INT8915

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Context Info
Confidence 0.78
First Reported 1991
Last Reported 2010
Negated 1
Speculated 5
Reported most in Abstract
Documents 199
Total Number 204
Disease Relevance 78.58
Pain Relevance 32.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf1) extracellular region (Igf1)
Anatomy Link Frequency
plasma 15
sensory neuron 10
skeletal muscle 4
mammary gland 4
neurons 4
Igf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 511 100.00 Very High Very High Very High
Inflammation 388 100.00 Very High Very High Very High
Calcitonin gene-related peptide 96 100.00 Very High Very High Very High
Nerve growth factor 78 100.00 Very High Very High Very High
Spinal cord 61 99.84 Very High Very High Very High
Somatostatin 110 99.80 Very High Very High Very High
Clonidine 19 99.74 Very High Very High Very High
neuralgia 10 99.74 Very High Very High Very High
nociceptor 8 99.74 Very High Very High Very High
lumbar region 3 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 470 100.00 Very High Very High Very High
Fracture Healing 158 100.00 Very High Very High Very High
Targeted Disruption 69 100.00 Very High Very High Very High
Cognitive Disorder 118 99.92 Very High Very High Very High
Appetite Loss 45 99.78 Very High Very High Very High
Frailty 162 99.70 Very High Very High Very High
Urological Neuroanatomy 123 99.68 Very High Very High Very High
Cancer 775 99.62 Very High Very High Very High
Sprains And Strains 83 99.60 Very High Very High Very High
Cv Unclassified Under Development 233 99.46 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
mRNA transcripts for insulin-like growth factor I (IGF-I) and its receptor are expressed in the lumbar region of the <sp</span>an style="background-color:#FFA07A">spinal cord.
Gene_expression (expressed) of IGF-I in lumbar region associated with lumbar region and spinal cord
1) Confidence 0.78 Published 1996 Journal Brain Res. Section Abstract Doc Link 8930378 Disease Relevance 0.18 Pain Relevance 0.42
We report here that the somatostatin analogue octreotide, previously demonstrated to reduce acromegalic levels of IGF-I towards normal, decreased serum IGF-I to 70 +/- 4% (mean +/- SD) of control values and hepatic IGF-I expression to 65 +/- 10% of control values in a short-term non-acromegalic rat model.
Gene_expression (expression) of IGF-I associated with somatostatin
2) Confidence 0.78 Published 1994 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8074663 Disease Relevance 0.08 Pain Relevance 0.17
Tamoxifen reduced serum IGF-I to 74 +/- 12% of control values and hepatic IGF-I expression to 46 +/- 9% of control values in this model, but the combination of octreotide and tamoxifen reduced serum IGF-I concentration to 49 +/- 10% of control values and hepatic IGF-I gene expression to 12 +/- 9% of control values.
Gene_expression (expression) of IGF-I
3) Confidence 0.78 Published 1994 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8074663 Disease Relevance 0.07 Pain Relevance 0.16
This combination represents a novel pharmacological strategy for suppressing IGF-I gene expression that may be relevant to the design of clinical trials.
Gene_expression (expression) of IGF-I gene
4) Confidence 0.78 Published 1994 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8074663 Disease Relevance 0 Pain Relevance 0.13
We recently reported that tamoxifen, a commonly used antiestrogen antineoplastic agent, significantly suppresses IGF-I gene expression and serum IGF-I levels.
Gene_expression (expression) of IGF-I gene
5) Confidence 0.78 Published 1994 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8074663 Disease Relevance 0.09 Pain Relevance 0.18
Tamoxifen reduced serum IGF-I to 74 +/- 12% of control values and hepatic IGF-I expression to 46 +/- 9% of control values in this model, but the combination of octreotide and tamoxifen reduced serum IGF-I concentration to 49 +/- 10% of control values and hepatic IGF-I gene expression to 12 +/- 9% of control values.
Gene_expression (expression) of IGF-I gene
6) Confidence 0.78 Published 1994 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8074663 Disease Relevance 0.06 Pain Relevance 0.15
The levels of serum IGF-I and hepatic IGF-I gene expression were significantly less in animals treated with the combination of octreotide and tamoxifen than in animals treated with either agent alone (p < .01).
Gene_expression (expression) of IGF-I gene
7) Confidence 0.78 Published 1994 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8074663 Disease Relevance 0.06 Pain Relevance 0.14
There is a significant down-regulation in the expression of IGF-I and IGF-IR in the small DRG neurons of STZ rats by 59% and 71%, respectively.
Gene_expression (expression) of IGF-I in neurons
8) Confidence 0.77 Published 2002 Journal Neuroreport Section Abstract Doc Link 12352620 Disease Relevance 0.26 Pain Relevance 0.21
Preferential expression of IGF-I in small DRG neurons and down-regulation following injury.
Gene_expression (expression) of IGF-I in neurons associated with neuralgia and injury
9) Confidence 0.77 Published 2002 Journal Neuroreport Section Title Doc Link 12352620 Disease Relevance 0.28 Pain Relevance 0.50
We demonstrate that IGF-I and its receptor are preferentially expressed in small (< 25 microm diameter) DRG neurons.
Gene_expression (expressed) of IGF-I in neurons
10) Confidence 0.77 Published 2002 Journal Neuroreport Section Abstract Doc Link 12352620 Disease Relevance 0.27 Pain Relevance 0.21
In this study, we examined the expression of insulin-like growth factor I (IGF-I) and its receptor (IGF-IR) in dorsal root ganglia (DRG) neurons in two rodent models of nerve injury: sciatic nerve axotomy and streptozotocin-induced (STZ) painful diabetic neuropathy.
Spec (examined) Gene_expression (expression) of insulin-like growth factor I in dorsal root ganglia associated with painful diabetic neuropathy, nervous system injury and sciatic nerve
11) Confidence 0.77 Published 2002 Journal Neuroreport Section Abstract Doc Link 12352620 Disease Relevance 0.26 Pain Relevance 0.14
In this study, we examined the expression of insulin-like growth factor I (IGF-I) and its receptor (IGF-IR) in dorsal root ganglia (DRG) neurons in two rodent models of nerve injury: sciatic nerve axotomy and streptozotocin-induced (STZ) painful diabetic neuropathy.
Spec (examined) Gene_expression (expression) of IGF-I in dorsal root ganglia associated with painful diabetic neuropathy, nervous system injury and sciatic nerve
12) Confidence 0.77 Published 2002 Journal Neuroreport Section Abstract Doc Link 12352620 Disease Relevance 0.27 Pain Relevance 0.14
IGF-1 receptor (IGF-1R) protein expression and IGF-1 mRNA levels were assessed in rat frontal cortex (FC) and hippocampus, in FLX-treated [15 mg/kg, orally; 3 (acute) or 21 (repeated) days] male Wistar rats.
Gene_expression (expression) of IGF-1 in frontal cortex associated with urological neuroanatomy, hippocampus and fluoxetine
13) Confidence 0.77 Published 2008 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17961991 Disease Relevance 0.65 Pain Relevance 0.98
IGF-1 receptor (IGF-1R) protein expression and IGF-1 mRNA levels were assessed in rat frontal cortex (FC) and hippocampus, in FLX-treated [15 mg/kg, orally; 3 (acute) or 21 (repeated) days] male Wistar rats.
Gene_expression (expression) of IGF-1 mRNA in frontal cortex associated with urological neuroanatomy, hippocampus and fluoxetine
14) Confidence 0.77 Published 2008 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17961991 Disease Relevance 0.66 Pain Relevance 0.98
Calcitonin gene-related peptide (CGRP) increases IGF-I production in vitro and in vivo, suggesting that stimulation of sensory neurons might increase the production of IGF-I in SHR.
Gene_expression (production) of IGF-I in sensory neurons
15) Confidence 0.76 Published 2008 Journal Growth Horm. IGF Res. Section Abstract Doc Link 17693108 Disease Relevance 0.17 Pain Relevance 0.12
Calcitonin gene-related peptide (CGRP) increases IGF-I production in vitro and in vivo, suggesting that stimulation of sensory neurons might increase the production of IGF-I in SHR.
Gene_expression (production) of IGF-I in sensory neurons
16) Confidence 0.76 Published 2008 Journal Growth Horm. IGF Res. Section Abstract Doc Link 17693108 Disease Relevance 0.17 Pain Relevance 0.12
Serum IGF-1 levels were normal in 28 switch patients (84.8%) at week 0 (i.e., while on octreotide LAR) and in 30 switch patients (93.7%) at week 24 or early termination.
Gene_expression (levels) of IGF-1
17) Confidence 0.76 Published 2009 Journal Pituitary Section Body Doc Link PMC2855862 Disease Relevance 0.06 Pain Relevance 0.27
The insulin-like growth factor binding proteins (IGFBPs) are present in serum and alter the half-life of IGF-I and II in the vascular compartment.
Gene_expression (present) of IGF
18) Confidence 0.75 Published 1992 Journal Endocrinology Section Abstract Doc Link 1382964 Disease Relevance 0 Pain Relevance 0
It is evident that the expression of GH and IGF-I receptors is area-specific in the TMJ.
Gene_expression (expression) of IGF-I in TMJ associated with snapping jaw
19) Confidence 0.74 Published 2001 Journal J. Dent. Res. Section Abstract Doc Link 11706949 Disease Relevance 0.41 Pain Relevance 0.41
Calcitonin gene-related peptide (CGRP) released from sensory neurons increases the production of a neuroprotective substance insulin-like growth factor I (IGF-I), and sensory neuron stimulation contributes to a reduction of spinal cord injury (SCI) by inhibiting inflammatory responses in rats.
Gene_expression (production) of insulin-like growth factor I in sensory neuron associated with inflammatory response, frailty, spinal cord and calcitonin gene-related peptide
20) Confidence 0.74 Published 2010 Journal Transl Res Section Abstract Doc Link 20970752 Disease Relevance 0.63 Pain Relevance 0.32

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