INT89181

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Context Info
Confidence 0.77
First Reported 2000
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 33
Total Number 50
Disease Relevance 22.48
Pain Relevance 11.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Mc3r) plasma membrane (Mc3r) signal transducer activity (Mc3r)
Anatomy Link Frequency
immune cell 6
arcuate nucleus 3
brain 2
nucleus 2
MC3 2
Mc3r (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 381 100.00 Very High Very High Very High
antagonist 166 100.00 Very High Very High Very High
melanocortin 1 receptor 63 99.96 Very High Very High Very High
Central nervous system 183 99.68 Very High Very High Very High
Inflammation 1271 99.64 Very High Very High Very High
medulla 324 98.32 Very High Very High Very High
cytokine 257 98.32 Very High Very High Very High
chemokine 224 98.08 Very High Very High Very High
Inflammatory stimuli 84 97.84 Very High Very High Very High
Inflammatory response 90 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 890 99.84 Very High Very High Very High
INFLAMMATION 1464 99.64 Very High Very High Very High
Injury 120 99.60 Very High Very High Very High
Sprains And Strains 86 99.52 Very High Very High Very High
Urological Neuroanatomy 52 99.48 Very High Very High Very High
Overweight 18 98.78 Very High Very High Very High
Body Weight 144 97.88 Very High Very High Very High
Peritonitis 14 97.32 Very High Very High Very High
Appetite Loss 120 95.56 Very High Very High Very High
Adhesions 217 94.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MC1R and MC3R mRNA and protein were both expressed in the inflamed mesenteric tissue; however, no changes in vascular responses were observed in a mouse colony bearing an inactive MC1R.
Gene_expression (expressed) of MC3R mRNA
1) Confidence 0.77 Published 2008 Journal FASEB J Section Abstract Doc Link PMC2700033 Disease Relevance 0.55 Pain Relevance 0.23
The key findings included 1) that the coat color phenotype in the lethal yellow (A(Y)/a) mouse is due to antagonism of the melanocortin-1 receptor (MC1R) by the agouti gene product; 2) the MC3R and MC4R are expressed in CNS centers involved in energy homeostasis, and 3) the combined results of pharmacological studies showing that agouti is an antagonist of the MC4R and transgenic studies showing that inhibition or loss of the MC4R recapitulate the lethal yellow phenotype.
Gene_expression (expressed) of MC3R associated with targeted disruption, melanocortin 1 receptor and antagonist
2) Confidence 0.76 Published 2002 Journal Neuropeptides Section Abstract Doc Link 12359499 Disease Relevance 0.31 Pain Relevance 0.15
The exposure of mice to cat odour caused only minor changes in the gene expression of wild-type mice, whereas in homozygous animals a significantly increased expression of the Mc3r gene in the frontal cortex and temporal lobe, and the Pomc1 gene in the temporal lobe, mesencephalon and mesolimbic area was established.
Gene_expression (expression) of Mc3r in temporal lobe associated with urological neuroanatomy
3) Confidence 0.75 Published 2006 Journal Behav. Brain Res. Section Abstract Doc Link 16488027 Disease Relevance 0.28 Pain Relevance 0.11
While it is well established that adiposity and MC3R expression play a significant role in inflammation [36], it is possible to achieve alterations in inflammation without changes in body composition.
Gene_expression (expression) of MC3R in body associated with inflammation
4) Confidence 0.74 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 1.47 Pain Relevance 0.66
Additionally, MC3R expression is crucial in mediating the anti-inflammatory effects induced by vascular tissue injury, as MC3R KO mice exhibit increased cell emigration and adhesion and increased monocyte chemotactic protein-1(MCP-1) and keratinocyte-derived chemokine mRNA expression in response to mesenteric artery tissue injury [34].
Gene_expression (expression) of MC3R in mesenteric artery associated with chemokine, inflammation, injury and adhesions
5) Confidence 0.74 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 1.30 Pain Relevance 0.59
Furthermore, although MC3R is expressed in a number of immune cell populations, its actions have been most explored in the monocyte population because they are some of the most responsive and largest producers of inflammation in the body [41].
Gene_expression (expressed) of MC3R in immune cell associated with inflammation
6) Confidence 0.74 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 0.23 Pain Relevance 0.24
It is also possible that sensitization of the MC3R and expression, indirectly regulated by proinflammatory cytokine production acutely during and following an exercise bout, may be linked to the reductions in circulating inflammatory markers observed in other exercise studies [2].
Gene_expression (expression) of MC3R associated with inflammatory marker and cytokine
7) Confidence 0.74 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 0.29 Pain Relevance 0.31
The melanocortin receptor subtypes, MC1R, MC3R, and MC5R are found on the plasma membranes of monocytes, macrophages, CD4+ T helper cells, granulocytes, and natural killer cells where, separately, they are activated in response to stress [12, 17–19].
Gene_expression (found) of MC3R in granulocytes associated with stress and melanocortin 1 receptor
8) Confidence 0.74 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 0.33 Pain Relevance 0.42
In summary, it appears that 12 weeks of moderate-intense resistance training led to a 16-fold upregulation of MC3R gene expression in whole blood from obese postmenopausal women.
Gene_expression (expression) of MC3R gene in blood associated with obesity
9) Confidence 0.74 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 0.26 Pain Relevance 0.17
In summary, it appears that resistance training may modulate melanocortin 3 receptor expression, providing a possible mechanism for the anti-inflammatory effects of exercise training.


1.

Gene_expression (expression) of melanocortin 3 receptor associated with inflammation
10) Confidence 0.74 Published 2011 Journal Journal of Aging Research Section Abstract Doc Link PMC3022199 Disease Relevance 0.65 Pain Relevance 0.16
The purpose of this study was to determine whether resistance exercise training-induced reductions in inflammation are mediated via melanocortin 3 receptor expression in obese (BMI 32.7 ± 3.7) women (65.6 ± 2.8?
Gene_expression (expression) of melanocortin 3 receptor associated with inflammation and obesity
11) Confidence 0.74 Published 2011 Journal Journal of Aging Research Section Abstract Doc Link PMC3022199 Disease Relevance 0.39 Pain Relevance 0.11
This hypothesis would require new experiments that would form the basis of future studies; in any case, the expression of both MC3R and MC1R mRNA (although at a low level, as positivity by quantitative PCR was not confirmed by the less sensitive RT-PCR method) in the mesentery favors the possible existence of local counter-regulatory circuits that could be rapidly activated after an I/R event.
Gene_expression (expression) of MC3R in mesentery
12) Confidence 0.66 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.30 Pain Relevance 0.15
Gene deficiency in MC3R produced remarkable augmentation of the cellular responses in the mesenteric microcirculation after I/R; this was particularly consistent at the 90 min time point as shown here and as evident at other time points as well (we have tested up to 4 h postreperfusion; unpublished results).
Gene_expression (produced) of MC3R
13) Confidence 0.66 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.86 Pain Relevance 0.40
This time-dependent activation hypothesis is plausible, since migrated neutrophils and mononuclear cells seemed positive for both MC1R and MC3R, instead of stromal and other cells resident in the mesenteric microvascular bed.
Gene_expression (positive) of MC3R in mononuclear cells
14) Confidence 0.66 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.30 Pain Relevance 0.19
Such a mild hyper-reactivity was unlikely due to inherent alterations in white blood cell phenotype, as we did not detect different basal expression of PMN or monocyte markers in WT and MC3R-null circulating cells.
Gene_expression (circulating cells) of MC3R-null in white blood cell
15) Confidence 0.66 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.21 Pain Relevance 0.13
In contrast, potent regulation of mesenteric MCP-1 (CCL2) and KC (CXCL1) levels by the MC3R pathway was observed, with augmented protein and mRNA expression.
Gene_expression (expression) of MC3R
16) Confidence 0.66 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.34 Pain Relevance 0.31
In contrast to the restricted distribution of the POMC neurones, MC4R and MC3R are widely present throughout the brain, although with different patterns of distribution (Table 3).
Gene_expression (present) of MC3R in brain
17) Confidence 0.66 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.56 Pain Relevance 0.29
[121] This could explain the extensive expression of mc3r and mc4r, despite the very limited POMC axonal presence in the VMH.
Gene_expression (expression) of mc3r
18) Confidence 0.66 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.21 Pain Relevance 0.11
Thus, it is important to note that while the EX subjects in the current study tended to experience an increase in IL-10 mRNA expression and had increased expression of the MC3R, they did not experience significant alterations in body weight or composition.
Gene_expression (expression) of MC3R in body associated with body weight
19) Confidence 0.65 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 1.05 Pain Relevance 0.47
The Melanocortin 3 Receptor: A Novel Mediator of Exercise-Induced Inflammation Reduction in Postmenopausal Women?


Gene_expression (The) of Melanocortin 3 Receptor associated with inflammation
20) Confidence 0.65 Published 2011 Journal Journal of Aging Research Section Title Doc Link PMC3022199 Disease Relevance 0.54 Pain Relevance 0.13

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