INT89281

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Context Info
Confidence 0.30
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.90
Pain Relevance 2.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DRB1) Golgi apparatus (HLA-DRB1) endoplasmic reticulum (HLA-DRB1)
plasma membrane (HLA-DRB1)
Anatomy Link Frequency
monocytes 5
T-cells 4
lymphocytes 3
blood 2
sputum 2
HLA-DRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
intrathecal 2 100.00 Very High Very High Very High
Angina 12 94.04 High High
Multiple sclerosis 8 93.84 High High
Neuritis 8 92.96 High High
metalloproteinase 2 89.28 High High
Inflammation 110 82.40 Quite High
chemokine 11 76.24 Quite High
cytokine 26 74.64 Quite High
antagonist 4 58.16 Quite High
beta blocker 10 43.12 Quite Low
Disease Link Frequency Relevance Heat
Disease 26 98.84 Very High Very High Very High
Breast Cancer 4 98.80 Very High Very High Very High
Hepatocellular Cancer 1 98.08 Very High Very High Very High
Coronary Artery Disease 8 96.36 Very High Very High Very High
Lumbar Puncture Related Headaches 2 95.04 Very High Very High Very High
Cv General 3 Under Development 12 94.04 High High
Demyelinating Disease 8 93.84 High High
Adenocarcinoma 90 93.52 High High
Optic Neuritis 8 92.96 High High
Hyperlipidemia 2 90.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment resulted in a decrease in the concentration of myelin basic protein, a decrease in the serum concentration of immunoglobulin G (IgG) and intrathecal IgG synthesis, an increase in the cerebrospinal fluid concentration of transforming growth factor-beta1, and changes in the expression of CD25, CD26, and human leukocyte antigen-DR (HLA-DR) on CD4 T-cells.
Negative_regulation (decrease) of Gene_expression (expression) of antigen-DR in T-cells associated with intrathecal
1) Confidence 0.30 Published 2000 Journal Eur. J. Neurol. Section Abstract Doc Link 10886311 Disease Relevance 0.66 Pain Relevance 0.63
Treatment resulted in a decrease in the concentration of myelin basic protein, a decrease in the serum concentration of immunoglobulin G (IgG) and intrathecal IgG synthesis, an increase in the cerebrospinal fluid concentration of transforming growth factor-beta1, and changes in the expression of CD25, CD26, and human leukocyte antigen-DR (HLA-DR) on CD4 T-cells.
Negative_regulation (decrease) of Gene_expression (expression) of antigen-DR in T-cells associated with intrathecal
2) Confidence 0.30 Published 2000 Journal Eur. J. Neurol. Section Abstract Doc Link 10886311 Disease Relevance 0.68 Pain Relevance 0.64
In the present study, we found that 2 mg inhaled FP decreased the expression of CD11b, mCD14, CD16, CD64, CD86, and HLA-DR on sputum monocytic cells after O3 challenge compared with placebo treatment.
Negative_regulation (decreased) of Gene_expression (expression) of HLA-DR in sputum
3) Confidence 0.13 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0.12 Pain Relevance 0
The 0.5 mg dose of FP decreased the expression of CD86 and HLA-DR on sputum monocytes after O3 challenge compared with placebo.
Negative_regulation (decreased) of Gene_expression (expression) of HLA-DR in monocytes
4) Confidence 0.13 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0.06 Pain Relevance 0
HLA-DRB1 expression significantly decreased with higher urinary arsenic levels (r2 = 0.8, p < 0.05).


Negative_regulation (decreased) of Gene_expression (expression) of HLA-DRB1
5) Confidence 0.11 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2290973 Disease Relevance 0.34 Pain Relevance 0
Furthermore, impaired expression of CD80, CD86, and HLA DR by blood DC in patients with breast cancer and hepatocellular carcinoma, may have contributed to their decreased immunostimulatory capacity [22], [23].
Negative_regulation (impaired) of Gene_expression (expression) of HLA DR in blood associated with hepatocellular cancer and breast cancer
6) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 1.21 Pain Relevance 0.07
Similarly, there was a negative correlation between sTNFR-2 and the relative number of lymphocytes and HLA-DR expressing lymphocytes (Table 3).
Negative_regulation (number) of Gene_expression (expressing) of HLA-DR in lymphocytes
7) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713422 Disease Relevance 0.57 Pain Relevance 0.03
Lipopolysaccharide (LPS)-receptor (CD14) and HLA-DR expression on monocytes and beta-integrins (CD11b, 11c, 49d) on monocytes and lymphocytes were measured by flow cytometry before and after treatment with atorvastatin for 8 weeks.
Negative_regulation (measured) of Gene_expression (expression) of HLA-DR in monocytes
8) Confidence 0.02 Published 2007 Journal Rom J Intern Med Section Abstract Doc Link 18333374 Disease Relevance 1.10 Pain Relevance 0.59
MAIN RESULTS: Absolute number of CD3+, CD4+, and CD8+, and expression of HLA-DR and activation marker CD25+, CD26+, and CD69+ decreased more in response to surgery after BAL.
Negative_regulation (decreased) of Gene_expression (expression) of HLA-DR
9) Confidence 0.01 Published 2005 Journal J Clin Anesth Section Body Doc Link 16297751 Disease Relevance 0.06 Pain Relevance 0
Lipopolysaccharide (LPS)-receptor (CD14) and HLA-DR expression on monocytes and beta-integrins (CD11b, 11c, 49d) on monocytes and lymphocytes were measured by flow cytometry before and after treatment with atorvastatin for 8 weeks.
Negative_regulation (measured) of in lymphocytes Gene_expression (expression) of HLA-DR in monocytes
10) Confidence 0.01 Published 2007 Journal Rom J Intern Med Section Abstract Doc Link 18333374 Disease Relevance 1.10 Pain Relevance 0.59

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