INT89233

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Context Info
Confidence 0.77
First Reported 2000
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 21
Total Number 32
Disease Relevance 9.20
Pain Relevance 4.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Abcc1) transmembrane transport (Abcc1) cytoplasm (Abcc1)
oxidoreductase activity (Abcc1) nucleolus (Abcc1) nucleus (Abcc1)
Anatomy Link Frequency
placenta 6
SK-MEL-3 4
liver 3
plasma 1
erythrocytes 1
Abcc1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
induced neuropathy 6 99.80 Very High Very High Very High
vincristine 21 99.58 Very High Very High Very High
tetrodotoxin 2 96.28 Very High Very High Very High
Morphine 11 95.68 Very High Very High Very High
addiction 8 93.04 High High
Dopamine 9 92.80 High High
Paracetamol 19 90.72 High High
palliative 2 89.12 High High
Analgesic 3 87.28 High High
Neuropathic pain 3 83.92 Quite High
Disease Link Frequency Relevance Heat
Cancer 314 99.98 Very High Very High Very High
Neuropathic Pain 9 99.80 Very High Very High Very High
Targeted Disruption 2 99.62 Very High Very High Very High
Breast Cancer 1 99.40 Very High Very High Very High
Skin Cancer 128 99.12 Very High Very High Very High
Shock 80 98.88 Very High Very High Very High
Prostate Cancer 8 98.24 Very High Very High Very High
Drug Induced Neurotoxicity 6 98.20 Very High Very High Very High
Carcinoma 10 94.96 High High
Nash(non-alcoholic Steatohepatitis) 4 92.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, over-expression of MRP1 did not affect transport of the acid metabolites.
Gene_expression (over) of MRP1
1) Confidence 0.77 Published 2000 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10882041 Disease Relevance 0 Pain Relevance 0.30
In the placenta, we detected high levels of Mrp1 and Oatp4a1 expression (Figure 4A).
Gene_expression (expression) of Mrp1 in placenta
2) Confidence 0.72 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0
Quantitative RT-PCR confirmed the high levels of Mrp1 and Oatp4a1 expression in the placenta and showed that Mrp2 was highly expressed in maternal liver (Figure 4B).
Gene_expression (expression) of Mrp1 in liver
3) Confidence 0.72 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0
High expression levels of Oatp4a1 and Mrp1 in rat placenta have been also reported by Leazer and Klaassen (2003).
Gene_expression (expression) of Mrp1 in placenta
4) Confidence 0.72 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0
In the present study, we observed high expression of Oatp4a1 and Mrp1 in the placenta by quantitative RT-PCR.
Gene_expression (expression) of Mrp1 in placenta
5) Confidence 0.72 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0
First, we examined the expression of the Oatp and Mrp families in the placenta and maternal liver on GD18.5 by RT-PCR.
Spec (examined) Gene_expression (expression) of Mrp in placenta
6) Confidence 0.72 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0
With a validated rat model of VCT-induced neuropathy, (1) the expressions of mdr1a (P-gp), mdr1b (P-gp), mrp1 (MRP1), and mrp2 (MRP2) genes were assessed by quantitative real-time polymerase chain reaction, and (2) the transporter activity was monitored using a radioactive tracer, (99m)Tc-sestamibi, in the CNS and PNS.
Gene_expression (expressions) of mrp1 associated with vincristine, induced neuropathy and neuropathic pain
7) Confidence 0.70 Published 2005 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 16221289 Disease Relevance 0.33 Pain Relevance 0.46
With a validated rat model of VCT-induced neuropathy, (1) the expressions of mdr1a (P-gp), mdr1b (P-gp), mrp1 (MRP1), and mrp2 (MRP2) genes were assessed by quantitative real-time polymerase chain reaction, and (2) the transporter activity was monitored using a radioactive tracer, (99m)Tc-sestamibi, in the CNS and PNS.
Gene_expression (expressions) of MRP1 associated with vincristine, induced neuropathy and neuropathic pain
8) Confidence 0.70 Published 2005 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 16221289 Disease Relevance 0.33 Pain Relevance 0.46
Both Mrp1 and Oatp4a1 are known to transport endogenous estrogen conjugates, such as dehydroepiandrosterone-sulfate (DHEAS) and 17?
Gene_expression (known) of Mrp1
9) Confidence 0.62 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0
Some members of the Oatp and Mrp transporter families are known to transport conjugates of steroid hormones such as DHEAS and 17?
Gene_expression (families) of Mrp transporter
10) Confidence 0.62 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0
VCT treatment increased expression of the mdr1a gene in the CNS and PNS (both x1.7), mrp1 gene in the PNS (x1.7), and transporter activity in both the CNS and the PNS (x4 and x8, respectively).
Gene_expression (expression) of mrp1 gene associated with vincristine
11) Confidence 0.61 Published 2005 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 16221289 Disease Relevance 0.32 Pain Relevance 0.56
However, over-expression of MRP1 did not affect transport of the acid metabolites.
Gene_expression (expression) of MRP1
12) Confidence 0.60 Published 2000 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10882041 Disease Relevance 0 Pain Relevance 0.30
Quantitative expression of Mrp1, Mrp2, and Oatp4a1 mRNA in maternal liver and placenta was investigated by real-time RT-PCR using the QuantiTect SYBR Green PCR kit (Qiagen) and analyzed by iQ5/MyiQ Single-Color (Bio-Rad Laboratories Inc., Hercules, CA, USA).
Gene_expression (expression) of Mrp1 in placenta
13) Confidence 0.55 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0
High expression levels of Oatp4a1 and Mrp1 in rat placenta have been also reported by Leazer and Klaassen (2003).
Gene_expression (levels) of Mrp1 in placenta
14) Confidence 0.55 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0
The expression of genes Mdr1a, Mrp1, Bcrp, Glut-1 and Occludin, was slightly increased, while that of Flk-1 was decreased in microvessels from morphine-treated rats.
Gene_expression (expression) of Mrp1 associated with morphine
15) Confidence 0.39 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18761714 Disease Relevance 0 Pain Relevance 0.60
The P(app) values of TSB in the BL-AP direction were significantly higher in MDCKII cells over-expressing MDR1 or MRP1, but not in cells over-expressing MRP2-5, as compared with the wild-type cells.
Neg (not) Gene_expression (expressing) of MRP1
16) Confidence 0.37 Published 2007 Journal Xenobiotica Section Abstract Doc Link 17455112 Disease Relevance 0.10 Pain Relevance 0.08
The plasma AUC(0-24hr) in mdr1a and mrp1 gene-deficient mice was 10.2- to 1.7-fold higher than that in the wild-type mice.
Gene_expression (deficient) of mrp1 in plasma
17) Confidence 0.32 Published 2007 Journal Xenobiotica Section Abstract Doc Link 17455112 Disease Relevance 0 Pain Relevance 0.03
In the livers of MCD rats, there were striking increases in both mRNA and protein levels of multidrug resistance-associated protein (Mrp) 3, Mrp4, and breast cancer resistance protein, as well as increased Mrp2 protein.
Gene_expression (levels) of Mrp in livers associated with breast cancer
18) Confidence 0.23 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17640958 Disease Relevance 0.91 Pain Relevance 1.00
Despite high concentrations of the cytostatic drug and the exposition towards hyperthermic temperatures, only temporary effects on gene expression, that is, mrp1 (suppression) and mrp2 (induction) could be observed.
Gene_expression (suppression) of mrp1
19) Confidence 0.22 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 0.79 Pain Relevance 0
Despite high concentrations of the cytostatic drug and the exposition towards hyperthermic temperatures, only temporary effects on gene expression, that is, mrp1 (suppression) and mrp2 (induction) could be observed.
Gene_expression (expression) of mrp1
20) Confidence 0.22 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 0.79 Pain Relevance 0

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