INT89247

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Context Info
Confidence 0.72
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 9
Disease Relevance 3.38
Pain Relevance 5.61

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signal transduction (Galr1) plasma membrane (Galr1) signal transducer activity (Galr1)
Anatomy Link Frequency
locus coeruleus 2
arcuate nucleus 1
hippocampus 1
Galr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Locus ceruleus 31 99.48 Very High Very High Very High
Hippocampus 66 99.08 Very High Very High Very High
Morphine 12 98.08 Very High Very High Very High
withdrawal 22 97.20 Very High Very High Very High
opiate 11 96.92 Very High Very High Very High
Neuropeptide 12 95.60 Very High Very High Very High
medulla 27 91.36 High High
analgesia 2 91.24 High High
addiction 3 90.96 High High
Neuronal excitability 15 89.84 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 38 99.42 Very High Very High Very High
Death 120 98.94 Very High Very High Very High
Convulsion 192 98.56 Very High Very High Very High
Status Epilepticus 21 98.32 Very High Very High Very High
Drug Dependence 3 91.16 High High
Sprains And Strains 41 83.36 Quite High
Obesity 57 75.80 Quite High
Toxicity 6 65.28 Quite High
Drug Induced Neurotoxicity 3 63.36 Quite High
Injury 27 63.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to test more formally the potential influence of GalR1 on seizure-induced excitotoxic cell death, we conducted functional complementation tests in which transgenic mice that exhibit decreased expression of the GalR1 candidate mRNA underwent kainate-induced status epilepticus to determine if the quantitative trait of susceptibility to seizure-induced cell death is determined by the activity of GalR1.
Transcription (expression) of GalR1 associated with targeted disruption, convulsion, status epilepticus and death
1) Confidence 0.72 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001489 Disease Relevance 0.85 Pain Relevance 0.17
The spatial differences in mRNA expression of galanin receptor subtypes in the mouse hippocampus are worth noting in light of our results.
Transcription (expression) of galanin receptor in hippocampus associated with hippocampus
2) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001489 Disease Relevance 0.91 Pain Relevance 0.26
Treatment with forskolin, but not dideoxyforskolin, up-regulates GalR1 transcription, likely through elevation of cAMP levels.
Transcription (transcription) of GalR1
3) Confidence 0.72 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11145992 Disease Relevance 0 Pain Relevance 0.55
In order to test more formally the potential influence of GalR1 on seizure-induced excitotoxic cell death, we have conducted functional complementation tests in which we determined if there are functional differences in susceptibility to seizure-induced cell death by utilizing transgenic mice that exhibit decreased expression of the GalR1 candidate mRNA.
Transcription (expression) of GalR1 associated with targeted disruption, convulsion and death
4) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001489 Disease Relevance 1.03 Pain Relevance 0.32
Moreover, the increase in galanin binding sites seems to be caused by increased transcription or stabilization of the galanin receptor 1 (GalR1) gene, because there is a dramatic increase in mRNA levels following withdrawal in the LC.
Transcription (transcription) of GalR1 associated with locus ceruleus and withdrawal
5) Confidence 0.69 Published 2000 Journal Neuropsychopharmacology Section Abstract Doc Link 10882839 Disease Relevance 0.08 Pain Relevance 1.04
Moreover, the increase in galanin binding sites seems to be caused by increased transcription or stabilization of the galanin receptor 1 (GalR1) gene, because there is a dramatic increase in mRNA levels following withdrawal in the LC.
Transcription (transcription) of galanin receptor 1 associated with locus ceruleus and withdrawal
6) Confidence 0.69 Published 2000 Journal Neuropsychopharmacology Section Abstract Doc Link 10882839 Disease Relevance 0.08 Pain Relevance 1.04
Upregulation of galanin binding sites and GalR1 mRNA levels in the mouse locus coeruleus following chronic morphine treatments and precipitated morphine withdrawal.
Transcription (levels) of GalR1 in locus coeruleus associated with locus ceruleus, withdrawal and morphine
7) Confidence 0.53 Published 2000 Journal Neuropsychopharmacology Section Title Doc Link 10882839 Disease Relevance 0.09 Pain Relevance 1.06
We have shown that opiate withdrawal, which is known to increase levels of cAMP in the locus coeruleus (LC), results in an increase in the number of galanin binding sites and the level of GalR1 mRNA in the LC.
Transcription (level) of GalR1 in locus coeruleus associated with locus ceruleus, opiate and withdrawal
8) Confidence 0.53 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11145992 Disease Relevance 0 Pain Relevance 0.65
Galanin blocks arcuate neuronal firing in those neurones expressing gal-r1 receptor mRNA, perhaps via direct contact with arcuate nucleus POMC neurones [87].


Transcription (expressing) of gal-r1 in arcuate nucleus
9) Confidence 0.04 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.35 Pain Relevance 0.52

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