INT89334

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Context Info
Confidence 0.47
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.05
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (SP1) nucleus (SP1) intracellular (SP1)
DNA binding (SP1) transcription factor binding (SP1) cytoplasm (SP1)
SP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Cholecystokinin 7 96.96 Very High Very High Very High
withdrawal 1 78.68 Quite High
cytokine 12 73.52 Quite High
analgesia 1 67.52 Quite High
Neuropeptide 1 58.96 Quite High
Inflammation 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alcohol Addiction 3 92.84 High High
Panic Disorder 3 80.08 Quite High
Substance Withdrawal Syndrome 1 79.04 Quite High
Schizophrenia 1 71.12 Quite High
Mental Disorders 1 69.60 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 141 68.40 Quite High
Anxiety Disorder 1 67.08 Quite High
Infection 11 50.72 Quite High
Disease 9 22.12 Low Low
Cancer 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We demonstrate that substitution of the C-36 residue causes a slight reduction of Sp1 and Sp3 binding, but this has no effect on transcription in vivo.
Negative_regulation (reduction) of Sp1 Binding (binding) of
1) Confidence 0.47 Published 2000 Journal Mol. Psychiatry Section Abstract Doc Link 10889557 Disease Relevance 0.77 Pain Relevance 0.39
The reduction of LTR expression is possibly explained by the binding of methyl-CpG-binding protein 1 complex and methyl-CpG-binding protein 2 to methylated Sp1 transcription factor binding sites, thereby inhibiting the binding of Sp1 transcription factors [282,283].
Negative_regulation (inhibiting) of Sp1 Binding (binding) of
2) Confidence 0.15 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.29 Pain Relevance 0.11

General Comments

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