INT89337

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Context Info
Confidence 0.58
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.14
Pain Relevance 3.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCK) extracellular space (CCK) extracellular region (CCK)
Anatomy Link Frequency
plasma 2
CCK (Homo sapiens)
Pain Link Frequency Relevance Heat
Cholecystokinin 76 100.00 Very High Very High Very High
Chronic pancreatitis 55 98.92 Very High Very High Very High
withdrawal 1 96.94 Very High Very High Very High
Pain 21 90.08 High High
analgesia 2 82.72 Quite High
nud 2 81.28 Quite High
Inflammation 7 80.36 Quite High
Neuropeptide 2 74.16 Quite High
tolerance 1 73.16 Quite High
spastic colon 3 68.16 Quite High
Disease Link Frequency Relevance Heat
Critical Illness 53 100.00 Very High Very High Very High
Pancreatitis 55 98.92 Very High Very High Very High
Panic Disorder 3 97.64 Very High Very High Very High
Substance Withdrawal Syndrome 1 97.12 Very High Very High Very High
Alcohol Addiction 3 96.64 Very High Very High Very High
Pain 20 90.08 High High
Schizophrenia 1 86.32 High High
Mental Disorders 1 84.80 Quite High
Anxiety Disorder 1 82.28 Quite High
Dyspepsia 2 81.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, a number of studies have indicated that a C-36 to T transition in the CCK gene promoter Sp1 element4 (Figure 1) is associated with alcoholism and withdrawal symptoms as well as panic disorder.5-7 Moreover, it has been proposed that the polymorphism plays a direct role in the pathogenesis of the disorders by decreasing the expression and synthesis of CCK peptides.
Negative_regulation (decreasing) of Gene_expression (expression) of CCK associated with panic disorder, alcohol addiction, withdrawal and cholecystokinin
1) Confidence 0.58 Published 2000 Journal Mol. Psychiatry Section Abstract Doc Link 10889557 Disease Relevance 0.77 Pain Relevance 0.46
Relationship between plasma PYY and CCK concentrations in critical illness
Negative_regulation (illness) of Gene_expression (concentrations) of CCK in plasma associated with critical illness and cholecystokinin
2) Confidence 0.41 Published 2006 Journal Crit Care Section Body Doc Link PMC1794491 Disease Relevance 0.29 Pain Relevance 0.39
During rapid phasic distension but not during slow ramp distension, CCK-OP at 40 ng kg-1 h-1 produced a significant decrease in sensory thresholds compared with the basal period.
Negative_regulation (decrease) of Gene_expression (produced) of CCK associated with cholecystokinin
3) Confidence 0.37 Published 2002 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 12464091 Disease Relevance 0.21 Pain Relevance 0.64
In CP patients with PEI, lack of serine proteases leads to uninhibited production of CCK, a potent stimulator of pancreatic enzymes.
Negative_regulation (uninhibited) of Gene_expression (production) of CCK associated with cholecystokinin and chronic pancreatitis
4) Confidence 0.13 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710383 Disease Relevance 1.74 Pain Relevance 1.72

General Comments

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