INT89285

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Context Info
Confidence 0.60
First Reported 2000
Last Reported 2005
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 0.09
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Drd3) signal transducer activity (Drd3)
Drd3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 2 100.00 Very High Very High Very High
cocaine 3 99.80 Very High Very High Very High
Nucleus accumbens 2 78.24 Quite High
Morphine 1 76.68 Quite High
Dynorphin 1 74.32 Quite High
substance P 1 73.52 Quite High
Nicotine 1 72.84 Quite High
Substantia nigra 2 57.04 Quite High
Enkephalin 1 25.00 Low Low
antagonist 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Recurrence 1 93.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Induction of dopamine D3 receptor gene expression in 6-hydroxydopamine-lesioned rats by repeated administration of levodopa had been suggested to be responsible for behavioural sensitization developing in these animals.
Positive_regulation (Induction) of Gene_expression (expression) of D3 receptor associated with dopamine
1) Confidence 0.60 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10886351 Disease Relevance 0 Pain Relevance 0.15
A single cocaine exposure increases BDNF and D3 receptor expression: implications for drug-conditioning.
Positive_regulation (increases) of Gene_expression (expression) of D3 receptor associated with cocaine
2) Confidence 0.50 Published 2005 Journal Neuroreport Section Title Doc Link 15671872 Disease Relevance 0.09 Pain Relevance 0.37

General Comments

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