INT89166

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Context Info
Confidence 0.72
First Reported 2000
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.00
Pain Relevance 2.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mgst1) endoplasmic reticulum (Mgst1) nucleus (Mgst1)
Anatomy Link Frequency
liver 2
Mgst1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 28 98.08 Very High Very High Very High
qutenza 2 95.76 Very High Very High Very High
Morphine 1 86.84 High High
agonist 17 74.56 Quite High
antagonist 1 17.64 Low Low
Potency 2 17.20 Low Low
Bile 11 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 93 98.40 Very High Very High Very High
Cancer 59 94.52 High High
Colon Cancer 9 91.40 High High
Targeted Disruption 52 90.00 High High
Reprotox - General 1 5 88.08 High High
Hepatotoxicity 14 87.00 High High
Skin Cancer 1 86.60 High High
Apoptosis 24 86.12 High High
Shock 7 85.44 High High
Disease 5 59.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mRNA levels of GST Ya and GST Yb1 were also markedly increased 1 day after treatment with PEITC at dosages ranging from 31.6 to 200 mg/kg.
Transcription (levels) of GST
1) Confidence 0.72 Published 2000 Journal Xenobiotica Section Abstract Doc Link 10875686 Disease Relevance 0.22 Pain Relevance 0.38
The mRNA levels of GST Ya and GST Yb1 were also markedly increased 1 day after treatment with PEITC at dosages ranging from 31.6 to 200 mg/kg.
Transcription (levels) of GST
2) Confidence 0.62 Published 2000 Journal Xenobiotica Section Abstract Doc Link 10875686 Disease Relevance 0.23 Pain Relevance 0.39
Moreover, liver Gst pi mRNA levels were significantly lower in females than males.
Transcription (levels) of Gst in liver
3) Confidence 0.43 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16611625 Disease Relevance 0.47 Pain Relevance 1.16
Hepatic expression of mRNA for several GST genes is significantly elevated in dwarf mice over those of wild-type mice (GSTm1, GSTm3, GSTp2, GSTa2, GSTa4; Tsuchiya et al. 2004).
Transcription (expression) of GST
4) Confidence 0.29 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.30 Pain Relevance 0
In a separate study, we systematically compared the mRNA expression profiles for 26 phase II h-enzymes, including GST, SUL, NAT, and UGT members, between livers of chimeric mice with RIs of 71–89% and donor livers [16].
Transcription (expression) of GST in livers
5) Confidence 0.13 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0 Pain Relevance 0.09
, we analyzed CYP1A1, GST and AhRR (AhR repressor) mRNA expression as functional markers of AhR [8-11,29].
Spec (analyzed) Transcription (expression) of GST
6) Confidence 0.09 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0 Pain Relevance 0
transcription of detoxification enzymes glutathione S-transferases (GST) which are known to protect cells from
Transcription (transcription) of GST
7) Confidence 0.05 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528242 Disease Relevance 0.78 Pain Relevance 0.25

General Comments

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