INT8921

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Context Info
Confidence 0.36
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.18
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpc4) protein complex (Trpc4) transmembrane transport (Trpc4)
cytoplasm (Trpc4)
Anatomy Link Frequency
plasma 1
Trpc4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 3 90.48 High High
amygdala 4 85.36 High High
Substantia nigra 4 83.92 Quite High
Action potential 3 78.20 Quite High
Hippocampus 24 67.04 Quite High
Pyramidal cell 11 53.72 Quite High
Neuronal excitability 1 51.52 Quite High
Calcium channel 4 42.00 Quite Low
tetrodotoxin 10 36.12 Quite Low
sodium channel 2 33.84 Quite Low
Disease Link Frequency Relevance Heat
Hypertrophy 1 91.00 High High
Vibrio Infection 1 84.56 Quite High
Depression 1 28.40 Quite Low
Urological Neuroanatomy 6 5.00 Very Low Very Low Very Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The blockade of the sADP by the TRPC channel blocker, SKF96395 and the ability of the TRPC4 and 5 potentiator, La 3+ to induce the sADP in the absence of any group 1 mGluR simulation provides evidence for TRPC4 and 5 involvement in mediating the sADP.
Negative_regulation (blockade) of TRPC4
1) Confidence 0.36 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.20
Second, the single-cell RT-PCR investigation demonstrated that mRNAs for many TRPC subunits are present in hcrt/orx cells and that for at least two of them, TRPC4 and 5, they are present in the vast majority (?
Negative_regulation (present) of TRPC4
2) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3002943 Disease Relevance 0 Pain Relevance 0.08
Nifedipine-induced blockade of the plasma membrane L-type calcium entry channel prevented induction of skeletal alpha-actin mRNA by isoproterenol.
Negative_regulation (blockade) of calcium entry channel in plasma
3) Confidence 0.07 Published 1992 Journal J. Biol. Chem. Section Abstract Doc Link 1383212 Disease Relevance 0.18 Pain Relevance 0.05

General Comments

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