INT89368

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Context Info
Confidence 0.34
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.62
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tf) mitochondrion (Tf) extracellular space (Tf)
extracellular region (Tf) cytoplasmic membrane-bounded vesicle (Tf)
Anatomy Link Frequency
plasma 1
lymphocytes 1
PSCs 1
brains 1
Tf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 6 98.96 Very High Very High Very High
cytokine 14 89.56 High High
Inflammatory response 1 89.36 High High
Dopamine 24 81.08 Quite High
corticosteroid 1 80.32 Quite High
Inflammation 6 76.72 Quite High
cINOD 3 75.00 Quite High
Central nervous system 9 74.80 Quite High
agonist 7 72.60 Quite High
tolerance 4 37.36 Quite Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 2 100.00 Very High Very High Very High
Coagulation Disorder 1 100.00 Very High Very High Very High
Cancer 11 99.60 Very High Very High Very High
Experimental Arthritis 5 98.96 Very High Very High Very High
Congenital Anomalies 3 97.40 Very High Very High Very High
Restless Legs Syndrome 96 97.12 Very High Very High Very High
INFLAMMATION 9 89.36 High High
Necrosis 1 88.20 High High
Alzheimer's Dementia 2 86.80 High High
Metabolic Syndrome 3 77.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRF death induction was restricted to activated PSCs because it did not cause apoptosis either in quiescent PSCs or in acinar cells.
Positive_regulation (induction) of TRF in PSCs
1) Confidence 0.34 Published 2007 Journal Gastroenterology Section Body Doc Link 17570223 Disease Relevance 0.16 Pain Relevance 0
The effect of adjuvant arthritis (AA) on the pattern of rat serum proteins includes the upregulation of haptoglobin, orosomucoid, alpha2-macroglobulin, serine protease inhibitor-3, thiostatin, alpha1-antitrypsin, C-reactive protein, and the downregulation of kallikrein-binding protein, alpha1-inhibitor III, apolipoprotein A-I, alpha2-HS-glycoprotein, albumin, apolipoprotein A-IV, transthyretin and transferrin.
Positive_regulation (upregulation) of transferrin associated with experimental arthritis, disorder of lipid metabolism and arthritis
2) Confidence 0.25 Published 2000 Journal Electrophoresis Section Abstract Doc Link 10892728 Disease Relevance 0.98 Pain Relevance 0.51
Tfn endocytosed into HT29 cells and accumulated in the early/late and recycling endosomes in the cytoplasm (Figure 5a), but the level of endocytic Tfn-fluorescence decreased in a dose-dependent manner in geoditin A-treated cells (Figures 5b–d), and a decrease of >30% labeled transferrin in these cells was measured by flow cytometric analysis (Figure 5e).
Positive_regulation (accumulated) of Tfn
3) Confidence 0.10 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2817924 Disease Relevance 0.37 Pain Relevance 0
These signaling cascades result in increased plasma levels of a number of positive acute-phase proteins (APPs), including clotting proteins, transport proteins, antiproteases, and complement factors, with a parallel decrease in negative APPs, such as albumin or transferrin (Ramadori and Christ 1999).
Positive_regulation (increased) of transferrin in plasma associated with coagulation disorder
4) Confidence 0.08 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0.62 Pain Relevance 0.12
Neuropathological examination of brains from RLS patients revealed no histopathological abnormalities, but did show that iron, ferritin, and transferrin receptor staining all were markedly decreased in substania nigra cells, while transferrin staining was increased and tyrosine hydroxylase was present at normal levels, suggesting that RLS may be a functional disorder of iron processing in these neuromelanin cells that impairs the dopaminergic system (Connor et al., 2003).


Positive_regulation (increased) of transferrin in brains associated with congenital anomalies and restless legs syndrome
5) Confidence 0.04 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC2995617 Disease Relevance 0.97 Pain Relevance 0.08
Inorganic Hg, but not MeHg, can induce the metal-binding protein metallothionein.
Positive_regulation (induce) of metal-binding protein
6) Confidence 0.02 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2831924 Disease Relevance 0 Pain Relevance 0
An iron deficient diet eliminated this circadian variation, and also decreased central iron stores, particularly during the inactive light phase.27 Earley and coworkers found that lymphocytes of patients with RLS exhibited increased expression of transferrin receptors as well as ferroportin.28 Since ferroportin is implicated in cellular iron excretion and elevated transferrin is a sign of intracellular depletion, these findings suggest the presence of a disrupted turnover of iron in RLS.
Positive_regulation (elevated) of transferrin in lymphocytes associated with restless legs syndrome
7) Confidence 0.01 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857615 Disease Relevance 0.51 Pain Relevance 0.13

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