INT89327

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Context Info
Confidence 0.54
First Reported 2000
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.32
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Drd3) plasma membrane (Drd3) signal transducer activity (Drd3)
Anatomy Link Frequency
nucleus accumbens 4
brains 2
Drd3 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 8 100.00 Very High Very High Very High
Endep 12 99.80 Very High Very High Very High
fluoxetine 9 99.68 Very High Very High Very High
Nucleus accumbens 12 99.32 Very High Very High Very High
antidepressant 18 98.76 Very High Very High Very High
dopamine receptor 8 90.16 High High
Desipramine 3 83.92 Quite High
long-term potentiation 5 78.48 Quite High
nMDA receptor 1 68.28 Quite High
gABA 7 7.92 Low Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 3 88.84 High High
Shock 5 87.20 High High
Cognitive Disorder 18 50.00 Quite Low
Targeted Disruption 6 50.00 Quite Low
Watson Syndrome 28 27.36 Quite Low
Learning Disorders 2 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Macrocephaly 1 5.00 Very Low Very Low Very Low
Cleidocranial Dysplasia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gene expression analysis shows a 2.7 fold increase in the expression of dopamine 3 receptor in Nf1+/- brains at post natal day 15.
Positive_regulation (increase) of Gene_expression (expression) of dopamine 3 receptor in brains associated with dopamine
1) Confidence 0.54 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1434756 Disease Relevance 0.09 Pain Relevance 0.23
The time-course of altered D3 receptor expression, in line with the delayed clinical efficiency of antidepressant treatment, and the fact that various antidepressant drugs and ECT treatments eventually produced the same effects, suggest that increased expression of the D3 receptor in the shell of nucleus accumbens is a common neurobiological mechanism of antidepressant treatments, resulting in enhanced responsiveness to the mesolimbic dopaminergic system.
Positive_regulation (increased) of Gene_expression (expression) of D3 receptor in nucleus accumbens associated with nucleus accumbens and antidepressant
2) Confidence 0.31 Published 2000 Journal Mol. Psychiatry Section Abstract Doc Link 10889548 Disease Relevance 0.06 Pain Relevance 0.83
Selective increase of dopamine D3 receptor gene expression as a common effect of chronic antidepressant treatments.
Positive_regulation (increase) of Gene_expression (expression) of D3 receptor associated with antidepressant, dopamine and endep
3) Confidence 0.27 Published 2000 Journal Mol. Psychiatry Section Title Doc Link 10889548 Disease Relevance 0.08 Pain Relevance 0.73
In contrast, treatments for 21 days (with all drugs except fluoxetine) significantly increased D3 receptor mRNA expression in the shell of nucleus accumbens; D3 receptor binding was also significantly increased by amitriptyline or fluoxetine after a 42-day treatment.
Positive_regulation (increased) of Gene_expression (expression) of D3 receptor in nucleus accumbens associated with nucleus accumbens, endep and fluoxetine
4) Confidence 0.22 Published 2000 Journal Mol. Psychiatry Section Abstract Doc Link 10889548 Disease Relevance 0.09 Pain Relevance 0.85

General Comments

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