INT89379

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Context Info
Confidence 0.50
First Reported 2000
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.37
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNF, IL6) extracellular region (TNF, IL6) signal transduction (TNF)
aging (IL6) plasma membrane (TNF) intracellular (TNF)
Anatomy Link Frequency
joint 2
smooth muscle cells 2
TNF (Homo sapiens)
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 68 100.00 Very High Very High Very High
chemokine 50 99.80 Very High Very High Very High
Inflammation 79 96.36 Very High Very High Very High
Inflammatory response 9 90.08 High High
rheumatoid arthritis 127 90.04 High High
Inflammatory mediators 2 89.96 High High
antagonist 3 85.60 High High
metalloproteinase 25 74.40 Quite High
Infliximab 5 58.24 Quite High
Arthritis 12 56.16 Quite High
Disease Link Frequency Relevance Heat
Necrosis 11 97.12 Very High Very High Very High
Cancer 13 96.76 Very High Very High Very High
INFLAMMATION 86 96.36 Very High Very High Very High
Atherosclerosis 6 94.08 High High
Rheumatoid Arthritis 127 90.04 High High
Stress 2 85.84 High High
Disease 32 81.44 Quite High
Arthritis 20 81.08 Quite High
Insulin Resistance 4 77.64 Quite High
Adhesions 32 72.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together, TNF and IL-1 stimulate the production of IL-6 by smooth muscle cells (Ng et al 1994).
TNF Positive_regulation (stimulate) of Gene_expression (production) of IL-6 in smooth muscle cells
1) Confidence 0.50 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993951 Disease Relevance 1.53 Pain Relevance 0.44
TNF-alpha, but not IL-6 or IL-1beta production, increased 2.4-fold 24 h after ECC (P<0.05).
TNF-alpha Positive_regulation (increased) of Gene_expression (production) of IL-6
2) Confidence 0.20 Published 2000 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 10893341 Disease Relevance 0.55 Pain Relevance 0.04
The production of PGE2, MMP-1, IL-8, IL-6, RANTES and IP-10 induced by hTWEAK (but not the production induced by TNF and IL-1?)
TNF Positive_regulation (induced) of Gene_expression (production) of IL-6
3) Confidence 0.09 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.39 Pain Relevance 0.04
In addition, IL-1 and TNF induce the production of IL-6 and chemokines (e.g.
TNF Positive_regulation (induce) of Gene_expression (production) of IL-6 associated with chemokine
4) Confidence 0.09 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 1.28 Pain Relevance 0.60
IL-1 and TNF stimulate the production of degradative proteases and cytokines such as IL-1, IL-6, IL-8 and MCP-1 by joint tissue cells, contributing to joint destruction.
TNF Positive_regulation (stimulate) of Gene_expression (production) of IL-6 in joint associated with cytokine
5) Confidence 0.03 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 0.61 Pain Relevance 0.57

General Comments

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