INT89293

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 29
Total Number 29
Disease Relevance 22.14
Pain Relevance 15.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CCR5) plasma membrane (CCR5) cell-cell signaling (CCR5)
cytoplasm (CCR5) signal transducer activity (CCR5)
Anatomy Link Frequency
macrophages 14
monocytes 6
lymphocytes 6
T cells 6
immune cells 2
CCR5 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 116 100.00 Very High Very High Very High
Inflammation 83 100.00 Very High Very High Very High
Morphine 61 100.00 Very High Very High Very High
Opioid 62 99.98 Very High Very High Very High
MU agonist 2 99.96 Very High Very High Very High
narcan 5 99.82 Very High Very High Very High
antagonist 34 99.00 Very High Very High Very High
opioid receptor 17 99.00 Very High Very High Very High
Arthritis 68 98.88 Very High Very High Very High
methadone 11 98.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 931 100.00 Very High Very High Very High
INFLAMMATION 87 100.00 Very High Very High Very High
Adhesions 10 100.00 Very High Very High Very High
Anaplastic Astrocytoma 5 99.48 Very High Very High Very High
Infection 278 99.44 Very High Very High Very High
Juvenile Chronic Polyarthritis 56 98.88 Very High Very High Very High
Sprains And Strains 16 98.44 Very High Very High Very High
Toxicity 52 98.12 Very High Very High Very High
Encephalopathy 2 97.68 Very High Very High Very High
Disease Progression 15 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This enhancement was associated with the up-regulation of expression of CCR5, a primary coreceptor for macrophage-tropic HIV entry into macrophages.
Positive_regulation (up-regulation) of Gene_expression (expression) of CCR5 in macrophages associated with acquired immune deficiency syndrome or hiv infection
1) Confidence 0.70 Published 2002 Journal J. Infect. Dis. Section Abstract Doc Link 11756991 Disease Relevance 1.07 Pain Relevance 0.70
Methadone, a regimen for the treatment of opioid dependency, was found to induce the expression of CCR5, a co-receptor for human immunodeficiency virus (HIV)/simian form of HIV (SIV) entry, on human CEM x174 lymphocytes.
Positive_regulation (induce) of Gene_expression (expression) of CCR5 in lymphocytes associated with acquired immune deficiency syndrome or hiv infection, methadone and opioid
2) Confidence 0.70 Published 2002 Journal FEBS Lett. Section Abstract Doc Link 12023039 Disease Relevance 0.44 Pain Relevance 0.54
The ability of MNTX to block opioid-induced CCR5 expression and HIV replication at clinically relevant doses may have additional benefit for opioid abusers with HIV infection, or patients with AIDS pain receiving opioids.
Positive_regulation (induced) of Gene_expression (expression) of CCR5 associated with pain, acquired immune deficiency syndrome or hiv infection, opioid and infection
3) Confidence 0.70 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14560041 Disease Relevance 1.78 Pain Relevance 1.59
Morphine induces gene expression of CCR5 in human CEMx174 lymphocytes.
Positive_regulation (induces) of Gene_expression (expression) of CCR5 in lymphocytes associated with morphine
4) Confidence 0.69 Published 2000 Journal J. Biol. Chem. Section Title Doc Link 10887175 Disease Relevance 0.61 Pain Relevance 0.32
Morphine significantly up-regulated CCR5 receptor expression and inhibited the endogenous production of macrophage inflammatory protein-1beta in neonatal MDM.
Positive_regulation (up-regulated) of Gene_expression (expression) of CCR5 in macrophage associated with inflammation and morphine
5) Confidence 0.66 Published 2003 Journal Pediatr. Res. Section Abstract Doc Link 12736382 Disease Relevance 1.44 Pain Relevance 0.86
Our results support the hypothesis that opioids play a significant role in the susceptibility of the CNS to HIV-1 infection and subsequent encephalopathy by inhibiting local production of HIV-1-protective chemokines (IL-8 and macrophage-inflammatory protein-1beta) and enhancing expression of HIV-1 entry coreceptor genes (CCR3, CCR5, and CXCR2) within the CNS.
Positive_regulation (enhancing) of Gene_expression (expression) of CCR5 in macrophage associated with chemokine, inflammation, encephalopathy, acquired immune deficiency syndrome or hiv infection, opioid and infection
6) Confidence 0.63 Published 2002 Journal J. Immunol. Section Abstract Doc Link 12244149 Disease Relevance 0.83 Pain Relevance 1.30
Our results show that NHA treated with morphine showed significant downregulation of the gene expression of beta chemokines, MCP-1, and MIP-1 beta, while reciprocally upregulating the expression of their specific receptors, CCR2b, CCR3, and CCR5 as detected by real-time quantitative PCR.
Positive_regulation (upregulating) of Gene_expression (expression) of CCR5 in NHA associated with chemokine and morphine
7) Confidence 0.62 Published 2005 Journal Clin. Immunol. Section Abstract Doc Link 15893700 Disease Relevance 0 Pain Relevance 0.87
Activation of opioid receptors by morphine was previously shown to specifically induce the expression of chemokine receptor CCR5, promoting simian AIDS virus entry and replication in immune cells.
Positive_regulation (induce) of Gene_expression (expression) of chemokine receptor CCR5 in immune cells associated with chemokine, acquired immune deficiency syndrome or hiv infection, opioid receptor and morphine
8) Confidence 0.61 Published 2002 Journal Exp. Cell Res. Section Abstract Doc Link 12413885 Disease Relevance 0.10 Pain Relevance 0.34
Morphine sulfate induces the formation and expression of both forms of CCR5 whereas RANTES, MIP-1alpha or MIP-1beta inhibits them.
Positive_regulation (induces) of Gene_expression (expression) of CCR5 associated with morphine
9) Confidence 0.50 Published 2002 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 12163044 Disease Relevance 0.24 Pain Relevance 0.18
Furthermore, MNTX abolished morphine-mediated up-regulation of CCR5 receptor expression.
Positive_regulation (up-regulation) of Gene_expression (expression) of CCR5 associated with morphine
10) Confidence 0.50 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14560041 Disease Relevance 1.44 Pain Relevance 1.61
We described previously that expression levels of the chemokine receptor, CCR5, and the beta2-integrin, Mac-1, were down-regulated on primary monocytes after incubation in supernatants from human carcinoma cell lines, and that this down-regulation resulted in impaired monocyte function with respect to migration and adhesion.
Positive_regulation (levels) of Gene_expression (expression) of CCR5 in monocyte associated with chemokine, carcinoma and adhesions
11) Confidence 0.48 Published 2003 Journal FASEB J. Section Abstract Doc Link 12490541 Disease Relevance 0.48 Pain Relevance 0.14
Functional studies revealed that a combination treatment of cells with morphine, an agonist for mu, and MIP-1beta, a ligand for CCR5, suppresses the inhibitory effect of MIP-1beta and increases the stimulatory effect of morphine on CCR5 expression.
Positive_regulation (increases) of Gene_expression (expression) of CCR5 associated with agonist and morphine
12) Confidence 0.47 Published 2002 Journal Exp. Cell Res. Section Abstract Doc Link 12413885 Disease Relevance 0.05 Pain Relevance 0.64
Treatment of NHAs with morphine suppressed IL-8 and macrophage-inflammatory protein-1beta gene expression, whereas expression of their receptor genes, CCR3 and CCR5, was simultaneously enhanced.
Positive_regulation (enhanced) of Gene_expression (expression) of CCR5 in macrophage associated with inflammation and morphine
13) Confidence 0.46 Published 2002 Journal J. Immunol. Section Abstract Doc Link 12244149 Disease Relevance 1.15 Pain Relevance 1.37
Morphine was previously found to compromise the chemotactic mobility of leukocytic cells toward inflammatory sites as well as induce the expression of chemokine receptor CCR5, a coreceptor for HIV entry, on lymphocytes.
Positive_regulation (nduce ) of Gene_expression (xpression ) of chemokine receptor CCR5 in lymphocytes associated with chemokine, inflammation, acquired immune deficiency syndrome or hiv infection and morphine
14) Confidence 0.45 Published 2003 Journal Exp. Cell Res. Section Abstract Doc Link 14644156 Disease Relevance 0.38 Pain Relevance 0.55
Additionally, MDMs can be infected after differentiation and are more susceptible to new infection in comparison to freshly isolated monocytes due to increased expression of the HIV co-receptor CCR5 [26]; however, this infection is limited, and the production of virus is hindered at many steps which will be discussed.
Positive_regulation (increased) of Gene_expression (expression) of CCR5 in monocytes associated with acquired immune deficiency syndrome or hiv infection and infection
15) Confidence 0.45 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 1.22 Pain Relevance 0.11
Finally, changes in T-cell receptor expression as a person ages, such as increased expression of the CCR5 co-receptor, is important in the pathogenesis of HIV infection and could also influence disease progression (Kalayjian et al 2003; Yung and Mo 2003).
Positive_regulation (increased) of Gene_expression (expression) of CCR5 co-receptor in T-cell associated with acquired immune deficiency syndrome or hiv infection, disease progression and infection
16) Confidence 0.39 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682378 Disease Relevance 2.17 Pain Relevance 0
To test for CD4 and CCR5 dependencies, QT6 cells were transfected with 5 or 0.5 ?
Positive_regulation (test) of Gene_expression (dependencies) of CCR5
17) Confidence 0.33 Published 2008 Journal Retrovirology Section Body Doc Link PMC2576352 Disease Relevance 0.36 Pain Relevance 0
To test for CD4 and CCR5 dependencies, QT6 cells were transfected with 5 or 0.5 ?
Positive_regulation (for) of Gene_expression (dependencies) of CCR5
18) Confidence 0.33 Published 2008 Journal Retrovirology Section Body Doc Link PMC2576352 Disease Relevance 0.36 Pain Relevance 0
1 1:6 (CD49d clone P4C2, CYTEL CORPORATION, San Diego, CA, USA) or incubated for two hours at room temperature with one of the following mAbs: mouse anti-human CXCR3 (clone 1C6), anti-CCR5 (clone 2D7), anti-CCR3 (clone 7B11), anti-CCL17/TARC (clone 2D8) at 10 ?
Positive_regulation (incubated) of Gene_expression (one) of CCR5 in 1C6
19) Confidence 0.30 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0 Pain Relevance 0.08
It may serve to facilitate direct HIV infection of T cells, for example by promoting expression of CCR5 [13].
Positive_regulation (promoting) of Gene_expression (expression) of CCR5 in T cells associated with acquired immune deficiency syndrome or hiv infection and infection
20) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914784 Disease Relevance 1.61 Pain Relevance 0.22

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox