INT89250

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Context Info
Confidence 0.63
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 11
Disease Relevance 3.99
Pain Relevance 2.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
uterus 3
macrophages 1
epithelium 1
locus coeruleus 1
Il11ra1 (Mus musculus)
Pain Link Frequency Relevance Heat
Locus ceruleus 7 100.00 Very High Very High Very High
Morphine 4 98.84 Very High Very High Very High
Inflammatory response 28 97.80 Very High Very High Very High
withdrawal 7 97.00 Very High Very High Very High
addiction 7 96.64 Very High Very High Very High
cytokine 122 96.40 Very High Very High Very High
Neuropeptide 8 96.36 Very High Very High Very High
Inflammation 162 96.12 Very High Very High Very High
opiate 1 84.96 Quite High
Nerve growth factor 29 77.76 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 190 97.80 Very High Very High Very High
Sprains And Strains 12 97.74 Very High Very High Very High
Targeted Disruption 38 95.64 Very High Very High Very High
Cancer 600 95.28 Very High Very High Very High
Hepatocellular Cancer 20 91.92 High High
Drug Dependence 1 91.92 High High
Inflammatory Bowel Disease 24 84.84 Quite High
Disease 20 82.72 Quite High
Wound Healing 8 80.64 Quite High
Colitis 36 79.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, in the context of gp130 mediated Stat activation, Stat1 and Stat3 are capable of regulating each other [32,33].
Positive_regulation (activation) of gp130
1) Confidence 0.63 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.29 Pain Relevance 0.15
Similarly, sustained gp130 and Stat3 activation in Socs3-deficient macrophages triggers a strong anti-inflammatory response [41-43] and expression of the canonical TGF?
Positive_regulation (activation) of gp130 in macrophages associated with inflammatory response
2) Confidence 0.63 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.86 Pain Relevance 0.36
[87,88], to activate gp130 receptors independently of the presence of the ligand-binding IL6R?
Neg (independently) Positive_regulation (activate) of gp130
3) Confidence 0.63 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.99 Pain Relevance 0.04
While the microarray data showed consistent, reproducible upregulation of COL3A1, BGN, SPARC and NID1 in IL11Ra-/- compared to wild type uterus, this effect was not statistically significant when real-time RT-PCR was used as an alternative quantitation method.
Positive_regulation (upregulation) of IL11Ra in uterus
4) Confidence 0.47 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0.06 Pain Relevance 0
For each of the genes examined, upregulation during defective decidualization in IL11Ra-/- uterus is supported by existing data in the literature.
Positive_regulation (upregulation) of IL11Ra in uterus
5) Confidence 0.47 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0 Pain Relevance 0
The ECM genes COL3A1, SPARC, BGN and NID1 were among those upregulated in IL11Ra-/- uterus compared to wild type.
Positive_regulation (upregulated) of IL11Ra in uterus
6) Confidence 0.44 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0 Pain Relevance 0
Sustained activation of Stat3 in (intestinal) epithelium, brought about by activation of the Socs3-unresponsive IL10R, IL22R or gp130Y757F receptors, induces an anti-microbial response.
Positive_regulation (activation) of gp130Y757F in epithelium
7) Confidence 0.42 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.12 Pain Relevance 0.16
(IL11Ra-/-) had been previously generated by gene targeting, and serially crossed more than 10 generations onto a C57BL/6 background [9].
Positive_regulation (generated) of IL11Ra
8) Confidence 0.38 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC535545 Disease Relevance 0.08 Pain Relevance 0.03
The upregulation of TGF-beta receptor expression was preceded in this strain by an increased expression of IL-4, IL-13, and IL-13 receptor-alpha (at 8 h after bleomycin) and followed by an upregulation of gp130 and IL-6.
Positive_regulation (upregulation) of gp130 associated with sprains and strains
9) Confidence 0.36 Published 2004 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 15321784 Disease Relevance 0.38 Pain Relevance 0.34
After birth, gp130 signalling is required for the postnatal increase in the number of cholinergic cells (arrow period of ret dependence, dotted lines onset of ret and gp130 dependence, which are not precisely determined).
Positive_regulation (required) of gp130 associated with addiction
10) Confidence 0.14 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.13 Pain Relevance 0.13
Upregulation of galanin binding sites and GalR1 mRNA levels in the mouse locus coeruleus following chronic morphine treatments and precipitated morphine withdrawal.
Positive_regulation (Upregulation) of locus in locus coeruleus associated with locus ceruleus, withdrawal and morphine
11) Confidence 0.06 Published 2000 Journal Neuropsychopharmacology Section Title Doc Link 10882839 Disease Relevance 0.09 Pain Relevance 1.07

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