INT89253

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Context Info
Confidence 0.23
First Reported 2000
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 17
Disease Relevance 8.10
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mthfd1) oxidoreductase activity (Mthfd1) ligase activity (Mthfd1)
cytoplasm (Mthfd1)
Anatomy Link Frequency
T-cell 4
monocytes 3
macrophages 1
DCs 1
inferior 1
Mthfd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 34 100.00 Very High Very High Very High
cytokine 227 98.24 Very High Very High Very High
chemokine 43 89.80 High High
substance P 46 87.28 High High
tolerance 40 82.72 Quite High
Pain 20 82.36 Quite High
Inflammation 179 75.20 Quite High
antagonist 20 74.44 Quite High
metalloproteinase 2 69.96 Quite High
Arthritis 113 69.68 Quite High
Disease Link Frequency Relevance Heat
Decompression Sickness 8 100.00 Very High Very High Very High
Dengue 64 99.84 Very High Very High Very High
Adhesions 31 99.72 Very High Very High Very High
Cancer 412 98.16 Very High Very High Very High
Infection 123 97.72 Very High Very High Very High
Necrosis 17 95.16 Very High Very High Very High
Autoimmune Disease 320 92.96 High High
Cold Sores 368 90.56 High High
Disease 406 89.52 High High
Injury 25 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Various populations of resident DCs have been described in the lymph node with the help of an enhanced yellow fluorescent protein reporter under the control of the CD11c promoter [18]: subcapsular DCs with few dendrites and multiple large ruffles; DCs in the T cell zone; DCs in the B cell follicles; and perifollicular DCs, well positioned to acquire antigen from the lymph.
Regulation (populations) of DCs in T cell
1) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297591 Disease Relevance 0 Pain Relevance 0.19
Inner ear DCS was less responsive to hyperbaric oxygen treatment (p = 0.0001).
Regulation (responsive) of DCS in Inner ear associated with decompression sickness
2) Confidence 0.23 Published 2000 Journal Harefuah Section Abstract Doc Link 10883229 Disease Relevance 0.84 Pain Relevance 0.08
As seen in Figure 1D, CD40-silenced DCs exhibited markedly inferior allostimulatory activity as compared to control DCs.


Regulation (control) of DCs in inferior
3) Confidence 0.17 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.30 Pain Relevance 0.07
METHODS: Seven patients with chronic pelvic pain having failed standard medical or surgical therapy underwent a crossover, double-blind sham controlled tDCS treatment protocol consisting of 1 mA applied for 20 minutes on two consecutive days with 2 weeks of follow-up symptom recording.
Regulation (controlled) of tDCS
4) Confidence 0.17 Published 2009 Journal Brain Stimul Section Body Doc Link 20633407 Disease Relevance 0.25 Pain Relevance 0
Such alterations in DCs development and function are associated with tumor escape from immune-mediated surveillance[16,17].
Regulation (alterations) of DCs in DCs associated with cancer
5) Confidence 0.16 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 1.05 Pain Relevance 0.09
By selectively delivering the immune modulatory siRNA to the targeted DCs, it may be feasible to circumvent the clinical barriers associated with hydrodynamic administration.
Regulation (targeted) of DCs
6) Confidence 0.10 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.42 Pain Relevance 0.15
Both adaptive and innate immune cells, including B and T lymphocytes, monocytes, NK cells, and DCs, are affected.
Regulation (affected) of DCs in NK cells
7) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592775 Disease Relevance 0.90 Pain Relevance 0.07
Furthermore, studies investigating myeloid cell development and function have identified a common theme of a dynamic interplay between lineage-specific transcription factors and miRNAs. miRNAs involved in the regulation of granulocytes, monocytes, macrophages, DCs, NK, and natural killer T cells have been identified [9, 98].
Regulation (regulation) of DCs in granulocytes
8) Confidence 0.07 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.17 Pain Relevance 0
Many recent studies have illustrated the importance of immune regulation by neuropeptides through direct effects on T cells and indirect effects on antigen-presenting DCs (see Fig. 1).
Regulation (regulation) of DCs in T cells associated with neuropeptide
9) Confidence 0.06 Published 2001 Journal Respir Res Section Body Doc Link PMC2002076 Disease Relevance 0.32 Pain Relevance 0.25
Interestingly, the migration of monocyte-derived migratory dendritic cells (DCs) may be tightly regulated by interplay between different prostanoids.
Spec (may) Regulation (regulated) of DCs in monocyte
10) Confidence 0.05 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2718617 Disease Relevance 0.06 Pain Relevance 0.14
produced by NK cells can affect the maturation and effector functions of DCs, as well as other leukocytes that are responding to the infection [301].
Regulation (affect) of DCs in leukocytes associated with infection
11) Confidence 0.04 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.91 Pain Relevance 0.19
Both adaptive and innate immune cells, including B and T lymphocytes, monocytes, NK cells, and DCs, are affected.
Regulation (affected) of DCs in monocytes
12) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592775 Disease Relevance 0.90 Pain Relevance 0.07
Both adaptive and innate immune cells, including B and T lymphocytes, monocytes, NK cells, and DCs, are affected.
Regulation (affected) of DCs in T lymphocytes
13) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592775 Disease Relevance 0.90 Pain Relevance 0.07
Furthermore, studies investigating myeloid cell development and function have identified a common theme of a dynamic interplay between lineage-specific transcription factors and miRNAs. miRNAs involved in the regulation of granulocytes, monocytes, macrophages, DCs, NK, and natural killer T cells have been identified [9, 98].
Regulation (regulation) of DCs in macrophages
14) Confidence 0.02 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.17 Pain Relevance 0
Furthermore, studies investigating myeloid cell development and function have identified a common theme of a dynamic interplay between lineage-specific transcription factors and miRNAs. miRNAs involved in the regulation of granulocytes, monocytes, macrophages, DCs, NK, and natural killer T cells have been identified [9, 98].
Regulation (regulation) of DCs in monocytes
15) Confidence 0.02 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.17 Pain Relevance 0
Additionally, regulation on cell contact, ie, of NKs and DCs, is postulated.
Regulation (regulation) of DCs
16) Confidence 0.02 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654796 Disease Relevance 0.22 Pain Relevance 0.42
Adhesion molecules such as ICAM1 and ICAM3 are critical molecules generated by the T-cell during either phase and can bind to the adhesion molecules of DCs particularly DC-SIGN which is a known target of dengue.
Regulation (target) of DCs in T-cell associated with dengue and adhesions
17) Confidence 0.02 Published 2009 Journal Virol J Section Body Doc Link PMC2789730 Disease Relevance 0.51 Pain Relevance 0.17

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