INT89290

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Context Info
Confidence 0.45
First Reported 2000
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 10.40
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MUC1) plasma membrane (MUC1) nucleus (MUC1)
cytoplasm (MUC1)
Anatomy Link Frequency
eye 1
smooth muscle 1
epithelium 1
insula 1
frontoparietal 1
MUC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
insula 8 96.64 Very High Very High Very High
Chronic pancreatitis 2 93.40 High High
gABA 59 93.28 High High
Anterior cingulate 2 91.56 High High
fibrosis 3 91.00 High High
Inflammation 47 86.96 High High
cva 2 86.48 High High
cytokine 15 69.12 Quite High
Hippocampus 26 61.44 Quite High
Dysuria 1 47.28 Quite Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 201 99.98 Very High Very High Very High
Pox Virus Infection 41 99.98 Very High Very High Very High
Cancer 97 99.90 Very High Very High Very High
Bronchitis 7 99.76 Very High Very High Very High
Sprains And Strains 106 99.68 Very High Very High Very High
Skin Cancer 10 99.58 Very High Very High Very High
Pancreatic Cancer 27 98.92 Very High Very High Very High
Malignant Neoplastic Disease 10 98.20 Very High Very High Very High
Metaplasia 46 98.08 Very High Very High Very High
Sarcoma 7 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Eight genes (CYLD, DAF, DKFZp547A023, MUC1, OCLN, PLA2G2A, TIMP1, and ZCCHC4;Table 5) were significantly differentially regulated between normal controls and inflamed DC, and the direction of change was the same as that observed in IBD.
Regulation (regulated) of MUC1 associated with inflammatory bowel disease and skin cancer
1) Confidence 0.45 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1188246 Disease Relevance 1.39 Pain Relevance 0.04
against an epitope of the human MUC1 tandem repeat domain could
Regulation (epitope) of MUC1
2) Confidence 0.42 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC400208 Disease Relevance 0.58 Pain Relevance 0.03
At immunohistochemical phenotypification, the tumor was positive for vimentin, cytokeratins and epithelial membrane antigen (EMA), as well as for some other multidirectional antibodies, including a membranous reaction for CD99.
Regulation (positive) of EMA associated with cancer
3) Confidence 0.42 Published 2000 Journal Pathol. Int. Section Abstract Doc Link 10886744 Disease Relevance 0.70 Pain Relevance 0
Although alterations in mucin expression and/or mucin glycosylation have been implicated in the pathophysiology of dry eye, only a limited number of studies addressing these issues have been conducted.
Regulation (alterations) of mucin in eye associated with dry eye
4) Confidence 0.39 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0.70 Pain Relevance 0
Changes in MUC1 staining were observed in PanIN-3 and IDC, and E-cadherin staining was seen in neoplastic tissues.
Regulation (Changes) of MUC1
5) Confidence 0.33 Published 2006 Journal Rinsho Byori Section Abstract Doc Link 16789413 Disease Relevance 0.48 Pain Relevance 0.09
However, MUC1 mRNA levels increased progressively in culture but were not significantly affected by the presence of H. pylori (Figure 5B).
Neg (not) Regulation (affected) of MUC1
6) Confidence 0.26 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.12 Pain Relevance 0
After 6 h of co-culture H. pylori strain J99 wt did not affect the level of MUC1 on the cell surface, however, it led to depletion of 44% of cell surface MUC1 after 24 h infection compared to uninfected MKN7 cells (Figure 5D).
Neg (not) Regulation (affect) of MUC1 associated with sprains and strains and infection
7) Confidence 0.26 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.33 Pain Relevance 0
Disassociation could occur due to conformational changes in MUC1 following binding or due to shear forces following binding to the highly motile bacteria.
Regulation (changes) of MUC1
8) Confidence 0.26 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.13 Pain Relevance 0
Immunohistochemistry showed that the neoplastic cells were positive for smooth muscle actin and for h-caldesmon and negative for CD34, calponin, FVIII-associated antigen, S100, EMA and cytokeratin AE1 AE3.
Regulation (positive) of EMA in smooth muscle
9) Confidence 0.25 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2221972 Disease Relevance 0.85 Pain Relevance 0.04
There were no significant alterations in the amount of cellular MUC1 in either uninfected or infected MKN7 cells following knockdown of ADAM 17 or MMP-14.
Neg (no) Regulation (alterations) of MUC1
10) Confidence 0.23 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.33 Pain Relevance 0
MUC1 was positive in nonneoplastic tissues, PanIN-3, and IDC.
Regulation (positive) of MUC1
11) Confidence 0.20 Published 2006 Journal Rinsho Byori Section Abstract Doc Link 16789413 Disease Relevance 0.50 Pain Relevance 0.09
Reciprocally, PuM responses were observed following cortical stimulation, with response rate ranging from 14% (insula and frontoparietal opercular cortex) to 76–80% (temporal neocortex and mesial temporal regions).
Regulation (responses) of PuM in frontoparietal associated with insula
12) Confidence 0.15 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2972750 Disease Relevance 0.21 Pain Relevance 0.17
An open-label Phase 1 study of recombinant prime-boost poxviruses targeting CEA and MUC-1 in patients with advanced pancreatic cancer was conducted to determine safety, tolerability and obtain preliminary data on immune response and survival.


Regulation (targeting) of MUC-1 associated with pox virus infection and pancreatic cancer
13) Confidence 0.14 Published 2007 Journal J Transl Med Section Abstract Doc Link PMC2217514 Disease Relevance 0.59 Pain Relevance 0
Similarly, the concentrations of MUC-1, a progesterone-dependent glycoprotein secreted by the glands, are lower at day LH + 10 in women suffering recurrent spontaneous miscarriage than in fertile controls [55].
Regulation (concentrations) of MUC-1 in glands associated with reprotox - general 1
14) Confidence 0.11 Published 2007 Journal Placenta Section Body Doc Link PMC1878510 Disease Relevance 0.24 Pain Relevance 0.03
The changes in epithelial mucin stores, proliferating cells, and squamous cell metaplasia were most pronounced in COPD patients who had stopped smoking more than 3.5 years ago.
Regulation (changes) of mucin associated with nicotine addiction, pulmonary disease and metaplasia
15) Confidence 0.07 Published 2007 Journal Respir Res Section Body Doc Link PMC2214729 Disease Relevance 1.48 Pain Relevance 0.04
Reciprocally, PuM responses were observed following cortical stimulation, with response rate ranging from 14% (insula and frontoparietal opercular cortex) to 76–80% (temporal neocortex and mesial temporal regions).
Regulation (responses) of PuM in insula associated with insula
16) Confidence 0.05 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2972750 Disease Relevance 0.21 Pain Relevance 0.17
To investigate the relationship between GAD67 and MUC5AC gene expression (the dominant smoking-responsive mucin gene in the human airway epithelium [11,12,16]), the normalized expression of GAD67 was compared to MUC5AC expression.
Regulation (responsive) of mucin in epithelium associated with nicotine addiction
17) Confidence 0.02 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.62 Pain Relevance 0.05
Mucin genes are independently regulated and their expression is organ and cell type specific 16.
Regulation (regulated) of Mucin
18) Confidence 0.01 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1852400 Disease Relevance 0.50 Pain Relevance 0
With the mucomodulator approach, we intend to adjust or regulate the mucin macromolecules that give respiratory mucus its physical characteristics in order to minimize the aerosolization that facilitates transmission of airborne diseases.
Regulation (regulate) of mucin in respiratory associated with disease
19) Confidence 0.01 Published 2005 Journal BMC Pulm Med Section Body Doc Link PMC1208914 Disease Relevance 0.42 Pain Relevance 0.05

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