INT89167

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 2.09
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mgst1) endoplasmic reticulum (Mgst1) nucleus (Mgst1)
Mgst1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 24 99.34 Very High Very High Very High
agonist 27 46.96 Quite Low
Bile 39 5.00 Very Low Very Low Very Low
Inflammation 17 5.00 Very Low Very Low Very Low
antidepressant 13 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
Eae 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Poisoning 13 99.78 Very High Very High Very High
Apoptosis 233 99.56 Very High Very High Very High
Hepatotoxicity 18 98.92 Very High Very High Very High
Stress 12 97.12 Very High Very High Very High
Targeted Disruption 42 92.28 High High
Colon Cancer 5 87.44 High High
Breast Cancer 11 81.72 Quite High
Charcot Marie Tooth Disease 2 81.32 Quite High
Toxicity 11 75.00 Quite High
Skin Cancer 1 63.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of PEITC on the expression of hepatic glutathione S-transferases (GST) and the glutathione (GSH) conjugation has been investigated in the Sprague-Dawley rat, and it has been determined whether hepatotoxicity of acetaminophen (AA) could be inhibited through the induction of GST expression in mouse. 2.
Positive_regulation (induction) of Gene_expression (expression) of GST associated with paracetamol and hepatotoxicity
1) Confidence 0.69 Published 2000 Journal Xenobiotica Section Abstract Doc Link 10875686 Disease Relevance 0.17 Pain Relevance 0.33
There was no evidence that the absence of GSTP in null animals resulted in enhanced expression of other GST isoforms in the null mice (GST alpha, 1.48%, GST mu, 1.68% of resolved proteins) compared with the wild-type animals (GST alpha, 1.50%, GST mu, 1.40%).
Positive_regulation (enhanced) of Gene_expression (expression) of GST
2) Confidence 0.43 Published 2003 Journal Proteomics Section Abstract Doc Link 12601812 Disease Relevance 0.28 Pain Relevance 0.20
Perhaps, it is in part due to gender-dependent Gst pi expression.
Positive_regulation (dependent) of Gene_expression (expression) of Gst
3) Confidence 0.38 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16611625 Disease Relevance 0.42 Pain Relevance 1.00
Protein treatment prior to GalN intoxication caused an elevation in GST activity (3.35 ± 0.09 ?
Positive_regulation (elevation) of Gene_expression (activity) of GST associated with poisoning
4) Confidence 0.24 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1868763 Disease Relevance 0.10 Pain Relevance 0
The GST-Sox17 and GST-Smad3 fusion proteins (and GST only) were expressed in BL21 cells induced with 1 mM isopropyl ?
Positive_regulation (-) of Gene_expression (expressed) of GST
5) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.06 Pain Relevance 0
The GST-Sox17 and GST-Smad3 fusion proteins (and GST only) were expressed in BL21 cells induced with 1 mM isopropyl ?
Positive_regulation (-) of Gene_expression (expressed) of GST
6) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.06 Pain Relevance 0
The GST-Sox17 and GST-Smad3 fusion proteins (and GST only) were expressed in BL21 cells induced with 1 mM isopropyl ?
Positive_regulation (-) of Gene_expression (expressed) of GST
7) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.06 Pain Relevance 0
To test whether deoxygedunin triggers TrkB dimerization, we cotransfected GST-TrkB with HA-TrkB plasmid into HEK293 cells, and treated the cells with 0.5 µM of various gedunin derivatives for 30 min.
Positive_regulation (cotransfected) of Gene_expression (cotransfected) of GST
8) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0 Pain Relevance 0
Thus, a protective effect, rather than apoptosis was expected in mice expressing high levels of GST.
Positive_regulation (levels) of Gene_expression (expressing) of GST associated with apoptosis
9) Confidence 0.05 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.64 Pain Relevance 0
To produce a GST fusion protein of Bak (GST-Bak?
Positive_regulation (-) of Gene_expression (produce) of GST
10) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0.14 Pain Relevance 0
To produce a GST fusion protein of Bak (GST-Bak?
Positive_regulation (-) of Gene_expression (produce) of GST
11) Confidence 0.04 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0.14 Pain Relevance 0

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