INT89294

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Context Info
Confidence 0.68
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 53
Total Number 54
Disease Relevance 43.90
Pain Relevance 12.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ccr3) signal transduction (Ccr3) extracellular space (Ccr3)
plasma membrane (Ccr3) signal transducer activity (Ccr3)
Anatomy Link Frequency
brain 6
macrophages 5
lymphocytes 5
lung 4
monocytes 3
Ccr3 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 1580 100.00 Very High Very High Very High
antagonist 81 100.00 Very High Very High Very High
Inflammation 1174 99.66 Very High Very High Very High
Central nervous system 500 98.18 Very High Very High Very High
rheumatoid arthritis 204 97.76 Very High Very High Very High
Multiple sclerosis 614 97.64 Very High Very High Very High
Neuritis 100 95.16 Very High Very High Very High
Inflammatory response 97 93.32 High High
cytokine 597 90.64 High High
Osteoarthritis 100 84.56 Quite High
Disease Link Frequency Relevance Heat
Infection 866 99.74 Very High Very High Very High
Hypersensitivity 151 99.68 Very High Very High Very High
INFLAMMATION 1237 99.66 Very High Very High Very High
Cerebral Malaria 741 99.62 Very High Very High Very High
Malaria 912 99.54 Very High Very High Very High
Rhinitis 100 99.40 Very High Very High Very High
Asthma 552 99.36 Very High Very High Very High
Pulmonary Disease 74 98.88 Very High Very High Very High
Bronchial Hyperreactivity 1 98.56 Very High Very High Very High
Demyelinating Disease 792 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compared to wild type EAN mice, TNFR1-/- EAN mice developed significantly more severe clinical signs, in parallel with enhanced numbers of inflammatory infiltrating cells in peripheral nerves and splenic P0-reactive T cell proliferation, as well as increased obviously MHC class II and CCR3 expression on the macrophages in the cauda equina.
Gene_expression (expression) of CCR3 in macrophages associated with inflammation and neuritis
1) Confidence 0.68 Published 2007 Journal J. Neuroimmunol. Section Abstract Doc Link 17428547 Disease Relevance 0.69 Pain Relevance 0.62
Our results show that RAE and CsA downregulate CCR3 expression and CD4+CD8?
Gene_expression (expression) of CCR3
2) Confidence 0.65 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.30 Pain Relevance 0.05
To detect CCR3 expression on
Gene_expression (expression) of CCR3
3) Confidence 0.65 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.16 Pain Relevance 0
expression of CCR3 was analyzed by flow cytometry.
Spec (analyzed) Gene_expression (expression) of CCR3
4) Confidence 0.65 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.16 Pain Relevance 0
PCR

products for eotaxin2, CCR3, IL-13, TARC, and TNF- ?

Gene_expression (products) of CCR3
5) Confidence 0.65 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.27 Pain Relevance 0.09
In addition, tryptase/chymase double-positive mast cells express CCR3 and are attracted by eotaxin (Ochi et al. 1999; Romagnani et al. 1999).
Gene_expression (express) of CCR3 in mast cells
6) Confidence 0.62 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535612 Disease Relevance 0.56 Pain Relevance 0
The results of this study demonstrate that the increase in production of RANTES follows the course of P. yoelii 17XL malaria infection, thus RANTES and its receptors CCR1, CCR3 and CCR5 were detected at their highest levels at day six and day eight post-infection.
Gene_expression (detected) of CCR3 associated with malaria and infection
7) Confidence 0.55 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.01 Pain Relevance 0.16
The expressions of all the C-C chemokine receptors for RANTES, CCR1, CCR3 and CCR5, were upregulated in the brains of P. yoelii 17XL-infected mice.
Gene_expression (expressions) of CCR3 in brains associated with chemokine
8) Confidence 0.55 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.49 Pain Relevance 0.40
End othelial cells interacting with P. yoelii 17XL-parasitized erythrocytes have been shown to be induced to produce and present specific chemokines, such as RANTES, which can lure CCR1, CCR3 and CCR5 expressing cells into the brain [36].
Gene_expression (expressing) of CCR3 in brain associated with chemokine
9) Confidence 0.55 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.38 Pain Relevance 0.12
Tkachuk and colleagues observed that malaria infection induced the expression of CCR3 and CCR5 on placental macrophages in pregnant women [22].
Gene_expression (expression) of CCR3 in macrophages associated with malaria and infection
10) Confidence 0.55 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.55 Pain Relevance 0.20
RANTES binds to a variety of receptors including CCR1, CCR3 and CCR5, expressed by monocytes/macrophages, memory T-cells, eosinophils, endothelial cells, basophils and mast cells [11].
Gene_expression (expressed) of CCR3 in macrophages
11) Confidence 0.55 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.20 Pain Relevance 0.36
The expression of RANTES and its corresponding receptors, CCR1, CCR3 and CCR 5, were altered by P. yoelii 17XL infection and were significantly up-regulated (p < 0.002 for RANTES, p < 0.036 for CCR1, p < 0.033 for CCR3 and p < 0.026 for CCR5) in the brain during malaria infection.
Gene_expression (expression) of CCR3 in brain associated with malaria and infection
12) Confidence 0.55 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.77 Pain Relevance 0.20
Messenger RNA expression levels of CCR1, CCR3 and CCR5 were approximately two to three fold higher in infected mice than in controls [Figures 3B, 3C &3D].
Gene_expression (expression) of CCR3
13) Confidence 0.55 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.69 Pain Relevance 0.13
The receptors for MIP-1 delta, CCR1 and CCR3, were expressed in both osteoclast precursors and mature, bone-resorbing osteoclasts as shown by qRT-PCR and Western analysis.
Gene_expression (expressed) of CCR3 in osteoclasts
14) Confidence 0.54 Published 2008 Journal Cancer Res. Section Abstract Doc Link 18316587 Disease Relevance 1.55 Pain Relevance 0.19
In contrast, Th2 lymphocytes were reported to produce CCR3, CCR4, and CCR8 [5,12,13,18,25].
Gene_expression (produce) of CCR3 in lymphocytes
15) Confidence 0.52 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.44 Pain Relevance 0.50
Other authors assigned CXCR3 and CCR5 proteins predominantly to Th1 lymphocytes, whereas Th2 lymphocytes produced CCR3 and CCR4 [12,13,18,26].
Gene_expression (produced) of CCR3 in lymphocytes
16) Confidence 0.52 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.94 Pain Relevance 0.48
To evaluate the efficacy of RAE and CsA treatments on granulocytes population and CCR3 expression, we compared the effects of RAE
Gene_expression (expression) of CCR3 in granulocytes
17) Confidence 0.50 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.17 Pain Relevance 0
mRNA gene expression in lung cells expressing CCR3 was significantly decreased
Gene_expression (expressing) of CCR3 in lung
18) Confidence 0.50 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.56 Pain Relevance 0.07
and CsA on intracellular CCR3 expression in OVA-induced asthma lung cells by
Gene_expression (expression) of CCR3 in lung associated with asthma
19) Confidence 0.50 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.42 Pain Relevance 0.08
and CsA on intracellular CCR3 expression in OVA-induced asthma lung cells by
Gene_expression (expression) of CCR3 in lung associated with asthma
20) Confidence 0.50 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.17 Pain Relevance 0

General Comments

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