Confidence 0.05 Published 2009 Journal Curr. Mol. Med. Section Abstract Doc Link 19601807 Disease Relevance 0.65 Pain Relevance 0.48
In the present study, a total blockade of the pro-oxidative effects of aldosterone on aortic segments and kidney was obtained only when the rats were treated with a mineralocorticoid receptor antagonist, spironolactone, which prevented oxidative stress increase, overexpression of NAD(P)H oxidase subunits and BP elevation.
Gene_expression (overexpression) of H oxidase in kidney associated with stress and antagonist
20) Confidence 0.04 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.61 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox