INT89366

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Context Info
Confidence 0.18
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.18
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Klk1c8)
Klk1c8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spastic colon 24 99.52 Very High Very High Very High
Arthritis 6 98.96 Very High Very High Very High
Hyperalgesia 2 97.36 Very High Very High Very High
allodynia 2 96.72 Very High Very High Very High
nud 4 93.24 High High
agonist 1 90.08 High High
Inflammation 10 87.12 High High
cINOD 3 75.00 Quite High
Inflammatory response 1 69.76 Quite High
antagonist 5 65.32 Quite High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

23 99.52 Very High Very High Very High
Diarrhoea 3 99.16 Very High Very High Very High
Experimental Arthritis 5 98.96 Very High Very High Very High
Hyperalgesia 2 97.36 Very High Very High Very High
Neuropathic Pain 2 96.72 Very High Very High Very High
Disorder Of Lipid Metabolism 2 94.32 High High
Dyspepsia 4 93.24 High High
INFLAMMATION 11 87.12 High High
Stress 46 73.36 Quite High
Arthritis 1 51.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of adjuvant arthritis (AA) on the pattern of rat serum proteins includes the upregulation of haptoglobin, orosomucoid, alpha2-macroglobulin, serine protease inhibitor-3, thiostatin, alpha1-antitrypsin, C-reactive protein, and the downregulation of kallikrein-binding protein, alpha1-inhibitor III, apolipoprotein A-I, alpha2-HS-glycoprotein, albumin, apolipoprotein A-IV, transthyretin and transferrin.
Positive_regulation (upregulation) of serine protease associated with experimental arthritis, disorder of lipid metabolism and arthritis
1) Confidence 0.18 Published 2000 Journal Electrophoresis Section Abstract Doc Link 10892728 Disease Relevance 0.79 Pain Relevance 0.34
Actually, elevated colonic luminal serine protease activity is seen in diarrhea-predominant IBS patients (29, 30).
Positive_regulation (elevated) of colonic luminal serine protease associated with diarrhoea and spastic colon
2) Confidence 0.06 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923781 Disease Relevance 1.11 Pain Relevance 0.77

General Comments

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