INT89308

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Context Info
Confidence 0.49
First Reported 2000
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 10.64
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
eye 2
thyroid 2
IFNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 125 100.00 Very High Very High Very High
Multiple sclerosis 354 96.40 Very High Very High Very High
rheumatoid arthritis 102 95.76 Very High Very High Very High
headache 7 95.60 Very High Very High Very High
Pain 69 93.64 High High
depression 19 88.84 High High
imagery 55 74.16 Quite High
cytokine 127 71.44 Quite High
methadone 10 66.96 Quite High
fibrosis 10 64.20 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 138 100.00 Very High Very High Very High
Rhinitis 11 100.00 Very High Very High Very High
Pancreatitis 9 100.00 Very High Very High Very High
Conjunctiva Disease 1 99.86 Very High Very High Very High
Autoimmune Disease 17 99.74 Very High Very High Very High
Chronic Hepatitis 9 99.68 Very High Very High Very High
Sleep Disorders 24 99.12 Very High Very High Very High
Infection 76 98.88 Very High Very High Very High
Hepatitis C Virus Infection 160 97.52 Very High Very High Very High
Demyelinating Disease 386 96.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two patients experienced episodes of acute pancreatitis shortly after starting treatment with interferon alfa-2b (IFN-alpha) for a chronic hepatitis C infection.
Positive_regulation (experienced) of IFN-alpha Binding (treatment) of associated with chronic hepatitis, pancreatitis and infection
1) Confidence 0.49 Published 2000 Journal Gastroenterology Section Abstract Doc Link 10889173 Disease Relevance 0.66 Pain Relevance 0
CONCLUSIONS: Combining the sequence of the endomorphin, it is suggested that the Pro(39) residue is one of the constituents of the analgesic domain of IFN-alpha and contributes to IFN-alpha binding to the mu opioid receptor.


Positive_regulation (contributes) of IFN-alpha Binding (binding) of
2) Confidence 0.35 Published 2002 Journal Neuroimmunomodulation Section Body Doc Link 12207158 Disease Relevance 0 Pain Relevance 0
Moreover, these drugs will probably be used in combination with interferon, at least initially.


Positive_regulation (used) of interferon Binding (combination) of
3) Confidence 0.32 Published 2007 Journal Addiction Science & Clinical Practice Section Body Doc Link PMC2797096 Disease Relevance 0.91 Pain Relevance 0.09
However, CIFN may induce thyroid autoimmunity in a larger proportion compared with IFN-?
Positive_regulation (proportion) of IFN Binding (compared) of in thyroid associated with autoimmune disease
4) Confidence 0.28 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727894 Disease Relevance 1.14 Pain Relevance 0.04
Sjogren et al (2005) have shown that combination therapy of CIFN and ribavirin provides a significantly better treatment response compared with the combination of IFN-?
Positive_regulation (provides) of IFN Binding (combination) of
5) Confidence 0.28 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727894 Disease Relevance 0.25 Pain Relevance 0
Stimulation with PHA and PMA further augmented the magnitude of IFN-?
Positive_regulation (augmented) of IFN Binding (magnitude) of
6) Confidence 0.17 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 1.11 Pain Relevance 0.53
First-line treatment of RRMS is currently based on immunomodulatory drugs, including recombinant IFN?
Positive_regulation (based) of IFN Binding (recombinant) of
7) Confidence 0.13 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938285 Disease Relevance 1.35 Pain Relevance 0.51
Such comparisons have led to investigations of osteopontin (OPN), myelin basic protein (MBP), IFN-?
Spec (investigations) Positive_regulation (led) of IFN Binding (investigations) of
8) Confidence 0.11 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998807 Disease Relevance 0.91 Pain Relevance 0.26
A recent study was conducted to determine whether combination daclizumab and IFN ?
Positive_regulation (conducted) of IFN Spec (determine) Binding (determine) of
9) Confidence 0.11 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2998807 Disease Relevance 0.88 Pain Relevance 0.17
In fact, transfer of primed CD4+ T cells constitutively expressing SOCS-5 along with eye drop challenges in a murine allergic conjunctivitis model resulted in attenuated eosinophilic inflammation with enhanced IFN-?
Positive_regulation (resulted) of IFN Binding (inflammation) of in eye associated with rhinitis, conjunctiva disease and inflammation
10) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.07 Pain Relevance 0.08
This is particularly important as injections of IFN ?
Positive_regulation (important) of IFN Binding (injections) of
11) Confidence 0.03 Published 2008 Journal BMC Neurol Section Body Doc Link PMC2577094 Disease Relevance 0.53 Pain Relevance 0.22
Clinical experience suggests that patients with CHC endorse sleeping problems, and large studies of CHC patients undergoing antiviral therapy with interferon (IFN)-?
Positive_regulation (undergoing) of IFN Binding (therapy) of
12) Confidence 0.03 Published 2010 Journal Curr Hepat Rep Section Body Doc Link PMC2829649 Disease Relevance 0.91 Pain Relevance 0.08
Clinical experience suggests that patients with CHC endorse sleeping problems, and large studies of CHC patients undergoing antiviral therapy with interferon (IFN)-?
Positive_regulation (antiviral) of IFN Binding (therapy) of
13) Confidence 0.03 Published 2010 Journal Curr Hepat Rep Section Body Doc Link PMC2829649 Disease Relevance 0.91 Pain Relevance 0.08

General Comments

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