INT89291

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Context Info
Confidence 0.43
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.02
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (VIM) plasma membrane (VIM) cytoskeleton (VIM)
cytoplasm (VIM)
Anatomy Link Frequency
epithelial cells 1
VIM (Homo sapiens)
Pain Link Frequency Relevance Heat
Dysuria 1 43.20 Quite Low
Chronic pancreatitis 10 14.20 Low Low
Inflammation 5 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Immobilon 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 125 99.90 Very High Very High Very High
Pancreatic Cancer 48 98.56 Very High Very High Very High
Sarcoma 5 97.68 Very High Very High Very High
Carcinoma 12 97.32 Very High Very High Very High
Disease 2 94.28 High High
Breast Cancer 113 79.28 Quite High
Metastasis 5 59.52 Quite High
Urethral Stricture 1 44.72 Quite Low
Pancreatitis 10 14.20 Low Low
Hypersensitivity 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Role of glycosylation in vimentin antigenicity
Regulation (Role) of vimentin
1) Confidence 0.43 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2528299 Disease Relevance 0.24 Pain Relevance 0
At immunohistochemical phenotypification, the tumor was positive for vimentin, cytokeratins and epithelial membrane antigen (EMA), as well as for some other multidirectional antibodies, including a membranous reaction for CD99.
Regulation (positive) of vimentin associated with cancer
2) Confidence 0.40 Published 2000 Journal Pathol. Int. Section Abstract Doc Link 10886744 Disease Relevance 0.70 Pain Relevance 0
The highest up-regulated gene in the WalBC cell line was cytokeratin 17 while vimentin was down regulated.
Regulation (regulated) of vimentin
3) Confidence 0.08 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2263075 Disease Relevance 0.33 Pain Relevance 0
A 4.7 fold down regulation of VIM expression and absence of vimentin immunoreactivity in the in situ tumor compared to normal mammary cells suggests both the tumor and the derived cell line have not undergone an epithelial-to-mesenchymal transition associated with increased invasive/migratory properties of epithelial cells [43,44].
Regulation (immunoreactivity) of vimentin in epithelial cells associated with cancer
4) Confidence 0.08 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2263075 Disease Relevance 0.75 Pain Relevance 0

General Comments

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