INT89326

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Context Info
Confidence 0.37
First Reported 2000
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.67
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Drd3) plasma membrane (Drd3) signal transducer activity (Drd3)
Anatomy Link Frequency
nucleus accumbens 1
Drd3 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 19 100.00 Very High Very High Very High
Dynorphin 3 100.00 Very High Very High Very High
substance P 2 99.76 Very High Very High Very High
fluoxetine 6 99.48 Very High Very High Very High
Nucleus accumbens 8 99.32 Very High Very High Very High
Neuropeptide 5 96.40 Very High Very High Very High
Endep 8 96.32 Very High Very High Very High
Enkephalin 3 91.92 High High
Desipramine 2 88.48 High High
antidepressant 12 86.60 High High
Disease Link Frequency Relevance Heat
Sprains And Strains 3 99.08 Very High Very High Very High
Shock 2 91.76 High High
Targeted Disruption 2 75.00 Quite High
Disease 1 60.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By in situ hybridization, we detected striatal dopamine D1, D2, D3 receptor, and substance P mRNAs at G13, preproenkephalin A mRNA at G14 and dynorphin mRNA at G17 in normal mice.
Transcription (detected) of D3 receptor associated with dopamine, dynorphin and substance p
1) Confidence 0.37 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10998124 Disease Relevance 0.07 Pain Relevance 0.57
There was no difference in the modulation of D3 receptor density and dynorphin (DYN) mRNA expression between the two mouse strains.
Transcription (expression) of D3 receptor associated with dynorphin and sprains and strains
2) Confidence 0.33 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16930409 Disease Relevance 0.42 Pain Relevance 0.37
In contrast, treatments for 21 days (with all drugs except fluoxetine) significantly increased D3 receptor mRNA expression in the shell of nucleus accumbens; D3 receptor binding was also significantly increased by amitriptyline or fluoxetine after a 42-day treatment.
Transcription (expression) of D3 receptor in nucleus accumbens associated with nucleus accumbens, endep and fluoxetine
3) Confidence 0.24 Published 2000 Journal Mol. Psychiatry Section Abstract Doc Link 10889548 Disease Relevance 0.09 Pain Relevance 0.84
Short-term drug treatments had variable effects on D3 receptor mRNA expression.
Transcription (expression) of D3 receptor
4) Confidence 0.24 Published 2000 Journal Mol. Psychiatry Section Abstract Doc Link 10889548 Disease Relevance 0.09 Pain Relevance 0.79

General Comments

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