INT89239

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Context Info
Confidence 0.39
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.11
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (VEGFC) signal transduction (VEGFC) extracellular space (VEGFC)
extracellular region (VEGFC)
Anatomy Link Frequency
joints 2
VEGFC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 1 99.90 Very High Very High Very High
chemokine 1 99.84 Very High Very High Very High
Infliximab 12 98.96 Very High Very High Very High
rheumatoid arthritis 6 95.84 Very High Very High Very High
depression 11 92.00 High High
methotrexate 5 82.24 Quite High
cva 98 78.08 Quite High
ischemia 25 48.72 Quite Low
headache 4 33.68 Quite Low
spinal-cord stimulation 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 2 99.70 Very High Very High Very High
Increased Venous Pressure Under Development 14 98.54 Very High Very High Very High
Rheumatoid Arthritis 6 95.84 Very High Very High Very High
Depression 11 92.00 High High
Necrosis 1 91.04 High High
Cancer 1 90.68 High High
Dilated Cardiomyopathy 1 84.64 Quite High
Myocardial Infarction 50 83.12 Quite High
Cv General 3 Under Development 97 78.08 Quite High
Acidosis 1 54.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Secondary to inhibition of TNFalpha, infliximab reduces serum levels of inflammatory mediators and vascular endothelial growth factor, decreases the expression of chemokines in the synovial tissue and reduces lymphocyte migration into the joints of patients with rheumatoid arthritis.
Negative_regulation (decreases) of Gene_expression (expression) of vascular endothelial growth factor in joints associated with chemokine, inflammatory mediators, infliximab and rheumatoid arthritis
1) Confidence 0.39 Published 2000 Journal Drugs Section Abstract Doc Link 10882166 Disease Relevance 0.52 Pain Relevance 0.51
Fasudil is a rho-kinase inhibitor that has been used to prevent vasospasm, especially in the pulmonary and cerebral arterial beds, in addition to inhibiting production of vascular endothelial growth factor.
Negative_regulation (inhibiting) of Gene_expression (production) of vascular endothelial growth factor associated with increased venous pressure under development
2) Confidence 0.03 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941787 Disease Relevance 0.58 Pain Relevance 0.09

General Comments

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