INT89271

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Context Info
Confidence 0.52
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.41
Pain Relevance 4.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Serbp1) plasma membrane (Serbp1) nucleus (Serbp1)
cytoplasm (Serbp1)
Anatomy Link Frequency
spinal cord segment 1
Serbp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Endogenous opioid 1 99.84 Very High Very High Very High
withdrawal 7 99.52 Very High Very High Very High
Inflammation 5 99.24 Very High Very High Very High
opioid receptor 26 98.90 Very High Very High Very High
Spinal cord 6 98.72 Very High Very High Very High
allodynia 3 98.64 Very High Very High Very High
Morphine 131 98.40 Very High Very High Very High
Analgesic 11 98.06 Very High Very High Very High
tolerance 44 97.90 Very High Very High Very High
Brush evoked pain 1 87.52 High High
Disease Link Frequency Relevance Heat
Substance Withdrawal Syndrome 1 99.52 Very High Very High Very High
INFLAMMATION 5 99.24 Very High Very High Very High
Neuropathic Pain 9 98.64 Very High Very High Very High
Pain 6 79.28 Quite High
Nervous System Injury 1 75.08 Quite High
Toxicity 1 70.76 Quite High
Reprotox - General 3 1 65.36 Quite High
Newborn Drug Withdrawal Syndrome 4 48.60 Quite Low
Catatonia 2 36.72 Quite Low
Body Weight 11 22.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The M1 mRNA levels remained at this reduced degree of expression even after withdrawal symptoms had subsided.
Gene_expression (expression) of M1 mRNA associated with withdrawal
1) Confidence 0.52 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10884554 Disease Relevance 0.10 Pain Relevance 1.06
Administration of analgesic dose of morphine alone and in the presence of inflammation induced different alterations in the levels of G-protein mRNA.
Gene_expression (levels) of G-protein mRNA associated with inflammation, analgesic and morphine
2) Confidence 0.44 Published 2008 Journal Scand. J. Immunol. Section Abstract Doc Link 18052964 Disease Relevance 0.34 Pain Relevance 1.09
Administration of 18 microg of anti-FGF-2 antibodies attenuated mechanical allodynia at day 21 after SpNL and reduced FGF-2 and glial acidic fibrillary protein mRNA expression and immunoreactivity in the L5 spinal cord segment of rats with SpNL.
Gene_expression (expression) of protein mRNA in spinal cord segment associated with allodynia and spinal cord
3) Confidence 0.09 Published 2005 Journal J. Mol. Neurosci. Section Abstract Doc Link 16280602 Disease Relevance 0.83 Pain Relevance 0.88
Several reports provided possible mechanisms to explain the prenatally morphine-induced tolerance to morphine, including changes in opioid receptor density [17,27,28], intracellular cAMP levels [29], G protein mRNA levels [30], and expression of endogenous opioids [31].
Gene_expression (expression) of protein mRNA associated with endogenous opioid, tolerance, opioid receptor and morphine
4) Confidence 0.04 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2890660 Disease Relevance 0.14 Pain Relevance 1.49

General Comments

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