INT89229

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Context Info
Confidence 0.06
First Reported 2000
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.10
Pain Relevance 2.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nqo1) oxidoreductase activity (Nqo1) aging (Nqo1)
cytoplasm (Nqo1)
Anatomy Link Frequency
lateral hypothalamic area 2
respiratory 2
Nqo1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Versed 10 99.92 Very High Very High Very High
amygdala 7 99.76 Very High Very High Very High
qutenza 10 97.96 Very High Very High Very High
Morphine 13 97.84 Very High Very High Very High
tail-flick 1 92.24 High High
tolerance 8 84.84 Quite High
intrathecal 1 78.40 Quite High
Neurotransmitter 1 77.44 Quite High
analgesia 3 76.72 Quite High
addiction 1 65.96 Quite High
Disease Link Frequency Relevance Heat
Nociception 1 95.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of nicotinamide adenine dinucleotide phosphate diaphorase, a histochemical marker for NOS, was also increased in these brain areas in addition to the periventricular and lateral hypothalamic area and central amygdaloid nucleus.
Positive_regulation (increased) of Gene_expression (expression) of diaphorase in lateral hypothalamic area
1) Confidence 0.06 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10880996 Disease Relevance 0 Pain Relevance 0.81
The activities of the NADH:ubiquinone-1 and NADH:menadione oxidoreductase were very resistant to such respiratory chain inhibitors as rotenone, capsaicin, and AgNO(3), whereas these activities were sensitive to 2-heptyl-4-hydroxyquinoline-N-oxide (HQNO).
Positive_regulation (activities) of Gene_expression (resistant) of menadione oxidoreductase in respiratory associated with qutenza
2) Confidence 0.01 Published 2007 Journal J. Biochem. Mol. Biol. Section Abstract Doc Link 17244482 Disease Relevance 0 Pain Relevance 0.10
Immunocytochemistry, histochemistry and western blot were performed to determine the effect of midazolam on formalin-induced expression of Fos protein, nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) and nitric oxide synthase (NOS) in chronic morphine-tolerant rats, respectively.
Spec (determine) Positive_regulation (formalin-induced) of Gene_expression (expression) of phosphate-diaphorase associated with versed and morphine
3) Confidence 0.01 Published 2005 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15740792 Disease Relevance 0.10 Pain Relevance 1.90

General Comments

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