INT89164

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Context Info
Confidence 0.60
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.53
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mgst1) endoplasmic reticulum (Mgst1) nucleus (Mgst1)
Mgst1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 2 95.76 Very High Very High Very High
Paracetamol 13 87.84 High High
agonist 15 74.56 Quite High
antagonist 1 17.64 Low Low
Potency 1 17.20 Low Low
Inflammation 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 93 98.40 Very High Very High Very High
Cancer 58 94.52 High High
Colon Cancer 9 91.40 High High
Reprotox - General 1 5 88.08 High High
Hepatotoxicity 9 87.00 High High
Skin Cancer 1 86.60 High High
Apoptosis 18 86.12 High High
Shock 7 85.44 High High
Disease 4 59.00 Quite High
Aberrant Crypt Foci 1 57.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mRNA levels of GST Ya and GST Yb1 were also markedly increased 1 day after treatment with PEITC at dosages ranging from 31.6 to 200 mg/kg.
Positive_regulation (increased) of Transcription (levels) of GST
1) Confidence 0.60 Published 2000 Journal Xenobiotica Section Abstract Doc Link 10875686 Disease Relevance 0.23 Pain Relevance 0.44
The mRNA levels of GST Ya and GST Yb1 were also markedly increased 1 day after treatment with PEITC at dosages ranging from 31.6 to 200 mg/kg.
Positive_regulation (increased) of Transcription (levels) of GST
2) Confidence 0.50 Published 2000 Journal Xenobiotica Section Abstract Doc Link 10875686 Disease Relevance 0.23 Pain Relevance 0.44
Hepatic expression of mRNA for several GST genes is significantly elevated in dwarf mice over those of wild-type mice (GSTm1, GSTm3, GSTp2, GSTa2, GSTa4; Tsuchiya et al. 2004).
Positive_regulation (elevated) of Transcription (expression) of GST
3) Confidence 0.21 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.30 Pain Relevance 0
transcription of detoxification enzymes glutathione S-transferases (GST) which are known to protect cells from
Positive_regulation (enzymes) of Transcription (transcription) of GST
4) Confidence 0.04 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528242 Disease Relevance 0.78 Pain Relevance 0.25

General Comments

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