INT89330

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Context Info
Confidence 0.31
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.16
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Drd3) plasma membrane (Drd3) signal transducer activity (Drd3)
Anatomy Link Frequency
shell 2
nucleus accumbens 2
Drd3 (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 8 99.96 Very High Very High Very High
Endep 8 99.84 Very High Very High Very High
fluoxetine 6 99.16 Very High Very High Very High
Dopamine 4 85.44 High High
Desipramine 2 81.00 Quite High
antidepressant 12 80.00 Quite High
Disease Link Frequency Relevance Heat
Shock 2 84.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ECT for 10 days increased D3 receptor mRNA and binding in the shell of nucleus accumbens.
Positive_regulation (increased) of D3 receptor Binding (binding) of in shell associated with nucleus accumbens
1) Confidence 0.31 Published 2000 Journal Mol. Psychiatry Section Abstract Doc Link 10889548 Disease Relevance 0.08 Pain Relevance 0.90
In contrast, treatments for 21 days (with all drugs except fluoxetine) significantly increased D3 receptor mRNA expression in the shell of nucleus accumbens; D3 receptor binding was also significantly increased by amitriptyline or fluoxetine after a 42-day treatment.
Positive_regulation (increased) of D3 receptor Binding (binding) of in nucleus accumbens associated with nucleus accumbens, endep and fluoxetine
2) Confidence 0.18 Published 2000 Journal Mol. Psychiatry Section Abstract Doc Link 10889548 Disease Relevance 0.08 Pain Relevance 0.91

General Comments

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