INT89209

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Context Info
Confidence 0.06
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.70
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs1) nuclear envelope (Ptgs1) oxidoreductase activity (Ptgs1)
Golgi apparatus (Ptgs1) endoplasmic reticulum (Ptgs1) plasma membrane (Ptgs1)
Anatomy Link Frequency
poly 2
Ptgs1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 18 99.72 Very High Very High Very High
Inflammatory mediators 5 97.36 Very High Very High Very High
Inflammation 14 96.76 Very High Very High Very High
Pyramidal cell 1 94.44 High High
adenocard 5 93.60 High High
COX-2 inhibitor 1 83.04 Quite High
COX2 3 25.00 Low Low
cOX1 1 25.00 Low Low
cerebral cortex 1 9.44 Low Low
cytokine 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 28 99.44 Very High Very High Very High
Pressure And Volume Under Development 20 99.04 Very High Very High Very High
Colon Cancer 1 98.84 Very High Very High Very High
Cancer 6 96.08 Very High Very High Very High
Neurodegenerative Disease 11 95.92 Very High Very High Very High
Wound Healing 22 95.88 Very High Very High Very High
Familial Adenomatous Polyposis 3 90.32 High High
Thymoma 2 87.52 High High
Adenoma 5 79.60 Quite High
Apoptosis 6 78.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND: Most nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit both cyclooxygenase-1 (COX-1), whose inhibition is associated with gastrointestinal ulceration, and COX-2, whose inhibition is associated with therapeutic benefits.
Negative_regulation (inhibit) of cyclooxygenase-1 Binding (associated) of associated with inflammation and cinod
1) Confidence 0.06 Published 2000 Journal Ann. Intern. Med. Section Abstract Doc Link 10877734 Disease Relevance 0.10 Pain Relevance 0.20
BACKGROUND: Most nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit both cyclooxygenase-1 (COX-1), whose inhibition is associated with gastrointestinal ulceration, and COX-2, whose inhibition is associated with therapeutic benefits.
Negative_regulation (inhibit) of cyclooxygenase-1 Binding (associated) of associated with inflammation and cinod
2) Confidence 0.06 Published 2000 Journal Ann. Intern. Med. Section Abstract Doc Link 10877734 Disease Relevance 0.10 Pain Relevance 0.20
Treatment with the nonselective cyclooxygenase (COX) inhibitor carprofen prevents poly(I ? 
Negative_regulation (prevents) of cyclooxygenase Binding (Treatment) of in poly
3) Confidence 0.05 Published 2010 Journal mBio Section Body Doc Link PMC2953007 Disease Relevance 0.47 Pain Relevance 0.23
The selective inhibitors of phospholipase A2, 4-bromophenacyl bromide (300 µM), and of cyclooxygenase, indomethacin (10 µM), prevented the swelling of Müller cells from Dp71-null mice (Fig. 5C; 103.3±2.1%, n?
Negative_regulation (inhibitors) of cyclooxygenase Binding (indomethacin) of associated with pressure and volume under development
4) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.82 Pain Relevance 0.30
COX: cyclooxygenase; CYP: cytochrome P450; IOD: integrated optical density; GC-MS: gas chromatography-mass spectrometry; LOX: lipoxygenase; MUFA: monounsaturated fatty acid; MVD: Micro vessel density; PUFA: polyunsaturated fatty acid; ROS: reactive oxygen species; RT-PCR: reverse transcriptase polymerase chain reaction; VEGFA: vascular endothelial growth factor A; AKT1: v-akt murine thymoma viral oncogene homolog 1.


Negative_regulation (density) of cyclooxygenase Binding (cytochrome P450) of associated with thymoma
5) Confidence 0.02 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2841600 Disease Relevance 0.58 Pain Relevance 0
NSAIDs nonselectively inhibit both the constitutive cyclooxygenase (COX) 1 associated with side effects and the desired therapeutic target COX-2, which is induced in inflammation and neoplasia.
Negative_regulation (inhibit) of constitutive cyclooxygenase Binding (associated) of associated with inflammation, cancer and cinod
6) Confidence 0.02 Published 2000 Journal Cancer Res. Section Abstract Doc Link 11016626 Disease Relevance 0.63 Pain Relevance 0.46

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