INT89240

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 15.94
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (VEGFC) signal transduction (VEGFC) extracellular space (VEGFC)
extracellular region (VEGFC)
Anatomy Link Frequency
lymphatic vessels 2
MCF7 2
fat pads 2
macrophages 1
fibroblast 1
VEGFC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 12 99.90 Very High Very High Very High
chemokine 35 99.84 Very High Very High Very High
Infliximab 12 98.96 Very High Very High Very High
COX2 53 96.68 Very High Very High Very High
rheumatoid arthritis 95 95.84 Very High Very High Very High
COX-2 inhibitor 10 95.00 High High
Inflammation 328 94.28 High High
Potency 2 94.16 High High
depression 11 92.00 High High
Bioavailability 2 91.40 High High
Disease Link Frequency Relevance Heat
Adhesions 27 100.00 Very High Very High Very High
Cancer 677 99.96 Very High Very High Very High
INFLAMMATION 363 99.70 Very High Very High Very High
Carcinoma 23 99.64 Very High Very High Very High
Apoptosis 52 99.44 Very High Very High Very High
Increased Venous Pressure Under Development 15 98.32 Very High Very High Very High
Conjunctiva Disease 44 98.00 Very High Very High Very High
Reprotox - General 1 55 97.52 Very High Very High Very High
Metastasis 90 97.24 Very High Very High Very High
Breast Cancer 55 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We first used a orthotopic graft model of VEGF-C overexpressing-mammary carcinoma cells (MCF7).
Gene_expression (overexpressing) of VEGF-C in MCF7 associated with carcinoma
1) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2836381 Disease Relevance 1.00 Pain Relevance 0.09
Similar results were reported with VEGF-C overexpressing MDA-MB-435 [30].
Gene_expression (overexpressing) of VEGF-C
2) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2836381 Disease Relevance 1.03 Pain Relevance 0.08
The expression of vascular endothelial growth factor correlated well with that of HIF-1alpha.
Gene_expression (expression) of vascular endothelial growth factor
3) Confidence 0.73 Published 2003 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 12925145 Disease Relevance 0.21 Pain Relevance 0
Vascular endothelial growth factor expression was also examined by immunohistochemistry.
Spec (examined) Gene_expression (expression) of Vascular endothelial growth factor
4) Confidence 0.73 Published 2003 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 12925145 Disease Relevance 0.25 Pain Relevance 0
Blood and lymphatic vessels were studied by Ulex europaeus agglutinin-1, human podoplanin, human vascular endothelial growth factor-C (H-VEGF-C) and alpha-actin immunoreactivities.
Gene_expression (studied) of vascular endothelial growth factor-C in lymphatic vessels
5) Confidence 0.65 Published 2009 Journal J. Cutan. Pathol. Section Body Doc Link 18564281 Disease Relevance 0 Pain Relevance 0
Although VEGF-C expression led to an enhancement of lymphatic vessel numbers, no difference was observed in PAI-1 WT and PAI-1?
Gene_expression (expression) of VEGF-C in lymphatic vessel
6) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2836381 Disease Relevance 0.77 Pain Relevance 0
To test the impact of PAI-1 on lymphatic vessel recruitment in tumors, VEGF-C-overexpressing MCF7 cells or control MCF7 cells were bilaterally injected into the fifth mammary fat pads (mfp) of immunodeficient RAG-1?
Gene_expression (-) of VEGF-C in fat pads associated with cancer
7) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2836381 Disease Relevance 0.28 Pain Relevance 0
Interestingly, PAI-1 deficiency reduced the incidence of tumors developed both in the presence of VEGF-C expression (52% of VEGF-C expressing tumors in PAI-1 WT mice versus 22% in PAI-1?
Gene_expression (expression) of VEGF-C associated with cancer
8) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2836381 Disease Relevance 0.74 Pain Relevance 0
In accordance to previous report [23], VEGF-C over-expressing tumors displayed a higher relative vasculature area than control tumors.
Gene_expression (expressing) of VEGF-C in vasculature associated with cancer
9) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2836381 Disease Relevance 0.88 Pain Relevance 0
We checked the production of VEGF-C by the tumor cells in culture by RT-PCR (Fig. 1A) and in supernatants by ELISA (data not shown).
Gene_expression (production) of VEGF-C associated with cancer
10) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2836381 Disease Relevance 0.40 Pain Relevance 0
In the present study, MCF7 cells overexpressing or not VEGF-C were inoculated into RAG-1?
Gene_expression (overexpressing) of VEGF-C in MCF7
11) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2836381 Disease Relevance 0.97 Pain Relevance 0.07
To test the impact of PAI-1 on lymphatic vessel recruitment in tumors, VEGF-C-overexpressing MCF7 cells or control MCF7 cells were bilaterally injected into the fifth mammary fat pads (mfp) of immunodeficient RAG-1?
Gene_expression (overexpressing) of VEGF-C in fat pads associated with cancer
12) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2836381 Disease Relevance 0.28 Pain Relevance 0
Interestingly, PAI-1 deficiency reduced the incidence of tumors developed both in the presence of VEGF-C expression (52% of VEGF-C expressing tumors in PAI-1 WT mice versus 22% in PAI-1?
Gene_expression (expression) of VEGF-C associated with cancer
13) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2836381 Disease Relevance 0.74 Pain Relevance 0
Interestingly, PAI-1 deficiency reduced the incidence of tumors developed both in the presence of VEGF-C expression (52% of VEGF-C expressing tumors in PAI-1 WT mice versus 22% in PAI-1?
Gene_expression (expressing) of VEGF-C associated with cancer
14) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2836381 Disease Relevance 0.79 Pain Relevance 0
Secondary to inhibition of TNFalpha, infliximab reduces serum levels of inflammatory mediators and vascular endothelial growth factor, decreases the expression of chemokines in the synovial tissue and reduces lymphocyte migration into the joints of patients with rheumatoid arthritis.
Gene_expression (expression) of vascular endothelial growth factor in joints associated with chemokine, inflammatory mediators, infliximab and rheumatoid arthritis
15) Confidence 0.54 Published 2000 Journal Drugs Section Abstract Doc Link 10882166 Disease Relevance 0.52 Pain Relevance 0.51
Statistically significant differences in protein expression involving the leucocyte extravasation, vascular endothelial growth factor, integrin and Toll-like receptor signalling pathways were seen in AS and RA monocytes compared to healthy controls.
Gene_expression (expression) of vascular endothelial growth factor in leucocyte
16) Confidence 0.38 Published 2009 Journal Ann. Rheum. Dis. Section Body Doc Link 18952638 Disease Relevance 0.20 Pain Relevance 0
Liu and colleagues (2000) reported suppressing vascular endothelial growth factor and inducing apoptosis in nude mouse xenografts of the human PC cell line (PC3) with three intraperitoneal injection of the COX-2 inhibitor NS398 (3 mg/kg) over 9 week.
Gene_expression (suppressing) of vascular endothelial growth factor associated with cox-2 inhibitor, apoptosis and reprotox - general 1
17) Confidence 0.24 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727910 Disease Relevance 1.98 Pain Relevance 0.08
Blood and lymphatic vessels were studied by Ulex europaeus agglutinin-1, human podoplanin, human vascular endothelial growth factor-C (H-VEGF-C) and alpha-actin immunoreactivities.
Gene_expression (studied) of vascular endothelial growth factor-C in Blood
18) Confidence 0.22 Published 2009 Journal J. Cutan. Pathol. Section Body Doc Link 18564281 Disease Relevance 0 Pain Relevance 0
In our laboratory, we more recently found that bronchial ASM cells are capable of expressing and releasing vascular endothelial growth factor, an angiogenic peptide, following stimulation with TNF-?
Gene_expression (expressing) of vascular endothelial growth factor
19) Confidence 0.19 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 0.77 Pain Relevance 0.20
Increased levels of COX-2 expression and PGE2 have also been shown to induce cell proliferation as well as angiogenesis by increasing the production of vascular-endothelial growth factor by epithelial cells [34].
Gene_expression (production) of vascular-endothelial growth factor in PGE2
20) Confidence 0.13 Published 2010 Journal International Journal of Otolaryngology Section Body Doc Link PMC2902018 Disease Relevance 0.56 Pain Relevance 0.10

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