INT89234

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Context Info
Confidence 0.50
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 3.56
Pain Relevance 2.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Abcc1) transmembrane transport (Abcc1) cytoplasm (Abcc1)
oxidoreductase activity (Abcc1) nucleolus (Abcc1) nucleus (Abcc1)
Anatomy Link Frequency
erythrocytes 2
livers 2
placenta 2
Abcc1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
vincristine 7 99.78 Very High Very High Very High
Morphine 11 97.72 Very High Very High Very High
tetrodotoxin 1 96.28 Very High Very High Very High
addiction 6 93.04 High High
Dopamine 4 92.80 High High
Paracetamol 15 92.12 High High
palliative 1 89.12 High High
Analgesic 1 87.28 High High
Hippocampus 2 85.04 High High
Neuropathic pain 1 83.92 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 2 99.62 Very High Very High Very High
Breast Cancer 1 99.40 Very High Very High Very High
Drug Induced Neurotoxicity 2 98.60 Very High Very High Very High
Prostate Cancer 4 98.24 Very High Very High Very High
Carcinoma 3 94.96 High High
Nash(non-alcoholic Steatohepatitis) 4 94.04 High High
Fatty Liver 6 93.68 High High
Skin Cancer 32 88.80 High High
Cancer 79 83.00 Quite High
Osteogenic Sarcomas 2 79.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, over-expression of MRP1 did not affect transport of the acid metabolites.
Positive_regulation (over-expression) of Gene_expression (over) of MRP1
1) Confidence 0.50 Published 2000 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10882041 Disease Relevance 0 Pain Relevance 0.30
In the placenta, we detected high levels of Mrp1 and Oatp4a1 expression (Figure 4A).
Positive_regulation (levels) of Gene_expression (expression) of Mrp1 in placenta
2) Confidence 0.46 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0
VCT treatment increased expression of the mdr1a gene in the CNS and PNS (both x1.7), mrp1 gene in the PNS (x1.7), and transporter activity in both the CNS and the PNS (x4 and x8, respectively).
Positive_regulation (increased) of Gene_expression (expression) of mrp1 gene associated with vincristine
3) Confidence 0.45 Published 2005 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 16221289 Disease Relevance 0.32 Pain Relevance 0.57
The expression of genes Mdr1a, Mrp1, Bcrp, Glut-1 and Occludin, was slightly increased, while that of Flk-1 was decreased in microvessels from morphine-treated rats.
Positive_regulation (increased) of Gene_expression (expression) of Mrp1 associated with morphine
4) Confidence 0.31 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18761714 Disease Relevance 0 Pain Relevance 0.62
The P(app) values of TSB in the BL-AP direction were significantly higher in MDCKII cells over-expressing MDR1 or MRP1, but not in cells over-expressing MRP2-5, as compared with the wild-type cells.
Neg (not) Positive_regulation (over-expressing) of Neg (not) Gene_expression (expressing) of MRP1
5) Confidence 0.24 Published 2007 Journal Xenobiotica Section Abstract Doc Link 17455112 Disease Relevance 0.10 Pain Relevance 0.08
In the livers of MCD rats, there were striking increases in both mRNA and protein levels of multidrug resistance-associated protein (Mrp) 3, Mrp4, and breast cancer resistance protein, as well as increased Mrp2 protein.
Positive_regulation (increases) of Gene_expression (levels) of Mrp in livers associated with breast cancer
6) Confidence 0.17 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17640958 Disease Relevance 0.93 Pain Relevance 1.00
Despite high concentrations of the cytostatic drug and the exposition towards hyperthermic temperatures, only temporary effects on gene expression, that is, mrp1 (suppression) and mrp2 (induction) could be observed.
Positive_regulation (induction) of Gene_expression (expression) of mrp1
7) Confidence 0.17 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 0.80 Pain Relevance 0
Despite high concentrations of the cytostatic drug and the exposition towards hyperthermic temperatures, only temporary effects on gene expression, that is, mrp1 (suppression) and mrp2 (induction) could be observed.
Positive_regulation (induction) of Gene_expression (suppression) of mrp1
8) Confidence 0.17 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 0.79 Pain Relevance 0
Interestingly, CFTR knockout animals, in which MRP1 expression was found to be augmented, had an increased rate of ATP release from unstimulated erythrocytes, suggesting that ATP release was mediated by MRP1 but not by CFTR.
Positive_regulation (augmented) of Gene_expression (expression) of MRP1 in erythrocytes associated with targeted disruption
9) Confidence 0.14 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096548 Disease Relevance 0.27 Pain Relevance 0
Phosphatidylinositol 3'-kinase activation leads to multidrug resistance protein-1 expression and subsequent chemoresistance in advanced prostate cancer cells.
Positive_regulation (leads) of Gene_expression (expression) of multidrug resistance protein-1 associated with prostate cancer
10) Confidence 0.04 Published 2004 Journal Cancer Res. Section Title Doc Link 15548710 Disease Relevance 0.36 Pain Relevance 0.09

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