INT89381

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Context Info
Confidence 0.43
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.06
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (INS, AKT1) carbohydrate metabolic process (INS, AKT1) cell differentiation (AKT1)
nucleoplasm (AKT1) transport (AKT1) protein modification process (AKT1)
Anatomy Link Frequency
fibroblast 2
muscle 1
INS (Homo sapiens)
AKT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 54 83.68 Quite High
Inflammatory stimuli 5 82.96 Quite High
Inflammation 56 75.20 Quite High
COX-2 inhibitor 1 39.64 Quite Low
Inflammatory mediators 2 25.08 Quite Low
Pain 1 25.00 Low Low
COX2 1 23.20 Low Low
Kinase C 11 5.00 Very Low Very Low Very Low
bradykinin 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 91 95.40 Very High Very High Very High
Hyperglycemia 42 91.56 High High
Necrosis 8 91.24 High High
Cancer 61 90.88 High High
Obesity 115 86.88 High High
Insulin Resistance 41 85.04 High High
Disease Progression 2 84.36 Quite High
Disease 41 83.08 Quite High
INFLAMMATION 63 82.96 Quite High
Breast Cancer 60 79.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Insulin-stimulated phosphatidylinositol (PI) 3-kinase, Akt (protein kinase B) serine phosphorylation, and Akt activity were reduced 34, 65, and 20%, respectively, after ECC (P < 0.05).
Insulin Positive_regulation (stimulated) of Akt
1) Confidence 0.43 Published 2000 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 10893341 Disease Relevance 0.59 Pain Relevance 0.04
There is no mechanistic information from work in human muscle showing how insulin might reduce MPB, although there is evidence that insulin-stimulated PKB activity induces phosphorylation of the FOXO family of transcription factors (18, 32), which inhibits their transcriptional activity by localizing them to the cytoplasm.
insulin Positive_regulation (stimulated) of PKB in muscle
2) Confidence 0.16 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0.08 Pain Relevance 0
The PI3K/Akt/mammalian target of rapamycin (mTOR) pathway is activated by a number of growth factors, including insulin, insulin-like growth factor I, basic fibroblast growth factor, EGF and VEGF.
insulin Positive_regulation (activated) of Akt in fibroblast
3) Confidence 0.04 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.43 Pain Relevance 0
The PI3K/Akt/mammalian target of rapamycin (mTOR) pathway is activated by a number of growth factors, including insulin, insulin-like growth factor I, basic fibroblast growth factor, EGF and VEGF.
insulin Positive_regulation (activated) of Akt in fibroblast
4) Confidence 0.04 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.43 Pain Relevance 0
All these metabolic alterations are associated with an increase in caspase-3 activity and an impaired ability of insulin at a physiological concentration to activate Akt.
insulin Positive_regulation (activate) of Akt
5) Confidence 0.03 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 0.77 Pain Relevance 0
One important finding of our study is that Tpl2 was not required for the activation of ERK or PKB pathways by insulin.
insulin Positive_regulation (activation) of PKB
6) Confidence 0.01 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.75 Pain Relevance 0.29

General Comments

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