INT89240
From wiki-pain
|
|
|
|
|
Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
We first used a orthotopic graft model of VEGF-C overexpressing-mammary carcinoma cells (MCF7). | |||||||||||||||
| |||||||||||||||
|
Similar results were reported with VEGF-C overexpressing MDA-MB-435 [30]. | |||||||||||||||
| |||||||||||||||
|
The expression of vascular endothelial growth factor correlated well with that of HIF-1alpha. | |||||||||||||||
| |||||||||||||||
|
Vascular endothelial growth factor expression was also examined by immunohistochemistry. | |||||||||||||||
| |||||||||||||||
|
Blood and lymphatic vessels were studied by Ulex europaeus agglutinin-1, human podoplanin, human vascular endothelial growth factor-C (H-VEGF-C) and alpha-actin immunoreactivities. | |||||||||||||||
| |||||||||||||||
|
Although VEGF-C expression led to an enhancement of lymphatic vessel numbers, no difference was observed in PAI-1 WT and PAI-1? | |||||||||||||||
| |||||||||||||||
|
To test the impact of PAI-1 on lymphatic vessel recruitment in tumors, VEGF-C-overexpressing MCF7 cells or control MCF7 cells were bilaterally injected into the fifth mammary fat pads (mfp) of immunodeficient RAG-1? | |||||||||||||||
| |||||||||||||||
|
Interestingly, PAI-1 deficiency reduced the incidence of tumors developed both in the presence of VEGF-C expression (52% of VEGF-C expressing tumors in PAI-1 WT mice versus 22% in PAI-1? | |||||||||||||||
| |||||||||||||||
|
In accordance to previous report [23], VEGF-C over-expressing tumors displayed a higher relative vasculature area than control tumors. | |||||||||||||||
| |||||||||||||||
|
We checked the production of VEGF-C by the tumor cells in culture by RT-PCR (Fig. 1A) and in supernatants by ELISA (data not shown). | |||||||||||||||
| |||||||||||||||
|
In the present study, MCF7 cells overexpressing or not VEGF-C were inoculated into RAG-1? | |||||||||||||||
| |||||||||||||||
|
To test the impact of PAI-1 on lymphatic vessel recruitment in tumors, VEGF-C-overexpressing MCF7 cells or control MCF7 cells were bilaterally injected into the fifth mammary fat pads (mfp) of immunodeficient RAG-1? | |||||||||||||||
| |||||||||||||||
|
Interestingly, PAI-1 deficiency reduced the incidence of tumors developed both in the presence of VEGF-C expression (52% of VEGF-C expressing tumors in PAI-1 WT mice versus 22% in PAI-1? | |||||||||||||||
| |||||||||||||||
|
Interestingly, PAI-1 deficiency reduced the incidence of tumors developed both in the presence of VEGF-C expression (52% of VEGF-C expressing tumors in PAI-1 WT mice versus 22% in PAI-1? | |||||||||||||||
| |||||||||||||||
|
Secondary to inhibition of TNFalpha, infliximab reduces serum levels of inflammatory mediators and vascular endothelial growth factor, decreases the expression of chemokines in the synovial tissue and reduces lymphocyte migration into the joints of patients with rheumatoid arthritis. | |||||||||||||||
| |||||||||||||||
|
Statistically significant differences in protein expression involving the leucocyte extravasation, vascular endothelial growth factor, integrin and Toll-like receptor signalling pathways were seen in AS and RA monocytes compared to healthy controls. | |||||||||||||||
| |||||||||||||||
|
Liu and colleagues (2000) reported suppressing vascular endothelial growth factor and inducing apoptosis in nude mouse xenografts of the human PC cell line (PC3) with three intraperitoneal injection of the COX-2 inhibitor NS398 (3 mg/kg) over 9 week. | |||||||||||||||
| |||||||||||||||
|
Blood and lymphatic vessels were studied by Ulex europaeus agglutinin-1, human podoplanin, human vascular endothelial growth factor-C (H-VEGF-C) and alpha-actin immunoreactivities. | |||||||||||||||
| |||||||||||||||
|
In our laboratory, we more recently found that bronchial ASM cells are capable of expressing and releasing vascular endothelial growth factor, an angiogenic peptide, following stimulation with TNF-? | |||||||||||||||
| |||||||||||||||
|
Increased levels of COX-2 expression and PGE2 have also been shown to induce cell proliferation as well as angiogenesis by increasing the production of vascular-endothelial growth factor by epithelial cells [34]. | |||||||||||||||
| |||||||||||||||
|
General Comments
This test has worked.