INT892

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Context Info
Confidence 0.60
First Reported 1978
Last Reported 2009
Negated 3
Speculated 2
Reported most in Abstract
Documents 23
Total Number 25
Disease Relevance 8.46
Pain Relevance 8.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TRH) extracellular region (TRH) plasma membrane (TRH)
nucleus (TRH) cell-cell signaling (TRH) cytoplasm (TRH)
Anatomy Link Frequency
plasma 1
thyrotrophs 1
neurons 1
pituitary 1
basal ganglia 1
TRH (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 30 100.00 Very High Very High Very High
Somatostatin 10 100.00 Very High Very High Very High
substance P 9 100.00 Very High Very High Very High
Clonidine 5 100.00 Very High Very High Very High
Enkephalin 5 100.00 Very High Very High Very High
Serotonin 6 99.98 Very High Very High Very High
Cholecystokinin 6 99.22 Very High Very High Very High
headache 7 98.84 Very High Very High Very High
butorphanol 5 98.84 Very High Very High Very High
Endogenous opioid 15 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Panic Disorder 10 99.84 Very High Very High Very High
Starvation 3 99.68 Very High Very High Very High
Epilepsy 5 99.28 Very High Very High Very High
Convulsion 5 98.96 Very High Very High Very High
Cluster Headache 6 98.84 Very High Very High Very High
Stress 4 98.84 Very High Very High Very High
Cancer 3 97.56 Very High Very High Very High
Disease 13 97.52 Very High Very High Very High
Hypoglycemia 1 96.96 Very High Very High Very High
Thyroid Disease 10 96.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Derangements in TRH regulation may lower thresholds for seizure expression by regulating arousal systems; however, some TRH analogs have proven to be effective anticonvulsants.
Regulation (regulation) of TRH associated with convulsion and anticonvulsant
1) Confidence 0.60 Published 1986 Journal Adv Neurol Section Abstract Doc Link 2871723 Disease Relevance 0.97 Pain Relevance 0.65
The TSH response to TRH was undetectable on three occasions.
Regulation (response) of TRH
2) Confidence 0.44 Published 1978 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 109456 Disease Relevance 0.66 Pain Relevance 0.07
In a second study indoprofen (400 mg, i.v., three times daily for 7 days) did not modify the PRL response to thyrotropin-releasing hormone nor serum GH levels.
Regulation (response) of thyrotropin-releasing hormone
3) Confidence 0.44 Published 1983 Journal Int J Clin Pharmacol Ther Toxicol Section Abstract Doc Link 6354944 Disease Relevance 0.32 Pain Relevance 0.83
Serotonin modulates the levels of mRNAS coding for thyrotropin-releasing hormone and preprotachykinin by different mechanisms in medullary raphe neurons.
Regulation (modulates) of thyrotropin-releasing hormone in neurons associated with raphe and serotonin
4) Confidence 0.44 Published 1993 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 8389958 Disease Relevance 0 Pain Relevance 0.58
In order to gain insight into the neuroendocrine mechanism underlying the paradoxical GH response to TRH in acromegalic patients, we have investigated the effect of an infusion of Naloxone (Nal, 1.6 mg/hr for two hours), on a TRH test performed both in responder (n = 9) and non-responder (n = 5) acromegalic patients.
Spec (investigated) Regulation (effect) of TRH associated with narcan
5) Confidence 0.44 Published 1996 Journal Exp. Clin. Endocrinol. Diabetes Section Abstract Doc Link 8750573 Disease Relevance 0 Pain Relevance 0.19
The PRL response to TRH was blunted in 4 of 6 patients with normalized basal PRL.
Regulation (response) of TRH
6) Confidence 0.44 Published 1990 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2394774 Disease Relevance 0.60 Pain Relevance 0.14
The present results do not support the hypothesis that the blunted TSH response to TRH observed in depressed patients results from a deficiency in noradrenergic neurotransmission.
Regulation (response) of TRH
7) Confidence 0.44 Published 1991 Journal Neurochem. Res. Section Abstract Doc Link 1754034 Disease Relevance 0 Pain Relevance 0.28
We observed a normal dexamethasone suppression test (DST) in all patients, increased cortisol plasma levels in remission patients at 8.00am before and at the end of the DST, while only in CH patients during cluster period did we find a reduced TSH response to TRH and a reduced night-time melatonin peak.
Regulation (response) of TRH in plasma associated with headache and dexamethasone
8) Confidence 0.44 Published 1992 Journal Ital J Neurol Sci Section Abstract Doc Link 1624279 Disease Relevance 0.42 Pain Relevance 0.64
The basal level of TSH and its response to TRH injection was normalized in the patients with subclinically toxic nodule.
Regulation (response) of TRH in nodule
9) Confidence 0.44 Published 1996 Journal Ann Nucl Med Section Abstract Doc Link 8800445 Disease Relevance 0.46 Pain Relevance 0.07
The effects of motilin, neurotensin, and thyrotropin-releasing hormone were greatly reduced or abolished by perfusion of the preparation with tetrodotoxin.
Regulation (effects) of thyrotropin-releasing hormone associated with tetrodotoxin
10) Confidence 0.44 Published 1979 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 115560 Disease Relevance 0 Pain Relevance 0.54
In these studies, we examined the effect of peripherally administered putative satiety substances, cholecystokininoctapeptide, somatostatin, bombesin, gastrin-releasing peptide, thyrotropin-releasing hormone, calcitonin and glucagon on butorphanol induced feeding.
Spec (examined) Regulation (effect) of thyrotropin-releasing hormone associated with butorphanol and somatostatin
11) Confidence 0.44 Published 1983 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 6316370 Disease Relevance 0.08 Pain Relevance 0.80
However, significant GH responses to TRH or hpGRF were observed when the interval between injections was either 120 or 240 min.
Regulation (responses) of TRH
12) Confidence 0.43 Published 1985 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 3926599 Disease Relevance 0 Pain Relevance 0
The effect of naloxone on PRL and TSH response to TRH was studied in 8 normal men.
Regulation (response) of TRH associated with narcan
13) Confidence 0.42 Published 1989 Journal Minerva Endocrinol. Section Abstract Doc Link 2503692 Disease Relevance 0 Pain Relevance 0.42
PRL response to TRH was unaffected by the administration of naloxone.
Neg (unaffected) Regulation (unaffected) of TRH associated with narcan
14) Confidence 0.42 Published 1989 Journal Minerva Endocrinol. Section Abstract Doc Link 2503692 Disease Relevance 0 Pain Relevance 0.44
In conclusion, cortisol suppressed basal TSH and PRL secretion and reduced the sensitivity of the thyrotrophs to TRH, without affecting the PRL response to TRH.
Neg (without) Regulation (affecting) of TRH in thyrotrophs
15) Confidence 0.41 Published 1999 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 10323386 Disease Relevance 0.07 Pain Relevance 0.41
The PRL responses to TRH were similar during hypo- and normocortisolism and without any change during opioid receptor blockade.
Regulation (responses) of TRH associated with opioid receptor
16) Confidence 0.41 Published 1999 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 10323386 Disease Relevance 0.07 Pain Relevance 0.47
Effects of pyridostigmine and naloxone on the abnormal TSH response to TRH during starvation in humans.
Regulation (response) of TRH associated with starvation and narcan
17) Confidence 0.31 Published 1999 Journal J. Investig. Med. Section Title Doc Link 10361382 Disease Relevance 0.20 Pain Relevance 0.23
Presence of normal serum PRL levels, normal PRL response to TRH and reduced GH responses to pituitary and hypothalamic stimuli suggests both hypothalamic and pituitary damage.
Regulation (response) of TRH in pituitary
18) Confidence 0.28 Published 1996 Journal J. Endocrinol. Invest. Section Abstract Doc Link 8796342 Disease Relevance 0.81 Pain Relevance 0.14
No thyrotropin releasing hormone or enkephalin immunoreactivity was seen in skin from either the patients or the controls.
Neg (No) Regulation (immunoreactivity) of thyrotropin releasing hormone in skin associated with enkephalin
19) Confidence 0.26 Published 1984 Journal Virchows Arch., B, Cell Pathol. Section Abstract Doc Link 6206641 Disease Relevance 0.15 Pain Relevance 0.22
TSH response was absent after TRH and domperidone, while TSH serum levels decreased by 25% after bromocriptine.
Regulation (response) of TRH
20) Confidence 0.26 Published 1989 Journal J. Endocrinol. Invest. Section Abstract Doc Link 2592743 Disease Relevance 0.32 Pain Relevance 0.10

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