INT89329

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Context Info
Confidence 0.61
First Reported 2000
Last Reported 2004
Negated 3
Speculated 1
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 0.72
Pain Relevance 3.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Drd3) plasma membrane (Drd3) signal transducer activity (Drd3)
Anatomy Link Frequency
nucleus accumbens 4
striatum 2
forebrain 2
midbrain 2
Drd3 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 20 100.00 Very High Very High Very High
antidepressant 18 100.00 Very High Very High Very High
Endep 12 100.00 Very High Very High Very High
fluoxetine 9 100.00 Very High Very High Very High
Desipramine 3 100.00 Very High Very High Very High
Nucleus accumbens 12 99.16 Very High Very High Very High
midbrain 2 98.60 Very High Very High Very High
dopamine receptor 2 96.60 Very High Very High Very High
Morphine 2 86.16 High High
Central nervous system 2 80.52 Quite High
Disease Link Frequency Relevance Heat
Shock 3 100.00 Very High Very High Very High
Dyskinesias 5 95.12 Very High Very High Very High
Toxicity 2 76.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Under these conditions, no change in dopamine D3 receptor mRNA expression in the limbic forebrain and lower midbrain was observed by prenatal and neonatal exposure to BPA.
Neg (no) Regulation (change) of Gene_expression (expression) of dopamine D3 receptor mRNA in midbrain associated with dopamine and midbrain
1) Confidence 0.61 Published 2004 Journal Addict Biol Section Abstract Doc Link 15203435 Disease Relevance 0.08 Pain Relevance 0.44
The present data provide further evidence that prenatal and neonatal exposure to BPA leads to the reduction of functional dopamine D3 receptors without affecting the new synthesis of dopamine D3 receptors in the mouse limbic forebrain.
Neg (without) Regulation (affecting) of Gene_expression (synthesis) of dopamine D3 in forebrain associated with dopamine
2) Confidence 0.45 Published 2004 Journal Addict Biol Section Abstract Doc Link 15203435 Disease Relevance 0.06 Pain Relevance 0.42
The time-course of altered D3 receptor expression, in line with the delayed clinical efficiency of antidepressant treatment, and the fact that various antidepressant drugs and ECT treatments eventually produced the same effects, suggest that increased expression of the D3 receptor in the shell of nucleus accumbens is a common neurobiological mechanism of antidepressant treatments, resulting in enhanced responsiveness to the mesolimbic dopaminergic system.
Regulation (altered) of Gene_expression (expression) of D3 receptor in nucleus accumbens associated with nucleus accumbens and antidepressant
3) Confidence 0.27 Published 2000 Journal Mol. Psychiatry Section Abstract Doc Link 10889548 Disease Relevance 0.07 Pain Relevance 0.89
Short-term drug treatments had variable effects on D3 receptor mRNA expression.
Regulation (effects) of Gene_expression (expression) of D3 receptor
4) Confidence 0.20 Published 2000 Journal Mol. Psychiatry Section Abstract Doc Link 10889548 Disease Relevance 0.09 Pain Relevance 0.79
Here we examined the effects of chronic administration of antidepressants of several classes (amitriptyline, desipramine, imipramine, fluoxetine and tranylcypromine) and repeated electroconvulsive shock treatments (ECT) on dopamine D3 receptor expression in the shell of the nucleus accumbens, a major projection area of the mesolimbic dopaminergic system.
Spec (examined) Regulation (effects) of Gene_expression (expression) of D3 receptor in nucleus accumbens associated with nucleus accumbens, dopamine, desipramine, antidepressant, shock, endep and fluoxetine
5) Confidence 0.18 Published 2000 Journal Mol. Psychiatry Section Abstract Doc Link 10889548 Disease Relevance 0.10 Pain Relevance 0.75
Chronic high dose L-dopa treatment does not alter the levels of dopamine D-1, D-2 or D-3 receptor in the striatum of normal monkeys: an autoradiographic study.
Neg (not) Regulation (alter) of Gene_expression (levels) of D-3 receptor in striatum associated with dopamine
6) Confidence 0.02 Published 2001 Journal J Neural Transm Section Title Doc Link 11716146 Disease Relevance 0.32 Pain Relevance 0.28

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