INT89304

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Context Info
Confidence 0.35
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 0.93
Pain Relevance 5.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (ST8SIA2) Golgi apparatus (ST8SIA2) carbohydrate metabolic process (ST8SIA2)
Anatomy Link Frequency
vestibule 3
pore 2
external 1
ST8SIA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 829 99.98 Very High Very High Very High
sodium channel 8 99.84 Very High Very High Very High
addiction 80 95.36 Very High Very High Very High
local anesthetic 21 94.76 High High
Nav1.1 40 64.24 Quite High
Nav1.2 24 54.76 Quite High
abdominal pain 1 33.04 Quite Low
Nav1.6 8 6.20 Low Low
conotoxin 12 5.00 Very Low Very Low Very Low
Glutamate 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fatigue 10 100.00 Very High Very High Very High
Poisoning 3 94.40 High High
Shellfish Poisoning 11 93.00 High High
Paralysis 8 92.52 High High
Death 4 78.64 Quite High
Toxicity 12 49.08 Quite Low
Fever 1 34.88 Quite Low
Abdominal Pain 1 33.04 Quite Low
Exanthema 1 31.36 Quite Low
Heart Arrhythmia 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
That channel's P region structure is expected to be different because selectivity is determined by side-chain interactions rather than by main-chain carbonyls, and its outer vestibule accommodates relatively large toxin molecules, tetrodotoxin (TTX) and saxitoxin (STX), which interact with selectivity ring residues.
STX Binding (interact) of in vestibule associated with tetrodotoxin
1) Confidence 0.35 Published 2000 Journal Biochemistry Section Abstract Doc Link 10889022 Disease Relevance 0 Pain Relevance 0.10
Samples testing positive for PSTs (n = 7) were further analyzed with saxiphilin- and voltage-gated sodium channel [(3)H]-STX-binding radioreceptor assays and liquid chromatography using fluorescence and mass spectrometric analysis.
STX Binding (binding) of associated with sodium channel
2) Confidence 0.31 Published 2005 Journal Environ. Toxicol. Section Abstract Doc Link 15892061 Disease Relevance 0 Pain Relevance 0.05
The demonstration that mutation of residues critically involved in permeation and selectivity greatly reduced or abolished toxin affinity established beyond any doubt that TTX and STX bind and block deep within the outer vestibule.
STX Binding (bind) of in vestibule associated with tetrodotoxin
3) Confidence 0.28 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2852835 Disease Relevance 0 Pain Relevance 0.56
The most direct way to ask the question of gating effects of TTX/STX binding is measurement of gating currents.
STX Binding (binding) of associated with tetrodotoxin
4) Confidence 0.28 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2852835 Disease Relevance 0 Pain Relevance 0.90
Hille [6] summarized the argument derived from functional data that TTX and STX bind in the external channel vestibule and block Na current by occluding the pore completely.
STX Binding (bind) of in pore associated with tetrodotoxin
5) Confidence 0.28 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2852835 Disease Relevance 0 Pain Relevance 0.54
Both the Lipkind-Fozzard and the Tikhonov-Zhorov models of TTX/STX binding assume that the outer vestibule is normally rigid.
STX Binding (binding) of in vestibule associated with tetrodotoxin
6) Confidence 0.22 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2852835 Disease Relevance 0 Pain Relevance 0.56
He confirmed that TTX and STX appeared to be completely specific for Na channels and bound with 1:1 stoichiometry.
STX Spec (appeared) Binding (bound) of associated with tetrodotoxin
7) Confidence 0.21 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2852835 Disease Relevance 0 Pain Relevance 0.49
STX loss of energy of interaction with mutation of Asp-1532 was ?
STX Binding (interaction) of associated with fatigue
8) Confidence 0.19 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2852835 Disease Relevance 0.10 Pain Relevance 0.69
Since TTX and STX bind selectively with one toxin per channel, tritiated toxin has been successfully used to determine the density of Na channels in the membrane [27].
STX Binding (bind) of associated with tetrodotoxin
9) Confidence 0.19 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2852835 Disease Relevance 0.09 Pain Relevance 0.38
Indeed, there are experimental results indicating that several stages in TTX/STX binding do occur [51,68].
STX Binding (binding) of associated with tetrodotoxin
10) Confidence 0.18 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2852835 Disease Relevance 0 Pain Relevance 0.23
This is mediated by the interaction between the positively charged guanidinium groups of STX with negatively charged carboxyl groups at site 1 of the Na+ channel, thereby blocking the pore (Figure 1) [28–30].
STX Neg (negatively) Binding (interaction) of in pore
11) Confidence 0.10 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2920551 Disease Relevance 0.74 Pain Relevance 0
In order to account for the biphasic time course of block during recovery, the authors developed a three state model in which STX binds to a transient closed state which is traversed during depolarization and repolarization.
STX Binding (binds) of
12) Confidence 0.05 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2866490 Disease Relevance 0 Pain Relevance 0.20
The author proposed that divalent or trivalent cations bind to a deep site in the channel thereby reducing TTX or STX binding to an external receptor.
STX Binding (binding) of in external associated with tetrodotoxin
13) Confidence 0.03 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2866490 Disease Relevance 0 Pain Relevance 0.53

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